IndraLab

Statements

BRCC3 affects NLRP3
1 | 49 2
BRCC3 deubiquitinates NLRP3.
| 35
BRCC3 deubiquitinates NLRP3. 10 / 33
| 33
reach
"Lys-63-specific deubiquitinase BRCC36 (BRCC3), a JAMM domain containing Zn 2+ metalloprotease, promotes NLRP3 deubiquitination during priming and regulates NLRP3 activation [26]."
27669650
reach
"Viral RNA (vRNA) molecule-induced NLRP3 inflammasome activation also comes about by post-translational priming, but involving the RIP1/caspase 8/RIP3 signaling pathway (29, 45), which may ultimately result in the deubiquitination of NLRP3 protein by BRCC3 (46, 47)."
29163496
reach
"The K-63-specific deubiquitinating enzyme BRCC3 mediates the deubiquitylation of NLRP3, which has recently been shown to occur in response to pattern recognition receptor stimulation [XREF_BIBR]."
29120406
reach
"BRCC3 inhibition promotes NLRP3 ubiquitination and blocks inflammasome assembly but does not target NLRP3 for degradation."
30288079
reach
"By screening a deubiquitinating enzyme (DUB) library, they recognized that BRCC3 (BRCA1, BRCA2, and containing complex subunit 3) deubiquitinates the LRR domain of NLRP3, which then proceeds NLRP3 activation 59."
30755589
reach
"A posttranscriptional modification, such as NLRP3 deubiquitination mediated by BRCA1/BRCA2-containing complex subunit 3 (BRCC3), is required for NLRP3 activation (signal 2) [67, 68]."
31687078
reach
"For example, breast cancer 1 (BRCA1)/breast cancer 2 (BRCA2)-containing complex subunit 3 (BRCC3) deubiquitinates NLRP3, and pharmaceutical inhibition of DUBs restricts inflammasome activation [79,112,113], whereas E3 ubiquitin ligases LUBAC and TRIM33 promote inflammasome assembly [114,115]."
27783058
reach
"Py et al. found that BRCC3 promotes NLRP3 inflammasome activation by deubiquitinating the LRR domain of NLRP3 50."
25762778
reach
"Recently, BRCC3 in the cytosol has been reported to promote the inflammasome activation by deubiquitinating NLRP3 in LPS primed macrophages [XREF_BIBR]."
25337721
reach
"A subsequent study identified that the deubiquitinating enzyme, BRCC3, mediates the deubiquitination of NLRP3 [27]."
32545355
Modified BRCC3 leads to the deubiquitination of NLRP3. 1 / 1
| 1
reach
"In addition, consistent with its role as a deubiquitination enzyme for NLRP3, BRCC3 expression significantly reduced the extent of NLRP3 covalent ubiquitination in 293T cells."
23246432
BRCC3 deubiquitinates NLRP3 at position 153. 1 / 1
| 1
reach
"Besides phosphorylation, the deubiquitinating enzyme BRCA1/BRCA2-containing complex subunit 3 (BRCC3) promotes an inflammasome activation by deubiquitinating NLRP3 at its LRR domain 153 ."
32550001
BRCC3 binds NLRP3.
| 4 2
NLRP3 binds BRCC3. 3 / 3
| 3
reach
"This work suggested that BRCC3 directly interacted with NLRP3, and its presence was required for appropriate NLRP3 inflammasome formation."
31679183
reach
"BRCC3 can directly bind to NLRP3 and favors NLRP3 inflammasome activation through its deubiquitination."
| PMC
reach
"Co-IP experiments confirmed the interaction between BRCC3 and NLRP3."
34874278
BRCC3 binds NLRP3. 2 / 2
| 2
isi
"VDR can physically bind NLRP3 and block the association of NLRP3 with BRCC3."
31866999
isi
"This was mediated by enhanced deubiquitination of NLRP3 via binding with deubiquitinases BRCC3 and JOSD2, which are highly expressed in myeloid cells."
32941940
Ubiquitinated NLRP3 binds BRCC3. 1 / 1
| 1
reach
"Consistent with a regulatory role of BRCC3 with NLRP3 inflammasome, we found that endogenous BRCC3 coimmunoprecipitated with Flag-NLRP3 from NG5 cell lysates and with endogenous NLRP3 from LPS primed [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23246432
BRCC3 activates NLRP3.
| 5
BRCC3 activates NLRP3. 5 / 5
| 5
reach
"Regulation of oxidized LDL induced inflammatory process through NLRP3 inflammasome activation by the deubiquitinating enzyme BRCC36."
31485755
reach
"The authors further suggested that the deubiquitylation of NLRP3 was critical for the inflammasome activation based on the facts that inhibiting BRCC3 could abolish NLRP3 inflammasome activation under a diverse range of classic " activation signals, " including K + efflux, ROS overproduction, and lysosomal destabilization."
25698849
reach
"Moreover, USP7, USP47, and BRCC3 and ABRO can activate the NLRP3 inflammasome."
32850399
reach
"The BRCC3 regulated by Cdk5 promotes the activation of neuronal NLRP3 inflammasome in Parkinson 's disease models."
31787240
reach
"Deubiquitination of NLRP3 by the BRCA1 / BRCA2 containing complex subunit 3 (BRCC3) promoted NLRP3 inflammasome activity by preventing its degradation 39."
32424362
BRCC3 ubiquitinates NLRP3.
1 | 2
BRCC3 ubiquitinates NLRP3. 3 / 3
1 | 2
bel
" NLRP3 deubiquitylation is mediated by the K63-specific deubiquitinase BRCC3 (REF. 63)."
23702978
reach
"Previous reports have described TRIM31, FBXL2, and MARCH7 to promote ubiquitination and degradation of NLRP3 XREF_BIBR - XREF_BIBR with de-ubiquitination by the BRCC3 complex facilitating activation of NLRP3 XREF_BIBR - XREF_BIBR."
29674674
reach
"SYVN1-mediated BRCC3 down-regulation promoted NLRP3 ubiquitination and reduced pro-inflammatory cytokine secretion."
34874278
BRCC3 inhibits NLRP3.
| 3
BRCC3 inhibits NLRP3. 3 / 3
| 3
reach
"Functionally, we show that lentivirus mediated overexpression of WWP2 in murine macrophages inhibits NLRP3 inflammasome activation by decreasing BRCC3 protein level."
33107021
reach
"Knock-down of BRCC3 with shRNA lentivirus decreased NLRP3 neuronal inflammasome."
31787240
reach
"BRCC3 knockdown leads to an increase in NLRP3 ubiquitination, and the DUB activity of BRCC3 is required for caspase-1 activation and IL-1beta processing, but not for LPS induced transcription of pro-IL-1beta or of NLRP3 itself XREF_BIBR."
24375678
BRCC3 affects BRCA1
8 1 | 1 29 1
BRCC3 binds BRCA1.
8 1 | 1 21 1
BRCA1 binds BRCC3. 10 / 22
8 1 | 1 9
reach
"Mutations that abolish the interaction between BRCA1 and BRCC36 reduce the association of BRCA2 and RAD51 to the complex, whereas mutations that abolish BARD1 interaction with BRCA1 had no effect on the association of the above proteins [XREF_BIBR]."
24832651
biogrid
No evidence text available
25184681
biogrid
No evidence text available
14636569
biogrid
No evidence text available
25252691
hprd
No evidence text available
14636569
reach
"BRCC3 directly interacts with BRCA1 at the region encompassing amino acids 502 to 1054 [XREF_BIBR], which falls within the BRCA1 DNA binding domain (amino acids 452-1079)."
26024915
reach
"Together these data indicate a direct interaction of BRCA1 and BRCC36 which is lost following cancer causing truncations of BRCA1.To directly address the role of BRE and BRCC36 in BRCC 's ubiquitin E3[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
14636569
reach
"BRCC36, one of the proteins in BRCC, directly interacts with BRCA1, and regulates the ubiquitin E3 ligase activity of BRCC."
16707425
reach
"The deubiquitinase BRCA1-BRCA2-containing complex subunit 3 (BRCC3)-mediated nucleotide-binding domain and leucine-rich repeat receptor containing a pyrin domain 3 (NLRP3) inflammasome activation participates in this progress."
34874278
trips
"Abraxas mainly localizes in the nucleus, mediating the interaction of BRCC36 with BRCA1."
21282113
BRCA1 binds BRCC3, UIMC1, and Abraxas. 6 / 6
| 6
reach
"BRCA1 encodes a protein forming the Rap80, Abraxas, Brca1, and Brcc36 complex in response to DNA damage XREF_BIBR."
29158785
reach
"UBC13 and RNF8 ubiquitin ligases control focus formation of the Rap80, Abraxas, Brca1, and Brcc36 complex in response to DNA damage."
24732096
reach
"It was proposed that the role of the BRCA1, Abraxas, RAP80, and BRCC36 complex is to limit DSB resection."
21666281
reach
"This activity and histone modification is required for the recruitment of other DDR proteins, specifically 53BP1 and the Rap80, Abraxas, Brca1, and Brcc36 complex to DSBs [167,168]."
19473885
reach
"Ubc13 and Rnf8 ubiquitin ligases control foci formation of the Rap80, Abraxas, Brca1, and Brcc36 complex in response to DNA damage."
18077395
reach
"Recruitment of the 53BP1 and Rif1 complex to DSBs promotes NHEJ repair and prevents the HR promoting BRCA1 and CtIP complex from binding to DSB sites (Chapman et al., 2013; Di Virgilio et al., 2013; F[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28943310
BRCA1 binds BRCC3, BARD1, and Abraxas. 3 / 3
| 3
reach
"Interactions of Abraxas, BACH1 and CtIP with the BRCT domain of BRCA1 are mutually exclusive, suggesting that the three proteins compete for the same binding site to form distinct BRCA1 containing complexes, of which only the Abraxas, BRCC36, BRCA1, and BARD1 complex is recruited to sites of DNA damage by RAP80 [XREF_BIBR]."
19473884
reach
"Receptor associated protein 80 (RAP80) plays a key role in recruiting the Abraxas, BRCC36, BRCA1, and BARD1 complex to DNA damage foci for DNA repair by possessing an Abraxas interacting region."
20357899
reach
"RAP80 has a key role in the recruitment of the Abraxas, BRCC36, BRCA1, and BARD1 complex to DNA-damage foci for DNA repair through specific recognition of Lys 63 linked polyubiquitinated proteins by its tandem ubiquitin interacting motifs (UIMs)."
