IndraLab

Statements

USP24 inhibits TBK1. 2 / 2

| 2

reach

"Knockdown of USP24 upregulated TBK1 K63-linked polyubiquitination, promoted the phosphorylation and nuclear translocation of IRF3, and in turn improved IFN-I production during EV71 infection."

36334706

➶

reach

"Mechanistically, USP24 can target TBK1 and reduce TBK1 K63-linked polyubiquitination modifications dependently on the Lys154 residue of TBK1, resulting in decreased IRF3 activation and nuclear translocation."

36334706

INDRA sources:

Colored badges next to statement headings correspond to evidence counts from knowledge sources, as shown below. Badges to the left of the | separator correspond to curated knowledge base sources, and badges to the right of it correspond to machine reading systems.

IndraLab

Statements

USP24 inhibits TBK1. 2 / 2

INDRA sources:

Databases

Reading