19536136
BRCA1 binds BABAM2, BRCC3, and BARD1. 2 / 2
| 2
reach
"Furthermore, it has been demonstrated that in M-phase cells Rap80 exists in complex with the BRCA1, BARD1, BRCC36, and BRCC45 complex which is very abundant and its association is dependent on BRCC36 [XREF_BIBR]."
24832651
reach
"Fifth, through reconstitution of the BRCA1, BARD1, BRCC36, and BRE complex it demonstrates a role for BRCC36 and BRE in modulation of BRCA1 and BARD1 E3 ubiquitin ligase activity."
14636569
reach
"As discussed in Section 5.7, SUMOylation of BRCA1 is a prerequisite for BRCA1 's efficient in vitro and in vivo ubiquitylation activity [602,603], and autoubiquitylation [1038,1039] may promote this a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22743550
BRCA1 binds BRCA1, BRCC3, UIMC1, and Abraxas. 1 / 1
| 1
sparser
"After polyubiquitination of the chromatin, Brca1, a tumor suppressor protein that also possesses ubiquitin ligase activity, especially when it is complexed with Bard1, is recruited to the lesion together with Rap80, Abraxas, Brca1 and Brcc36, which form the BRCA1-A complex [ xref ]."
21037856
BRCC3 inhibits BRCA1.
| 2
BRCC3 inhibits BRCA1. 2 / 5
| 2
reach
"The study has demonstrated that BRCC3 depletion prevents the formation of BRCA1 nuclear foci, and subsequently impairs the DNA repair pathway in response to DNA damage by ionizing radiation in breast cancer cells, suggesting that BRCC3 is referred as a potential therapeutic target for breast cancer [XREF_BIBR]."
25337721
reach
"Immunofluorescent staining of BRCA1 and gamma-H2AX indicates that BRCC36 depletion prevents the formation of BRCA1 nuclear foci in response to DNA damage in breast cancer cells."
16707425
BRCC3 activates BRCA1.
| 4
BRCC3 activates BRCA1. 4 / 5
| 4
reach
"The so called BRCA1-A complex comprises RAP80, Abraxas and CCDC98, the deubiquitinase BRCC36, BRCC45 and MERIT40, which are thought to target BRCA1 to IR induced foci through the interaction of RAP80 with polyubiquitin chains such as is thought to occur at histone gamma-H2AX [XREF_BIBR, XREF_BIBR] (see XREF_FIG)."
24278741
reach
"These results indicate that the two new subunits, BRCC36 and BRE, potentiate the E3 ligase activity of BRCA1 and BARD1."
14636569
reach
"But beside the canonical role of deubiquitinating enzymes in antagonizing ubiquitin ligase activity, BRCC36 also enhances BRCA1 and BARD1 E3 ubiquitin ligase activity."
20817926
reach
"Notably, BRCC36 depletion has been shown to impair activation of BRCA1 and to sensitise breast cancer cells to IR-induced apoptosis [146]."
23712866
BRCC3 ubiquitinates BRCA1.
| 1
BRCC3 leads to the ubiquitination of BRCA1. 1 / 1
| 1
reach
"Further, BRCC36 and BRCC45 enhance the E3 ubiquitin ligase activity of the multiprotein complex BRCA1, BARD1, and BRCA2 and ubiquitination of p53 in vitro."
16854521
BRCC3 dephosphorylates BRCA1.
| 1
BRCC3 leads to the dephosphorylation of BRCA1. 1 / 1
| 1
reach
"Depletion of BRCC36 abrogated BRCA1 phosphorylation and nuclear foci formation in breast cancer cells exposed to ionizing radiation (IR), thereby sensitizing these tumor cells to IR induced apoptosis [XREF_BIBR]."
27844253
ABRAXAS2 affects BRCC3
10 | 27
ABRAXAS2 binds BRCC3.
10 | 21
BRCC3 binds ABRAXAS2. 10 / 34
10 | 21
reach
"These observations support the notion that the crystal structure of the BRCC36 and KIAA0157 heterodimer is reflective of both BRCC36-KIAA0157 and the BRCC36-Abraxas interactions in cells, and that perturbation of heterodimerization has far reaching consequences on the assembly of other subunits."
26344097
reach
"Structure of the BRCC36 and KIAA0157 heterodimer is functionally relevant in cells."
26344097
reach
"Furthermore, Abro1 binding to BRCC36 promotes the catalytic activity of the enzyme, although this heterodimer has minimal activity when compared to the complete four-subunit BRISC complex [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
21195082
reach
"However, and in contrast to insect Abro1 and BRCC36 complexes described previously, the human Abraxas and BRCC36 subcomplex behaved as a soluble aggregate that could not be further purified, but was, nonetheless, able to form a stable monodispersed and stoichiometric assembly when purified in combination with BRCC45 and MERIT40."
28009280
reach
"While the BRCC36 and KIAA0157 heterodimer structure was not determined in complex with K63-Ub 2, the K D for binding is 2 muM, the K M for K63-Ub 2 hydrolysis is 4 muM, and the substrate binding surfa[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28587922
reach
"Comparison of the BRCC36 and KIAA0157 heterodimer structure with an inactive BRCC36 homodimer structure provides a model for understanding how this functional interplay is achieved."
26344097
biogrid
No evidence text available
22863883
biogrid
No evidence text available
19615732
reach
"Regardless, MALLS analysis of the reconstituted four-component BRCA1-A complex reported an apparent molecular mass of 280kDa (XREF_FIG B), suggestive of a dimer of Abraxas/BRCC36/BRCC45/MERIT40 heterotetramers and consonant with the " super-dimer " originally described for insect Abro1 and BRCC36 heterodimers."
28009280
reach
"To validate the BRCC36 and KIAA0157 heterodimer as being relevant in cells, we mutated direct contact residues and assessed interaction function of human BRCC36 and KIAA0157 by co-immunoprecipitation (see structure based sequence alignments in XREF_SUPPLEMENTARY and XREF_SUPPLEMENTARY for a list of equivalent residues mutated)."
26344097
ABRAXAS2 activates BRCC3.
| 6
ABRAXAS2 activates BRCC3. 6 / 8
| 6
reach
"Previous structural studies have clearly shown how the BRISC subunit Abro1 binds to and allosterically activates the DUB activity of BRCC36 and how this heterodimer further self-associates to form a " superdimeric " assembly."
28009280
reach
"We pursued crystallization of BRCC36-KIAA0157 subcomplexes from different species (H. sapiens, G. gallus, X. tropicalis, D. rerio, C. floridanus and A. thaliana) to determine the structural basis for (1) how KIAA0157 supports the catalytic function of BRCC36, and (2) how super dimerization of the minimally active BRCC36 and KIAA0157 heterodimer is mediated."
26344097
reach
"Mechanism by which KIAA0157 supports BRCC36 catalytic function."
26344097
reach
"Interestingly, although CCDC98 functions as an adaptor of BRCC36 and regulates BRCC36 activity in the nucleus, KIAA0157 mainly localizes in cytosol and activates BRCC36 in the cytoplasm."
20656690
reach
"This likely reflects the fact that the mechanism by which KIAA0157 and Abraxas support BRCC36 will differ from how CSN6 and RPN8 support and regulate the function of CSN5 and RPN11."
26344097
reach
"To understand how KIAA0157 supports the catalytic function of BRCC36, we set out to solve an inactive-state structure of BRCC36 in isolation."
26344097
BRCA1 affects BRCC3
8 1 | 1 23 1
BRCA1 binds BRCC3.
8 1 | 1 21 1
BRCA1 binds BRCC3. 10 / 22
8 1 | 1 9
reach
"Mutations that abolish the interaction between BRCA1 and BRCC36 reduce the association of BRCA2 and RAD51 to the complex, whereas mutations that abolish BARD1 interaction with BRCA1 had no effect on the association of the above proteins [XREF_BIBR]."
24832651
biogrid
No evidence text available
25184681
biogrid
No evidence text available
14636569
biogrid
No evidence text available
25252691
hprd
No evidence text available
14636569
reach
"BRCC3 directly interacts with BRCA1 at the region encompassing amino acids 502 to 1054 [XREF_BIBR], which falls within the BRCA1 DNA binding domain (amino acids 452-1079)."
26024915
reach
"Together these data indicate a direct interaction of BRCA1 and BRCC36 which is lost following cancer causing truncations of BRCA1.To directly address the role of BRE and BRCC36 in BRCC 's ubiquitin E3[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
14636569
reach
"BRCC36, one of the proteins in BRCC, directly interacts with BRCA1, and regulates the ubiquitin E3 ligase activity of BRCC."
16707425
reach
"The deubiquitinase BRCA1-BRCA2-containing complex subunit 3 (BRCC3)-mediated nucleotide-binding domain and leucine-rich repeat receptor containing a pyrin domain 3 (NLRP3) inflammasome activation participates in this progress."
34874278
trips
"Abraxas mainly localizes in the nucleus, mediating the interaction of BRCC36 with BRCA1."
21282113
BRCA1 binds BRCC3, UIMC1, and Abraxas. 6 / 6
| 6
reach
"BRCA1 encodes a protein forming the Rap80, Abraxas, Brca1, and Brcc36 complex in response to DNA damage XREF_BIBR."
29158785
reach
"UBC13 and RNF8 ubiquitin ligases control focus formation of the Rap80, Abraxas, Brca1, and Brcc36 complex in response to DNA damage."
24732096
reach
"It was proposed that the role of the BRCA1, Abraxas, RAP80, and BRCC36 complex is to limit DSB resection."
21666281
reach
"This activity and histone modification is required for the recruitment of other DDR proteins, specifically 53BP1 and the Rap80, Abraxas, Brca1, and Brcc36 complex to DSBs [167,168]."
19473885
reach
"Ubc13 and Rnf8 ubiquitin ligases control foci formation of the Rap80, Abraxas, Brca1, and Brcc36 complex in response to DNA damage."
18077395
reach
"Recruitment of the 53BP1 and Rif1 complex to DSBs promotes NHEJ repair and prevents the HR promoting BRCA1 and CtIP complex from binding to DSB sites (Chapman et al., 2013; Di Virgilio et al., 2013; F[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28943310
BRCA1 binds BRCC3, BARD1, and Abraxas. 3 / 3
| 3
reach
"Interactions of Abraxas, BACH1 and CtIP with the BRCT domain of BRCA1 are mutually exclusive, suggesting that the three proteins compete for the same binding site to form distinct BRCA1 containing complexes, of which only the Abraxas, BRCC36, BRCA1, and BARD1 complex is recruited to sites of DNA damage by RAP80 [XREF_BIBR]."
19473884
reach
"Receptor associated protein 80 (RAP80) plays a key role in recruiting the Abraxas, BRCC36, BRCA1, and BARD1 complex to DNA damage foci for DNA repair by possessing an Abraxas interacting region."
20357899
reach
"RAP80 has a key role in the recruitment of the Abraxas, BRCC36, BRCA1, and BARD1 complex to DNA-damage foci for DNA repair through specific recognition of Lys 63 linked polyubiquitinated proteins by its tandem ubiquitin interacting motifs (UIMs)."
19536136
BRCA1 binds BABAM2, BRCC3, and BARD1. 2 / 2
| 2
reach
"Furthermore, it has been demonstrated that in M-phase cells Rap80 exists in complex with the BRCA1, BARD1, BRCC36, and BRCC45 complex which is very abundant and its association is dependent on BRCC36 [XREF_BIBR]."
24832651
reach
"Fifth, through reconstitution of the BRCA1, BARD1, BRCC36, and BRE complex it demonstrates a role for BRCC36 and BRE in modulation of BRCA1 and BARD1 E3 ubiquitin ligase activity."
14636569
reach
"As discussed in Section 5.7, SUMOylation of BRCA1 is a prerequisite for BRCA1 's efficient in vitro and in vivo ubiquitylation activity [602,603], and autoubiquitylation [1038,1039] may promote this a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22743550
BRCA1 binds BRCA1, BRCC3, UIMC1, and Abraxas. 1 / 1
| 1
sparser
"After polyubiquitination of the chromatin, Brca1, a tumor suppressor protein that also possesses ubiquitin ligase activity, especially when it is complexed with Bard1, is recruited to the lesion together with Rap80, Abraxas, Brca1 and Brcc36, which form the BRCA1-A complex [ xref ]."
21037856
BRCA1 inhibits BRCC3.
| 1
BRCA1 inhibits BRCC3. 1 / 1
| 1
reach
"While truncation of BARD1 did not affect the association of any of the components of the complex, BRCA1 truncation completely abrogated the association of BRCC36 and BRE and reduced the association of[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
14636569
BRCA1 activates BRCC3.
| 1
BRCA1 activates BRCC3. 1 / 1
| 1
reach
"The experiments were performed in triplicates comparing the cells treated with siRNAs against BRCC36 or BRE, to those treated with siRNAs against BRCA1 and control siRNAs."
14636569
BRCC3 affects ABRAXAS2
10 | 22
BRCC3 binds ABRAXAS2.
10 | 21
BRCC3 binds ABRAXAS2. 10 / 34
10 | 21
reach
"These observations support the notion that the crystal structure of the BRCC36 and KIAA0157 heterodimer is reflective of both BRCC36-KIAA0157 and the BRCC36-Abraxas interactions in cells, and that perturbation of heterodimerization has far reaching consequences on the assembly of other subunits."
26344097
reach
"Structure of the BRCC36 and KIAA0157 heterodimer is functionally relevant in cells."
26344097
reach
"Furthermore, Abro1 binding to BRCC36 promotes the catalytic activity of the enzyme, although this heterodimer has minimal activity when compared to the complete four-subunit BRISC complex [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
21195082
reach
"However, and in contrast to insect Abro1 and BRCC36 complexes described previously, the human Abraxas and BRCC36 subcomplex behaved as a soluble aggregate that could not be further purified, but was, nonetheless, able to form a stable monodispersed and stoichiometric assembly when purified in combination with BRCC45 and MERIT40."
28009280
reach
"While the BRCC36 and KIAA0157 heterodimer structure was not determined in complex with K63-Ub 2, the K D for binding is 2 muM, the K M for K63-Ub 2 hydrolysis is 4 muM, and the substrate binding surfa[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28587922
reach
"Comparison of the BRCC36 and KIAA0157 heterodimer structure with an inactive BRCC36 homodimer structure provides a model for understanding how this functional interplay is achieved."
26344097
biogrid
No evidence text available
22863883
biogrid
No evidence text available
19615732
reach
"Regardless, MALLS analysis of the reconstituted four-component BRCA1-A complex reported an apparent molecular mass of 280kDa (XREF_FIG B), suggestive of a dimer of Abraxas/BRCC36/BRCC45/MERIT40 heterotetramers and consonant with the " super-dimer " originally described for insect Abro1 and BRCC36 heterodimers."
28009280
reach
"To validate the BRCC36 and KIAA0157 heterodimer as being relevant in cells, we mutated direct contact residues and assessed interaction function of human BRCC36 and KIAA0157 by co-immunoprecipitation (see structure based sequence alignments in XREF_SUPPLEMENTARY and XREF_SUPPLEMENTARY for a list of equivalent residues mutated)."
26344097
BRCC3 activates ABRAXAS2.
| 1
BRCC3 activates ABRAXAS2. 1 / 1
| 1
reach
"Like many other members of this family, BRCC36 is activated though pairing with a partner protein containing an inactive MPN domain (MPN -), Abraxas in BRCA1-A, and Abro1 in BRISC."
28009280
BRCC3 affects UIMC1
17 | 15 1
BRCC3 binds UIMC1.
17 | 13 1
BRCC3 binds UIMC1. 10 / 20
17 | 2
biogrid
No evidence text available
19615732
biogrid
No evidence text available
19261748
biogrid
No evidence text available
19305427
biogrid
No evidence text available
19202061
biogrid
No evidence text available
19015238
biogrid
No evidence text available
19261748
biogrid
No evidence text available
19261748
reach
"BRCA1 binds with its BRCT domain to phosphorylated ABRA1, which acts as a scaffold and binds BRCC36 (BRCA1 and BRCA2 containing complex subunit 36, also known as BRCC3), a deubiquitinating enzyme, BRCC45 (BRCA1 and BRCA2 containing complex subunit 45, also known as BRE), and RAP80, which is essential for the recruitment of BRCA1."
22629260
biogrid
No evidence text available
23264621
biogrid
No evidence text available
19261748
BRCA1 binds BRCC3, UIMC1, and Abraxas. 6 / 6
| 6
reach
"BRCA1 encodes a protein forming the Rap80, Abraxas, Brca1, and Brcc36 complex in response to DNA damage XREF_BIBR."
29158785
reach
"UBC13 and RNF8 ubiquitin ligases control focus formation of the Rap80, Abraxas, Brca1, and Brcc36 complex in response to DNA damage."
24732096
reach
"It was proposed that the role of the BRCA1, Abraxas, RAP80, and BRCC36 complex is to limit DSB resection."
21666281
reach
"This activity and histone modification is required for the recruitment of other DDR proteins, specifically 53BP1 and the Rap80, Abraxas, Brca1, and Brcc36 complex to DSBs [167,168]."
19473885
reach
"Ubc13 and Rnf8 ubiquitin ligases control foci formation of the Rap80, Abraxas, Brca1, and Brcc36 complex in response to DNA damage."
18077395
reach
"Recruitment of the 53BP1 and Rif1 complex to DSBs promotes NHEJ repair and prevents the HR promoting BRCA1 and CtIP complex from binding to DSB sites (Chapman et al., 2013; Di Virgilio et al., 2013; F[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28943310
BRCC3 binds UIMC1 and ABRAXAS. 2 / 2
| 2
reach
"The requirement for POH1 for generation of a devoid core can be relieved by depletion of any member of the RAP80, BRCC36, and ABRAXAS complex."
24013561
reach
"MERIT40 knockdown unravel the negative effect on the RAP80, BRCC36 and ABRAXAS complex irrespective of BRCA1."
24667604
reach
"As discussed in Section 5.7, SUMOylation of BRCA1 is a prerequisite for BRCA1 's efficient in vitro and in vivo ubiquitylation activity [602,603], and autoubiquitylation [1038,1039] may promote this a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22743550
BRCA1 binds BRCA1, BRCC3, UIMC1, and Abraxas. 1 / 1
| 1
sparser
"After polyubiquitination of the chromatin, Brca1, a tumor suppressor protein that also possesses ubiquitin ligase activity, especially when it is complexed with Bard1, is recruited to the lesion together with Rap80, Abraxas, Brca1 and Brcc36, which form the BRCA1-A complex [ xref ]."
21037856
BRCC3 binds UIMC1 and 63. 1 / 1
| 1
reach
"The Rap80 and Brcc36 complex furthermore removes lysine 63 linked polyubiquitin chains from the chromatin and is thus also involved in the termination of RNF8-Ubc13-mediated polyubiquitination once the lesion has been repaired [XREF_BIBR]."
21037856
BRCC3 binds UIMC1 and Abraxas. 1 / 1
| 1
reach
"In the proteomic analysis they performed they identified and confirmed that BRCC45 (BRE) and MERIT40 (Hspc142) are also part of this complex and that this heterodimer is responsible for the integrity of the Abraxas, Rap80, and BRCC36 complex [XREF_BIBR]."
24832651
BRCC3 deubiquitinates UIMC1.
| 1
BRCC3 deubiquitinates UIMC1. 1 / 1
| 1
reach
"BRCC36 de-ubiquitinates H2A/H2AX and RAP80."
31769469
BRCC3 activates UIMC1.
| 1
BRCC3 activates UIMC1. 1 / 1
| 1
reach
"As RAP80 binds to ubiquitin chains, we considered it likely that the ability of siRNA BRCC36 or ABRAXAS to relieve the requirement for POH1 was caused by the ability of BRCC36 and ABRAXAS to interact with and stabilize RAP80."
24013561
UIMC1 affects BRCC3
17 | 14 1
UIMC1 binds BRCC3.
17 | 13 1
BRCC3 binds UIMC1. 10 / 20
17 | 2
biogrid
No evidence text available
19615732
biogrid
No evidence text available
19261748
biogrid
No evidence text available
19305427
biogrid
No evidence text available
19202061
biogrid
No evidence text available
19015238
biogrid
No evidence text available
19261748
biogrid
No evidence text available
19261748
reach
"BRCA1 binds with its BRCT domain to phosphorylated ABRA1, which acts as a scaffold and binds BRCC36 (BRCA1 and BRCA2 containing complex subunit 36, also known as BRCC3), a deubiquitinating enzyme, BRCC45 (BRCA1 and BRCA2 containing complex subunit 45, also known as BRE), and RAP80, which is essential for the recruitment of BRCA1."
22629260
biogrid
No evidence text available
23264621
biogrid
No evidence text available
19261748
BRCA1 binds BRCC3, UIMC1, and Abraxas. 6 / 6
| 6
reach
"BRCA1 encodes a protein forming the Rap80, Abraxas, Brca1, and Brcc36 complex in response to DNA damage XREF_BIBR."
29158785
reach
"UBC13 and RNF8 ubiquitin ligases control focus formation of the Rap80, Abraxas, Brca1, and Brcc36 complex in response to DNA damage."
24732096
reach
"It was proposed that the role of the BRCA1, Abraxas, RAP80, and BRCC36 complex is to limit DSB resection."
21666281
reach
"This activity and histone modification is required for the recruitment of other DDR proteins, specifically 53BP1 and the Rap80, Abraxas, Brca1, and Brcc36 complex to DSBs [167,168]."
19473885
reach
"Ubc13 and Rnf8 ubiquitin ligases control foci formation of the Rap80, Abraxas, Brca1, and Brcc36 complex in response to DNA damage."
18077395
reach
"Recruitment of the 53BP1 and Rif1 complex to DSBs promotes NHEJ repair and prevents the HR promoting BRCA1 and CtIP complex from binding to DSB sites (Chapman et al., 2013; Di Virgilio et al., 2013; F[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28943310
BRCC3 binds UIMC1 and ABRAXAS. 2 / 2
| 2
reach
"The requirement for POH1 for generation of a devoid core can be relieved by depletion of any member of the RAP80, BRCC36, and ABRAXAS complex."
24013561
reach
"MERIT40 knockdown unravel the negative effect on the RAP80, BRCC36 and ABRAXAS complex irrespective of BRCA1."
24667604
reach
"As discussed in Section 5.7, SUMOylation of BRCA1 is a prerequisite for BRCA1 's efficient in vitro and in vivo ubiquitylation activity [602,603], and autoubiquitylation [1038,1039] may promote this a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22743550
BRCA1 binds BRCA1, BRCC3, UIMC1, and Abraxas. 1 / 1
| 1
sparser
"After polyubiquitination of the chromatin, Brca1, a tumor suppressor protein that also possesses ubiquitin ligase activity, especially when it is complexed with Bard1, is recruited to the lesion together with Rap80, Abraxas, Brca1 and Brcc36, which form the BRCA1-A complex [ xref ]."
21037856
BRCC3 binds UIMC1 and 63. 1 / 1
| 1
reach
"The Rap80 and Brcc36 complex furthermore removes lysine 63 linked polyubiquitin chains from the chromatin and is thus also involved in the termination of RNF8-Ubc13-mediated polyubiquitination once the lesion has been repaired [XREF_BIBR]."
21037856
BRCC3 binds UIMC1 and Abraxas. 1 / 1
| 1
reach
"In the proteomic analysis they performed they identified and confirmed that BRCC45 (BRE) and MERIT40 (Hspc142) are also part of this complex and that this heterodimer is responsible for the integrity of the Abraxas, Rap80, and BRCC36 complex [XREF_BIBR]."
24832651
UIMC1 activates BRCC3.
| 1
UIMC1 activates BRCC3. 1 / 1
| 1
reach
"RAP80 targets the five-member nuclear BRCC36 complex to K63-Ub chains at DNA double-strand breaks."
24075985
BABAM2 affects BRCC3
17 | 9
BABAM2 binds BRCC3.
17 | 8
BABAM2 binds BRCC3. 10 / 19
17 | 2
biogrid
No evidence text available
19261749
biogrid
No evidence text available
19615732
biogrid
No evidence text available
14636569
biogrid
No evidence text available
20032457
biogrid
No evidence text available
21282113
biogrid
No evidence text available
20656689
biogrid
No evidence text available
14636569
biogrid
No evidence text available
19261748
biogrid
No evidence text available
19261746
biogrid
No evidence text available
19261749
BABAM2 binds BRCC3 and BABAM1. 4 / 4
| 4
reach
"Our LC-MS analysis and immunoprecipitation data showed that tankyrase was associated with the BRE-BRCC36-MERIT40 complex (or the BRCA1-A complex) via MERIT40."
30533199
reach
"In this study, we performed liquid chromatography-mass spectrometry (LC-MS) analysis and identified the MERIT40-BRE-BRCC36 complex as tankyrase-binding proteins."
30533199
reach
"To explore the novel functions of tankyrase, we performed liquid chromatography-mass spectrometry analysis and identified the BRE, BRCC36, and MERIT40 complex, a regulator of homologous recombination, as tankyrase binding proteins."
30533199
reach
"To explore the novel functions of tankyrase, we performed liquid chromatography-mass spectrometry analysis and identified the BRE-BRCC36-MERIT40 complex, a regulator of homologous recombination, as tankyrase-binding proteins."
30533199
BRCA1 binds BABAM2, BRCC3, and BARD1. 2 / 2
| 2
reach
"Furthermore, it has been demonstrated that in M-phase cells Rap80 exists in complex with the BRCA1, BARD1, BRCC36, and BRCC45 complex which is very abundant and its association is dependent on BRCC36 [XREF_BIBR]."
24832651
reach
"Fifth, through reconstitution of the BRCA1, BARD1, BRCC36, and BRE complex it demonstrates a role for BRCC36 and BRE in modulation of BRCA1 and BARD1 E3 ubiquitin ligase activity."
14636569
BABAM2 increases the amount of BRCC3.
| 1
Modified BABAM2 increases the amount of BRCC3. 1 / 1
| 1
reach
"Expression of HA-BRE or HA- FLDelta123 BRE restores RAP80 and BRCC36 protein level after mouse BRE knockdown, indicating that HA- FLDelta123 BRE does not affect the key function of BRE."
29416040
BRCC3 affects ABRAXAS1
18 | 2
biogrid
No evidence text available
21282113
biogrid
No evidence text available
19261749
biogrid
No evidence text available
19261749
biogrid
No evidence text available
19261748
biogrid
No evidence text available
18077395
biogrid
No evidence text available
19261748
biogrid
No evidence text available
19261748
biogrid
No evidence text available
19261748
biogrid
No evidence text available
20656689
biogrid
No evidence text available
19261746
reach
"As discussed in Section 5.7, SUMOylation of BRCA1 is a prerequisite for BRCA1 's efficient in vitro and in vivo ubiquitylation activity [602,603], and autoubiquitylation [1038,1039] may promote this a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22743550
BRCC3 binds phosphorylated ABRAXAS1. 1 / 1
| 1
reach
"BRCA1 binds with its BRCT domain to phosphorylated ABRA1, which acts as a scaffold and binds BRCC36 (BRCA1 and BRCA2 containing complex subunit 36, also known as BRCC3), a deubiquitinating enzyme, BRCC45 (BRCA1 and BRCA2 containing complex subunit 45, also known as BRE), and RAP80, which is essential for the recruitment of BRCA1."
22629260
BRCC3 affects BABAM1
14 | 5
BRCC3 binds BABAM1. 10 / 15
14 | 1
biogrid
No evidence text available
19261746
biogrid
No evidence text available
19615732
biogrid
No evidence text available
19261749
biogrid
No evidence text available
19261748
biogrid
No evidence text available
19615732
biogrid
No evidence text available
21282113
biogrid
No evidence text available
19261749
biogrid
No evidence text available
19261746
biogrid
No evidence text available
19261748
biogrid
No evidence text available
26186194
BABAM2 binds BRCC3 and BABAM1. 4 / 4
| 4
reach
"Our LC-MS analysis and immunoprecipitation data showed that tankyrase was associated with the BRE-BRCC36-MERIT40 complex (or the BRCA1-A complex) via MERIT40."
30533199
reach
"In this study, we performed liquid chromatography-mass spectrometry (LC-MS) analysis and identified the MERIT40-BRE-BRCC36 complex as tankyrase-binding proteins."
30533199
reach
"To explore the novel functions of tankyrase, we performed liquid chromatography-mass spectrometry analysis and identified the BRE, BRCC36, and MERIT40 complex, a regulator of homologous recombination, as tankyrase binding proteins."
30533199
reach
"To explore the novel functions of tankyrase, we performed liquid chromatography-mass spectrometry analysis and identified the BRE-BRCC36-MERIT40 complex, a regulator of homologous recombination, as tankyrase-binding proteins."
30533199
Abraxas affects BRCC3
| 16 1
Abraxas binds BRCC3.
| 14 1
BRCA1 binds BRCC3, UIMC1, and Abraxas. 6 / 6
| 6
reach
"BRCA1 encodes a protein forming the Rap80, Abraxas, Brca1, and Brcc36 complex in response to DNA damage XREF_BIBR."
29158785
reach
"UBC13 and RNF8 ubiquitin ligases control focus formation of the Rap80, Abraxas, Brca1, and Brcc36 complex in response to DNA damage."
24732096
reach
"It was proposed that the role of the BRCA1, Abraxas, RAP80, and BRCC36 complex is to limit DSB resection."
21666281
reach
"This activity and histone modification is required for the recruitment of other DDR proteins, specifically 53BP1 and the Rap80, Abraxas, Brca1, and Brcc36 complex to DSBs [167,168]."
19473885
reach
"Ubc13 and Rnf8 ubiquitin ligases control foci formation of the Rap80, Abraxas, Brca1, and Brcc36 complex in response to DNA damage."
18077395
reach
"Recruitment of the 53BP1 and Rif1 complex to DSBs promotes NHEJ repair and prevents the HR promoting BRCA1 and CtIP complex from binding to DSB sites (Chapman et al., 2013; Di Virgilio et al., 2013; F[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28943310
BRCC3 binds Abraxas. 4 / 4
| 4
reach
"However, since both Abraxas and Abro1 each bind to both BRCC36 and BRCC45 in their respective DUB complexes, we surmised that the interaction surfaces for these components should show the highest degree of conservation between the two paralogs."
28009280
reach
"Abraxas and Brcc36 associate through coiled-coil domains on each protein."
18077395
reach
"The structure of an active core complex comprising twoAbraxas/BRCC36/BRCC45/MERIT40 tetramers determined by negative-stain electron microscopy (EM) reveals a distorted V-shape architecture in which a dimer of Abraxas and BRCC36 heterodimers sits at the base, with BRCC45 and Merit40 pairs occupying each arm."
28009280
reach
"Thus, it seems likely that the apparent requirement of BRCC45 for DUB activity of the BRCA1-A complex, but not BRISC, is not due to major structural differences between the two complexes, but merely reflects a specific stabilizing effect of BRCC45 on Abraxas and BRCC36 complexes that is not required by Abro1 and BRCC36."
28009280
BRCA1 binds BRCC3, BARD1, and Abraxas. 3 / 3
| 3
reach
"Interactions of Abraxas, BACH1 and CtIP with the BRCT domain of BRCA1 are mutually exclusive, suggesting that the three proteins compete for the same binding site to form distinct BRCA1 containing complexes, of which only the Abraxas, BRCC36, BRCA1, and BARD1 complex is recruited to sites of DNA damage by RAP80 [XREF_BIBR]."
19473884
reach
"Receptor associated protein 80 (RAP80) plays a key role in recruiting the Abraxas, BRCC36, BRCA1, and BARD1 complex to DNA damage foci for DNA repair by possessing an Abraxas interacting region."
20357899
reach
"RAP80 has a key role in the recruitment of the Abraxas, BRCC36, BRCA1, and BARD1 complex to DNA-damage foci for DNA repair through specific recognition of Lys 63 linked polyubiquitinated proteins by its tandem ubiquitin interacting motifs (UIMs)."
19536136
BRCA1 binds BRCA1, BRCC3, UIMC1, and Abraxas. 1 / 1
| 1
sparser
"After polyubiquitination of the chromatin, Brca1, a tumor suppressor protein that also possesses ubiquitin ligase activity, especially when it is complexed with Bard1, is recruited to the lesion together with Rap80, Abraxas, Brca1 and Brcc36, which form the BRCA1-A complex [ xref ]."
21037856
BRCC3 binds UIMC1 and Abraxas. 1 / 1
| 1
reach
"In the proteomic analysis they performed they identified and confirmed that BRCC45 (BRE) and MERIT40 (Hspc142) are also part of this complex and that this heterodimer is responsible for the integrity of the Abraxas, Rap80, and BRCC36 complex [XREF_BIBR]."
24832651
Abraxas activates BRCC3.
| 2
Abraxas activates BRCC3. 2 / 2
| 2
reach
"Abraxas mainly localizes in the nucleus, mediating the interaction of BRCC36 with BRCA1."
21282113
reach
"This likely reflects the fact that the mechanism by which KIAA0157 and Abraxas support BRCC36 will differ from how CSN6 and RPN8 support and regulate the function of CSN5 and RPN11."
26344097
BRCC3 affects Abraxas
| 15 1
BRCC3 binds Abraxas.
| 14 1
BRCA1 binds BRCC3, UIMC1, and Abraxas. 6 / 6
| 6
reach
"BRCA1 encodes a protein forming the Rap80, Abraxas, Brca1, and Brcc36 complex in response to DNA damage XREF_BIBR."
29158785
reach
"UBC13 and RNF8 ubiquitin ligases control focus formation of the Rap80, Abraxas, Brca1, and Brcc36 complex in response to DNA damage."
24732096
reach
"It was proposed that the role of the BRCA1, Abraxas, RAP80, and BRCC36 complex is to limit DSB resection."
21666281
reach
"This activity and histone modification is required for the recruitment of other DDR proteins, specifically 53BP1 and the Rap80, Abraxas, Brca1, and Brcc36 complex to DSBs [167,168]."
19473885
reach
"Ubc13 and Rnf8 ubiquitin ligases control foci formation of the Rap80, Abraxas, Brca1, and Brcc36 complex in response to DNA damage."
18077395
reach
"Recruitment of the 53BP1 and Rif1 complex to DSBs promotes NHEJ repair and prevents the HR promoting BRCA1 and CtIP complex from binding to DSB sites (Chapman et al., 2013; Di Virgilio et al., 2013; F[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28943310
BRCC3 binds Abraxas. 4 / 4
| 4
reach
"However, since both Abraxas and Abro1 each bind to both BRCC36 and BRCC45 in their respective DUB complexes, we surmised that the interaction surfaces for these components should show the highest degree of conservation between the two paralogs."
28009280
reach
"Abraxas and Brcc36 associate through coiled-coil domains on each protein."
18077395
reach
"The structure of an active core complex comprising twoAbraxas/BRCC36/BRCC45/MERIT40 tetramers determined by negative-stain electron microscopy (EM) reveals a distorted V-shape architecture in which a dimer of Abraxas and BRCC36 heterodimers sits at the base, with BRCC45 and Merit40 pairs occupying each arm."
28009280
reach
"Thus, it seems likely that the apparent requirement of BRCC45 for DUB activity of the BRCA1-A complex, but not BRISC, is not due to major structural differences between the two complexes, but merely reflects a specific stabilizing effect of BRCC45 on Abraxas and BRCC36 complexes that is not required by Abro1 and BRCC36."
28009280
BRCA1 binds BRCC3, BARD1, and Abraxas. 3 / 3
| 3
reach
"Interactions of Abraxas, BACH1 and CtIP with the BRCT domain of BRCA1 are mutually exclusive, suggesting that the three proteins compete for the same binding site to form distinct BRCA1 containing complexes, of which only the Abraxas, BRCC36, BRCA1, and BARD1 complex is recruited to sites of DNA damage by RAP80 [XREF_BIBR]."
19473884
reach
"Receptor associated protein 80 (RAP80) plays a key role in recruiting the Abraxas, BRCC36, BRCA1, and BARD1 complex to DNA damage foci for DNA repair by possessing an Abraxas interacting region."
20357899
reach
"RAP80 has a key role in the recruitment of the Abraxas, BRCC36, BRCA1, and BARD1 complex to DNA-damage foci for DNA repair through specific recognition of Lys 63 linked polyubiquitinated proteins by its tandem ubiquitin interacting motifs (UIMs)."
19536136
BRCA1 binds BRCA1, BRCC3, UIMC1, and Abraxas. 1 / 1
| 1
sparser
"After polyubiquitination of the chromatin, Brca1, a tumor suppressor protein that also possesses ubiquitin ligase activity, especially when it is complexed with Bard1, is recruited to the lesion together with Rap80, Abraxas, Brca1 and Brcc36, which form the BRCA1-A complex [ xref ]."
21037856
BRCC3 binds UIMC1 and Abraxas. 1 / 1
| 1
reach
"In the proteomic analysis they performed they identified and confirmed that BRCC45 (BRE) and MERIT40 (Hspc142) are also part of this complex and that this heterodimer is responsible for the integrity of the Abraxas, Rap80, and BRCC36 complex [XREF_BIBR]."
24832651
BRCC3 activates Abraxas.
| 1
BRCC3 activates Abraxas. 1 / 1
| 1
reach
"Like many other members of this family, BRCC36 is activated though pairing with a partner protein containing an inactive MPN domain (MPN -), Abraxas in BRCA1-A, and Abro1 in BRISC."
28009280
BRCC3 affects BARD1
5 | 9
BRCC3 binds BARD1.
5 | 6
BRCC3 binds BARD1. 5 / 5
5 |
biogrid
No evidence text available
14636569
biogrid
No evidence text available
17664283
biogrid
No evidence text available
14636569
biogrid
No evidence text available
17664283
biogrid
No evidence text available
17525341
BRCA1 binds BRCC3, BARD1, and Abraxas. 3 / 3
| 3
reach
"Interactions of Abraxas, BACH1 and CtIP with the BRCT domain of BRCA1 are mutually exclusive, suggesting that the three proteins compete for the same binding site to form distinct BRCA1 containing complexes, of which only the Abraxas, BRCC36, BRCA1, and BARD1 complex is recruited to sites of DNA damage by RAP80 [XREF_BIBR]."
19473884
reach
"Receptor associated protein 80 (RAP80) plays a key role in recruiting the Abraxas, BRCC36, BRCA1, and BARD1 complex to DNA damage foci for DNA repair by possessing an Abraxas interacting region."
20357899
reach
"RAP80 has a key role in the recruitment of the Abraxas, BRCC36, BRCA1, and BARD1 complex to DNA-damage foci for DNA repair through specific recognition of Lys 63 linked polyubiquitinated proteins by its tandem ubiquitin interacting motifs (UIMs)."
19536136
BRCA1 binds BABAM2, BRCC3, and BARD1. 2 / 2
| 2
reach
"Furthermore, it has been demonstrated that in M-phase cells Rap80 exists in complex with the BRCA1, BARD1, BRCC36, and BRCC45 complex which is very abundant and its association is dependent on BRCC36 [XREF_BIBR]."
24832651
reach
"Fifth, through reconstitution of the BRCA1, BARD1, BRCC36, and BRE complex it demonstrates a role for BRCC36 and BRE in modulation of BRCA1 and BARD1 E3 ubiquitin ligase activity."
14636569
reach
"As discussed in Section 5.7, SUMOylation of BRCA1 is a prerequisite for BRCA1 's efficient in vitro and in vivo ubiquitylation activity [602,603], and autoubiquitylation [1038,1039] may promote this a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22743550
BRCC3 activates BARD1.
| 2
BRCC3 activates BARD1. 2 / 2
| 2
reach
"But beside the canonical role of deubiquitinating enzymes in antagonizing ubiquitin ligase activity, BRCC36 also enhances BRCA1 and BARD1 E3 ubiquitin ligase activity."
20817926
reach
"These results indicate that the two new subunits, BRCC36 and BRE, potentiate the E3 ligase activity of BRCA1 and BARD1."
14636569
BRCC3 ubiquitinates BARD1.
| 1
BRCC3 leads to the ubiquitination of BARD1. 1 / 1
| 1
reach
"Further, BRCC36 and BRCC45 enhance the E3 ubiquitin ligase activity of the multiprotein complex BRCA1, BARD1, and BRCA2 and ubiquitination of p53 in vitro."
16854521
BRCA1 affects Abraxas
| 9 1
BRCA1 binds BRCC3, UIMC1, and Abraxas. 6 / 6
| 6
reach
"BRCA1 encodes a protein forming the Rap80, Abraxas, Brca1, and Brcc36 complex in response to DNA damage XREF_BIBR."
29158785
reach
"UBC13 and RNF8 ubiquitin ligases control focus formation of the Rap80, Abraxas, Brca1, and Brcc36 complex in response to DNA damage."
24732096
reach
"It was proposed that the role of the BRCA1, Abraxas, RAP80, and BRCC36 complex is to limit DSB resection."
21666281
reach
"This activity and histone modification is required for the recruitment of other DDR proteins, specifically 53BP1 and the Rap80, Abraxas, Brca1, and Brcc36 complex to DSBs [167,168]."
19473885
reach
"Ubc13 and Rnf8 ubiquitin ligases control foci formation of the Rap80, Abraxas, Brca1, and Brcc36 complex in response to DNA damage."
18077395
reach
"Recruitment of the 53BP1 and Rif1 complex to DSBs promotes NHEJ repair and prevents the HR promoting BRCA1 and CtIP complex from binding to DSB sites (Chapman et al., 2013; Di Virgilio et al., 2013; F[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28943310
BRCA1 binds BRCC3, BARD1, and Abraxas. 3 / 3
| 3
reach
"Interactions of Abraxas, BACH1 and CtIP with the BRCT domain of BRCA1 are mutually exclusive, suggesting that the three proteins compete for the same binding site to form distinct BRCA1 containing complexes, of which only the Abraxas, BRCC36, BRCA1, and BARD1 complex is recruited to sites of DNA damage by RAP80 [XREF_BIBR]."
19473884
reach
"Receptor associated protein 80 (RAP80) plays a key role in recruiting the Abraxas, BRCC36, BRCA1, and BARD1 complex to DNA damage foci for DNA repair by possessing an Abraxas interacting region."
20357899
reach
"RAP80 has a key role in the recruitment of the Abraxas, BRCC36, BRCA1, and BARD1 complex to DNA-damage foci for DNA repair through specific recognition of Lys 63 linked polyubiquitinated proteins by its tandem ubiquitin interacting motifs (UIMs)."
19536136
BRCA1 binds BRCA1, BRCC3, UIMC1, and Abraxas. 1 / 1
| 1
sparser
"After polyubiquitination of the chromatin, Brca1, a tumor suppressor protein that also possesses ubiquitin ligase activity, especially when it is complexed with Bard1, is recruited to the lesion together with Rap80, Abraxas, Brca1 and Brcc36, which form the BRCA1-A complex [ xref ]."
21037856
BRCC3 affects TRAF2
| 9
BRCC3 activates TRAF2.
| 7
BRCC3 activates TRAF2. 7 / 7
| 7
reach
"BRCC3 Promotes Tumorigenesis of Bladder Cancer by Activating the NF-kappaB Signaling Pathway Through Targeting TRAF2."
34604222
reach
"Our results indicate that high BRCC3 expression activates NF-kappaB signaling by targeting TRAF2 for activation, which in turn facilitates tumorigenesis in bladder cancer."
34604222
reach
"Our results indicate that high BRCC3 expression activates NF-κB signaling by targeting TRAF2 for activation, which in turn facilitates tumorigenesis in bladder cancer."
34604222
reach
"Here, we found that high expression of BRCC3 promoted tumorigenesis through targeting the TRAF2 protein."
34604222
reach
"We found that BRCC3 increased the activation NF-κB signaling pathway together with the upstream molecules TNFR and TRAF2 (Figure 5A)."
34604222
reach
"BRCC3 binds to and synergizes with TRAF2 to activate NF-kappaB signaling."
34604222
reach
"BRCC3 binds to and synergizes with TRAF2 to activate NF-κB signaling."
34604222
BRCC3 binds TRAF2.
| 2
TRAF2 binds BRCC3. 2 / 2
| 2
reach
"We identified BRCC3 bound to TRAF2 to activate NF-κB signaling."
34604222
reach
"Through co-transfecting of the node protein of the NF-κB pathway, we reported that BRCC3 maximizes the potential of TRAF2 to activate the NF-κB pathway, and further exploration showed that BRCC3 binds to TRAF2."
34604222
UIMC1 affects BRCA1
| 7 1
BRCA1 binds BRCC3, UIMC1, and Abraxas. 6 / 6
| 6
reach
"BRCA1 encodes a protein forming the Rap80, Abraxas, Brca1, and Brcc36 complex in response to DNA damage XREF_BIBR."
29158785
reach
"UBC13 and RNF8 ubiquitin ligases control focus formation of the Rap80, Abraxas, Brca1, and Brcc36 complex in response to DNA damage."
24732096
reach
"It was proposed that the role of the BRCA1, Abraxas, RAP80, and BRCC36 complex is to limit DSB resection."
21666281
reach
"This activity and histone modification is required for the recruitment of other DDR proteins, specifically 53BP1 and the Rap80, Abraxas, Brca1, and Brcc36 complex to DSBs [167,168]."
19473885
reach
"Ubc13 and Rnf8 ubiquitin ligases control foci formation of the Rap80, Abraxas, Brca1, and Brcc36 complex in response to DNA damage."
18077395
reach
"Recruitment of the 53BP1 and Rif1 complex to DSBs promotes NHEJ repair and prevents the HR promoting BRCA1 and CtIP complex from binding to DSB sites (Chapman et al., 2013; Di Virgilio et al., 2013; F[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28943310
reach
"As discussed in Section 5.7, SUMOylation of BRCA1 is a prerequisite for BRCA1 's efficient in vitro and in vivo ubiquitylation activity [602,603], and autoubiquitylation [1038,1039] may promote this a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22743550
BRCA1 binds BRCA1, BRCC3, UIMC1, and Abraxas. 1 / 1
| 1
sparser
"After polyubiquitination of the chromatin, Brca1, a tumor suppressor protein that also possesses ubiquitin ligase activity, especially when it is complexed with Bard1, is recruited to the lesion together with Rap80, Abraxas, Brca1 and Brcc36, which form the BRCA1-A complex [ xref ]."
21037856
UIMC1 affects Abraxas
| 7 1
BRCA1 binds BRCC3, UIMC1, and Abraxas. 6 / 6
| 6
reach
"BRCA1 encodes a protein forming the Rap80, Abraxas, Brca1, and Brcc36 complex in response to DNA damage XREF_BIBR."
29158785
reach
"UBC13 and RNF8 ubiquitin ligases control focus formation of the Rap80, Abraxas, Brca1, and Brcc36 complex in response to DNA damage."
24732096
reach
"It was proposed that the role of the BRCA1, Abraxas, RAP80, and BRCC36 complex is to limit DSB resection."
21666281
reach
"This activity and histone modification is required for the recruitment of other DDR proteins, specifically 53BP1 and the Rap80, Abraxas, Brca1, and Brcc36 complex to DSBs [167,168]."
19473885
reach
"Ubc13 and Rnf8 ubiquitin ligases control foci formation of the Rap80, Abraxas, Brca1, and Brcc36 complex in response to DNA damage."
18077395
reach
"Recruitment of the 53BP1 and Rif1 complex to DSBs promotes NHEJ repair and prevents the HR promoting BRCA1 and CtIP complex from binding to DSB sites (Chapman et al., 2013; Di Virgilio et al., 2013; F[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28943310
BRCA1 binds BRCA1, BRCC3, UIMC1, and Abraxas. 1 / 1
| 1
sparser
"After polyubiquitination of the chromatin, Brca1, a tumor suppressor protein that also possesses ubiquitin ligase activity, especially when it is complexed with Bard1, is recruited to the lesion together with Rap80, Abraxas, Brca1 and Brcc36, which form the BRCA1-A complex [ xref ]."
21037856
BRCC3 binds UIMC1 and Abraxas. 1 / 1
| 1
reach
"In the proteomic analysis they performed they identified and confirmed that BRCC45 (BRE) and MERIT40 (Hspc142) are also part of this complex and that this heterodimer is responsible for the integrity of the Abraxas, Rap80, and BRCC36 complex [XREF_BIBR]."
24832651
SHMT2 affects BRCC3
2 | 6
SHMT2 binds BRCC3.
2 | 3
SHMT2 binds BRCC3. 5 / 5
2 | 3
biogrid
No evidence text available
28514442
reach
"Interestingly, we revealed that BRCC36 knockdown decreased beta-catenin expression in CRC cells, suggesting that binding between SHMT2 and BRCC36 may direct BRCC36 activity towards K63-Ub chains conjugated to beta-catenin in CRC cells."
33456583
reach
"SHMT2 reportedly binds to BRCC36 and acts as an apparent competitive inhibitor for BRCC36 XREF_BIBR."
33456583
biogrid
No evidence text available
19615732
reach
"Given that SHMT2 and BRCC36 complexes work together to promote K-63 ubiquitin deubiquitination XREF_BIBR, we investigated whether BRCC36 is involved in beta-catenin deubiquitination."
33456583
SHMT2 activates BRCC3.
| 3
SHMT2 activates BRCC3. 2 / 2
| 2
reach
"Cytosolic SHMT2 was known to direct the BRCC36 containing complex (BRISC, a complex with deubiquitination activity) to deubiquitinate type I IFN receptor chain 1 (IFNalphaR1) and thus decrease the internalization and increase the stability of IFNalphaR1."
30819897
reach
"Cytoplasmic SHMT2 directs BRCC36 isopeptidase complex (BRISC) activity at K63-Ub chains combined with the type 1 interferon receptor chain 1 (IFNAR1)."
33456583
SHMT2 bound to BRCC3 activates BRCC3. 1 / 1
| 1
reach
"Interestingly, we revealed that BRCC36 knockdown decreased beta-catenin expression in CRC cells, suggesting that binding between SHMT2 and BRCC36 may direct BRCC36 activity towards K63-Ub chains conjugated to beta-catenin in CRC cells."
33456583
NLRP3 affects BRCC3
| 6 2
NLRP3 binds BRCC3.
| 4 2
NLRP3 binds BRCC3. 3 / 3
| 3
reach
"This work suggested that BRCC3 directly interacted with NLRP3, and its presence was required for appropriate NLRP3 inflammasome formation."
31679183
reach
"BRCC3 can directly bind to NLRP3 and favors NLRP3 inflammasome activation through its deubiquitination."
| PMC
reach
"Co-IP experiments confirmed the interaction between BRCC3 and NLRP3."
34874278
BRCC3 binds NLRP3. 2 / 2
| 2
isi
"VDR can physically bind NLRP3 and block the association of NLRP3 with BRCC3."
31866999
isi
"This was mediated by enhanced deubiquitination of NLRP3 via binding with deubiquitinases BRCC3 and JOSD2, which are highly expressed in myeloid cells."
32941940
Ubiquitinated NLRP3 binds BRCC3. 1 / 1
| 1
reach
"Consistent with a regulatory role of BRCC3 with NLRP3 inflammasome, we found that endogenous BRCC3 coimmunoprecipitated with Flag-NLRP3 from NG5 cell lysates and with endogenous NLRP3 from LPS primed [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23246432
NLRP3 inhibits BRCC3.
| 1
NLRP3 inhibits BRCC3. 1 / 1
| 1
reach
"Another possibility is that because BRCC3 is the sole identified host deubiquitinase of NLRP3, the association of NleA and NLRP3 may impede the access of BRCC3 to the sensor protein."
27617233
NLRP3 activates BRCC3.
| 1
NLRP3 activates BRCC3. 1 / 1
| 1
reach
"A posttranscriptional modification, such as NLRP3 deubiquitination mediated by BRCA1/BRCA2-containing complex subunit 3 (BRCC3), is required for NLRP3 activation (signal 2) [67, 68]."
31687078
BRCC3 activates cell differentiation.
| 6
BRCC3 activates cell differentiation. 6 / 6
| 6
reach
"In contrast, the knockdown of BRCC3 (BRCC3-KD) through the application of lentivirus mediated shRNA delivery system into OPCs suppressed OL differentiation by decreasing MBP expression and PLP production."
31184779
reach
"Results showed that XAV939 inhibited the ALP activation and formation of calcified nodules induced by BRCC3 siRNA, suggesting that beta-catenin signaling mediated the BRCC3 siRNA induced osteogenic differentiation (XREF_FIG)."
30834083
reach
"In this study, we found depletion of BRCC36 promoted the differentiation and activation of osteoblast, and beta-catenin mediated this effect."
30834083
reach
"BRCC3 siRNA promoted differentiation of osteoblasts and up-regulated beta-catenin After transfected with BRCC3 siRNA and cultured for 21 days, the cells were stained with ALP and ARS (XREF_FIG)."
30834083
reach
"Moreover, depletion of BRCC3 promoted osteogenic differentiation of osteoblast through up-regulated beta-catenin expression, whereas opposite effects were observed after BRCC3 overexpression."
30834083
reach
"XAV939 reversed the BRCC3 siRNA induced osteogenic differentiation."
30834083
BRCC3 inhibits cell differentiation.
| 2
reach
"Inhibition of beta-catenin reversed BRCC3 siRNA induced osteogenic differentiation To test the role of beta-catenin in BRCC3 siRNA actions, cells were treated with XAV939 to inhibit the activation of beta-catenin signaling."
30834083
Modified BRCC3 inhibits cell differentiation. 1 / 1
| 1
reach
"Additionally, the differentiation and beta-catenin expression were suppressed by BRCC3 overexpression."
30834083
BRCC3 affects NUMA1
2 1 | 2
BRCC3 binds NUMA1.
2 |
BRCC3 binds NUMA1. 2 / 3
2 |
biogrid
No evidence text available
26195665
biogrid
No evidence text available
26195665
BRCC3 inhibits NUMA1.
| 1
BRCC3 inhibits NUMA1. 1 / 2
| 1
reach
"However, in BRCC36 silenced cells, a large proportion of NuMA aggregates was retained in the peripheral areas distant from the spindle poles (XREF_FIG; 25-30 min), and supernumerary poles were formed, indicating that depletion of BRCC36 decreases the incorporation of NuMA into spindle poles during mitosis, presumably by aberrant dynamic interaction between NuMA and its partner dynein."
26195665
BRCC3 activates NUMA1.
| 1
BRCC3 activates NUMA1. 1 / 2
| 1
reach
"Immunoprecipitation revealed that depletion of ABRO1 or BRCC36 increased the interaction of NuMA with dynein, as well as with importin-beta in HeLa cells (XREF_FIG), indicating that BRISCs negatively regulate the association of NuMA with dynein and importin-beta."
26195665
BRCC3 deubiquitinates NUMA1.
1 |
BRCC3 deubiquitinates NUMA1. 1 / 1
1 |
ubibrowser
"importantly, BRISC promotes the assembly of functional bipolar spindle by deubiquitinating the essential spindle assembly factor nuclear mitotic apparatus (NuMA)."
26195665
BRCA1 affects UIMC1
| 7 1
BRCA1 binds BRCC3, UIMC1, and Abraxas. 6 / 6
| 6
reach
"BRCA1 encodes a protein forming the Rap80, Abraxas, Brca1, and Brcc36 complex in response to DNA damage XREF_BIBR."
29158785
reach
"UBC13 and RNF8 ubiquitin ligases control focus formation of the Rap80, Abraxas, Brca1, and Brcc36 complex in response to DNA damage."
24732096
reach
"It was proposed that the role of the BRCA1, Abraxas, RAP80, and BRCC36 complex is to limit DSB resection."
21666281
reach
"This activity and histone modification is required for the recruitment of other DDR proteins, specifically 53BP1 and the Rap80, Abraxas, Brca1, and Brcc36 complex to DSBs [167,168]."
19473885
reach
"Ubc13 and Rnf8 ubiquitin ligases control foci formation of the Rap80, Abraxas, Brca1, and Brcc36 complex in response to DNA damage."
18077395
reach
"Recruitment of the 53BP1 and Rif1 complex to DSBs promotes NHEJ repair and prevents the HR promoting BRCA1 and CtIP complex from binding to DSB sites (Chapman et al., 2013; Di Virgilio et al., 2013; F[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28943310
reach
"As discussed in Section 5.7, SUMOylation of BRCA1 is a prerequisite for BRCA1 's efficient in vitro and in vivo ubiquitylation activity [602,603], and autoubiquitylation [1038,1039] may promote this a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22743550
BRCA1 binds BRCA1, BRCC3, UIMC1, and Abraxas. 1 / 1
| 1
sparser
"After polyubiquitination of the chromatin, Brca1, a tumor suppressor protein that also possesses ubiquitin ligase activity, especially when it is complexed with Bard1, is recruited to the lesion together with Rap80, Abraxas, Brca1 and Brcc36, which form the BRCA1-A complex [ xref ]."
21037856
Abraxas affects UIMC1
| 7 1
BRCA1 binds BRCC3, UIMC1, and Abraxas. 6 / 6
| 6
reach
"BRCA1 encodes a protein forming the Rap80, Abraxas, Brca1, and Brcc36 complex in response to DNA damage XREF_BIBR."
29158785
reach
"UBC13 and RNF8 ubiquitin ligases control focus formation of the Rap80, Abraxas, Brca1, and Brcc36 complex in response to DNA damage."
24732096
reach
"It was proposed that the role of the BRCA1, Abraxas, RAP80, and BRCC36 complex is to limit DSB resection."
21666281
reach
"This activity and histone modification is required for the recruitment of other DDR proteins, specifically 53BP1 and the Rap80, Abraxas, Brca1, and Brcc36 complex to DSBs [167,168]."
19473885
reach
"Ubc13 and Rnf8 ubiquitin ligases control foci formation of the Rap80, Abraxas, Brca1, and Brcc36 complex in response to DNA damage."
18077395
reach
"Recruitment of the 53BP1 and Rif1 complex to DSBs promotes NHEJ repair and prevents the HR promoting BRCA1 and CtIP complex from binding to DSB sites (Chapman et al., 2013; Di Virgilio et al., 2013; F[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28943310
BRCA1 binds BRCA1, BRCC3, UIMC1, and Abraxas. 1 / 1
| 1
sparser
"After polyubiquitination of the chromatin, Brca1, a tumor suppressor protein that also possesses ubiquitin ligase activity, especially when it is complexed with Bard1, is recruited to the lesion together with Rap80, Abraxas, Brca1 and Brcc36, which form the BRCA1-A complex [ xref ]."
21037856
BRCC3 binds UIMC1 and Abraxas. 1 / 1
| 1
reach
"In the proteomic analysis they performed they identified and confirmed that BRCC45 (BRE) and MERIT40 (Hspc142) are also part of this complex and that this heterodimer is responsible for the integrity of the Abraxas, Rap80, and BRCC36 complex [XREF_BIBR]."
24832651
CDK5 affects BRCC3
| 7
CDK5 phosphorylates BRCC3.
| 5
CDK5 phosphorylates BRCC3. 5 / 5
| 5
reach
"It has been demonstrated that protein kinase Cdk5 can phosphorylate the deubiquitinating enzyme BRCC3 in vitro, which provides new data for further study on the mechanism of neurodegeneration."
35503584
reach
"Phosphorylation of BRCC3 by Cdk5 was predicted by GPS 5.0 software."
35503584
reach
"Phosphorylation of BRCC3 fusion protein by Cdk5 in vitro was detected by mass spectrometry and Western blotting."
35503584
reach
"In vitro kinase assay, Western blotting, and mass spectrometry showed that Cdk5 can phosphorylate BRCC3."
35503584
reach
"Here we studied whether Cdk5 phosphorylates BRCC3."
35503584
CDK5 increases the amount of BRCC3.
| 1
CDK5 increases the amount of BRCC3. 1 / 1
| 1
reach
"Interestingly, upregulating cyclin dependent kinase 5 (Cdk5) increased the expression of BRCC3 in HEK293cell, while inhibition of Cdk5 decreased the upregulated BRCC3 level in MPP + -induced PD cell model."
31787240
CDK5 binds BRCC3.
| 1
CDK5 binds BRCC3. 1 / 1
| 1
reach
"The interaction between Cdk5 and BRCC3 was further confirmed by immunoprecipitation."
31787240
BRCC3 affects Carcinogenesis
| 2 5
BRCC3 activates Carcinogenesis. 7 / 7
| 2 5
eidos
"BRCC3 Promotes Tumorigenesis of Bladder Cancer by Activating the NF-kappaB Signaling Pathway Through Targeting TRAF2 ."
34604222
reach
"BRCC3 over-expression promoted tumorigenesis and was not associated with the enzymatic activity of BRCC3."
34604222
reach
"BRCC3 Promotes Tumorigenesis of Bladder Cancer by Activating the NF-kappaB Signaling Pathway Through Targeting TRAF2."
34604222
eidos
"Here , we found that high expression of BRCC3 promoted tumorigenesis through targeting the TRAF2 protein ."
34604222
reach
"Our findings showed BRCC3 plays a crucial role in facilitating the development and progression of bladder cancer.To reveal the way how BRCC3 promotes carcinogenesis, we analyzed BRCC3-deficient bladder cancer cell lines by RNA-Seq, and the data showed that the NF-κB inflammatory pathway was notably downregulated when BRCC3 was knockout."
34604222
reach
"BRCC3 Promotes Tumorigenesis of Bladder Cancer by Activating the NF-κB Signaling Pathway Through Targeting TRAF2."
34604222
reach
"Here, we found that high expression of BRCC3 promoted tumorigenesis through targeting the TRAF2 protein."
34604222
Abraxas affects BRCA1, BRCC3, and UIMC1
| 6 1
BRCA1 binds BRCC3, UIMC1, and Abraxas. 6 / 6
| 6
reach
"BRCA1 encodes a protein forming the Rap80, Abraxas, Brca1, and Brcc36 complex in response to DNA damage XREF_BIBR."
29158785
reach
"UBC13 and RNF8 ubiquitin ligases control focus formation of the Rap80, Abraxas, Brca1, and Brcc36 complex in response to DNA damage."
24732096
reach
"It was proposed that the role of the BRCA1, Abraxas, RAP80, and BRCC36 complex is to limit DSB resection."
21666281
reach
"This activity and histone modification is required for the recruitment of other DDR proteins, specifically 53BP1 and the Rap80, Abraxas, Brca1, and Brcc36 complex to DSBs [167,168]."
19473885
reach
"Ubc13 and Rnf8 ubiquitin ligases control foci formation of the Rap80, Abraxas, Brca1, and Brcc36 complex in response to DNA damage."
18077395
reach
"Recruitment of the 53BP1 and Rif1 complex to DSBs promotes NHEJ repair and prevents the HR promoting BRCA1 and CtIP complex from binding to DSB sites (Chapman et al., 2013; Di Virgilio et al., 2013; F[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28943310
BRCA1 binds BRCA1, BRCC3, UIMC1, and Abraxas. 1 / 1
| 1
sparser
"After polyubiquitination of the chromatin, Brca1, a tumor suppressor protein that also possesses ubiquitin ligase activity, especially when it is complexed with Bard1, is recruited to the lesion together with Rap80, Abraxas, Brca1 and Brcc36, which form the BRCA1-A complex [ xref ]."
21037856
BRCC3 affects NFkappaB
| 2 4
BRCC3 activates NFkappaB. 6 / 6
| 2 4
reach
"BRCC3 binds to and synergizes with TRAF2 to activate NF-kappaB signaling."
34604222
reach
"Our results indicate that high BRCC3 expression activates NF-kappaB signaling by targeting TRAF2 for activation, which in turn facilitates tumorigenesis in bladder cancer."
34604222
eidos
"BRCC3 binds to and synergizes with TRAF2 to activate NF-kappaB signaling ."
34604222
eidos
"Our results indicate that high BRCC3 expression activates NF-kappaB signaling by targeting TRAF2 for activation , which in turn facilitates tumorigenesis in bladder cancer ."
34604222
reach
"BRCC3 Activated NF-kappaB Signaling Pathway via TRAF2."
34604222
reach
"BRCC3 Promotes Tumorigenesis of Bladder Cancer by Activating the NF-kappaB Signaling Pathway Through Targeting TRAF2."
34604222
BRCC3 affects Cell Survival
| 5
BRCC3 activates Cell Survival.
| 4
BRCC3 activates Cell Survival. 4 / 4
| 4
reach
"Knockdown of BRCC3 increased the cell survival fraction, attenuated DNA damage repair and resulted in G2/M cell cycle arrest in radioresistant NPC cells."
26024915
reach
"Our data showed that BRCC3 gene knockdown reduced the cell viability of TMZ treated U251 and A172 cells when compared to the relative TMZ treated mock cells."
25337721
reach
"Since BRCC 3 is one of most regulated molecules by miR-US25-1, we speculated that the cell viability reduction might be caused by the BRCC 3 blockage."
24895586
reach
"The inhibition of BRCC3 gene expression significantly reduces the cell viability and clonogenicity of U251 and A172 cells by TMZ treatment, indicating that BRCC3 can be treated as the target in order to enhance the sensitivity of glioma cells to TMZ."
25337721
BRCC3 inhibits Cell Survival.
| 1
reach
"Furthermore, BRCC3 interference inhibited the cell viability, invasion and migration abilities of HeLa and SiHa cells via regulation of EMT progression and expression levels of Snai family members."
30272359
BRCC3 affects CTNNB1
| 6
BRCC3 increases the amount of CTNNB1.
| 3
BRCC3 increases the amount of CTNNB1. 3 / 3
| 3
reach
"Depletion of BRCC3 promoted the activation of alkaline phosphatase and formation of calcified nodules in osteoblasts isolated from osteoporosis patients and up-regulated beta-catenin expression."
30834083
reach
"Consistently, depletion of BRCC3 increased the level of beta-catenin and promoted osteogenic differentiation, and inhibitor XAV939 inhibited the BRCC3 induced osteogenic differentiation."
30834083
reach
"Interestingly, we revealed that BRCC36 knockdown decreased beta-catenin expression in CRC cells, suggesting that binding between SHMT2 and BRCC36 may direct BRCC36 activity towards K63-Ub chains conjugated to beta-catenin in CRC cells."
33456583
BRCC3 decreases the amount of CTNNB1.
| 2
Modified BRCC3 decreases the amount of CTNNB1. 2 / 2
| 2
reach
"Additionally, BRCC3 overexpression significantly inhibited expressions of beta-catenin at both mRNA and protein levels (XREF_FIG)."
30834083
reach
"Additionally, the differentiation and beta-catenin expression were suppressed by BRCC3 overexpression."
30834083
BRCC3 activates CTNNB1.
| 1
BRCC3 activates CTNNB1. 1 / 1
| 1
reach
"BRCC3 siRNA promoted differentiation of osteoblasts and up-regulated beta-catenin After transfected with BRCC3 siRNA and cultured for 21 days, the cells were stained with ALP and ARS (XREF_FIG)."
30834083
BRCC3 affects BRCA2
4 | 1
BRCC3 binds BRCA2.
4 |
BRCA2 binds BRCC3. 4 / 5
4 |
biogrid
No evidence text available
14636569
biogrid
No evidence text available
14636569
biogrid
No evidence text available
14636569
biogrid
No evidence text available
17664283
BRCC3 ubiquitinates BRCA2.
| 1
BRCC3 leads to the ubiquitination of BRCA2. 1 / 1
| 1
reach
"Further, BRCC36 and BRCC45 enhance the E3 ubiquitin ligase activity of the multiprotein complex BRCA1, BARD1, and BRCA2 and ubiquitination of p53 in vitro."
16854521
BRCA1 affects BARD1
| 6
BRCA1 binds BRCC3, BARD1, and Abraxas. 3 / 3
| 3
reach
"Interactions of Abraxas, BACH1 and CtIP with the BRCT domain of BRCA1 are mutually exclusive, suggesting that the three proteins compete for the same binding site to form distinct BRCA1 containing complexes, of which only the Abraxas, BRCC36, BRCA1, and BARD1 complex is recruited to sites of DNA damage by RAP80 [XREF_BIBR]."
19473884
reach
"Receptor associated protein 80 (RAP80) plays a key role in recruiting the Abraxas, BRCC36, BRCA1, and BARD1 complex to DNA damage foci for DNA repair by possessing an Abraxas interacting region."
20357899
reach
"RAP80 has a key role in the recruitment of the Abraxas, BRCC36, BRCA1, and BARD1 complex to DNA-damage foci for DNA repair through specific recognition of Lys 63 linked polyubiquitinated proteins by its tandem ubiquitin interacting motifs (UIMs)."
19536136
BRCA1 binds BABAM2, BRCC3, and BARD1. 2 / 2
| 2
reach
"Furthermore, it has been demonstrated that in M-phase cells Rap80 exists in complex with the BRCA1, BARD1, BRCC36, and BRCC45 complex which is very abundant and its association is dependent on BRCC36 [XREF_BIBR]."
24832651
reach
"Fifth, through reconstitution of the BRCA1, BARD1, BRCC36, and BRE complex it demonstrates a role for BRCC36 and BRE in modulation of BRCA1 and BARD1 E3 ubiquitin ligase activity."
14636569
reach
"As discussed in Section 5.7, SUMOylation of BRCA1 is a prerequisite for BRCA1 's efficient in vitro and in vivo ubiquitylation activity [602,603], and autoubiquitylation [1038,1039] may promote this a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22743550
MiR-US25-1 affects BRCC3
| 5
MiR-US25-1 decreases the amount of BRCC3.
| 3
MiR-US25-1 decreases the amount of BRCC3. 3 / 3
| 3
reach
"In the present study, we have also confirmed the deregulation of BRCC 3 expression by miR-US25-1 and targeting the 5 ' UTR of BRCC 3."
24895586
reach
"And we have also confirmed the deregulation of BRCC 3 expression by miR-US25-1 by targeting the 5 ' UTR of it."
24895586
reach
"MiR-US25-1 Downregulates the Expression of BRCC 3 by Targeting the 5 ' UTR of BRCC 3."
24895586
MiR-US25-1 activates BRCC3.
| 2
MiR-US25-1 activates BRCC3. 2 / 2
| 2
reach
"Given the vital role of BRCC 3 in DNA damage repairing, we speculated that the targeting inhibition of BRCC 3 by miR-US25-1 may contribute to the aggravation of ox-LDL-promoted apoptosis of endothelial EAhy926 cells."
24895586
reach
"Given the vital role of BRCC 3 in DNA damage repairing [XREF_BIBR], we speculated that the targeting inhibition of BRCC 3 by miR-US25-1 may contribute to the cell viability reduction and the aggravation to ox-LDL-promoted apoptosis of endothelial EAhy926 cells."
24895586
CD276 affects BRCC3
| 5
CD276 increases the amount of BRCC3. 5 / 5
| 5
reach
"In 2016, Sun et al[62] reported in their in vitro study that overexpression of B7-H3 upregulates BRCA1/BRCA2-containing complex subunit 3 (BRCC3) expression and antagonizes the anticancer activity of 5-fluorouracil (5-FU)."
34457187
reach
"Altogether, results suggest that BRCC3 may play a role in B7-H3-induced 5-Fu resistance, such that B7-H3 upregulates BRCC3 expression, enhancing DNA repair in colorectal cancer cells."
27175567
reach
"Moreover, B7-H3 could upregulate BRCC3 or XRCC1 expression to antagonize DNA damage caused by 5-FU or L-OHP in CRC XREF_BIBR, XREF_BIBR."
32127943
reach
"In addition, a few other mechanisms may also underlie B7H3 mediated chemoresistance : (1) B7H3 induces oxaliplatin resistance by increasing the expression of XRCC1 via PI3K and AKT pathway; (2) B7H3 also enhances cell resistance to chemotherapy by increasing the expression of BRCC3, which antagonizes DNA damage caused by 5-FU; (3) or via the activation of the PI3K and AKT pathway."
30035102
reach
"B7-H3 upregulates BRCC3 expression, antagonizing DNA damage caused by 5-Fu."
27175567
BRCC3 activates signal transduction.
| 4
BRCC3 activates signal transduction. 4 / 4
| 4
reach
"BRCC3 Promotes Tumorigenesis of Bladder Cancer by Activating the NF-κB Signaling Pathway Through Targeting TRAF2."
34604222
reach
"BRCC3 Promotes Tumorigenesis of Bladder Cancer by Activating the NF-kappaB Signaling Pathway Through Targeting TRAF2."
34604222
reach
"We found that BRCC3 increased the activation NF-κB signaling pathway together with the upstream molecules TNFR and TRAF2 (Figure 5A)."
34604222
reach
"BRCC3 Activated NF-kappaB Signaling Pathway via TRAF2."
34604222
BRCC3 inhibits signal transduction.
| 1
reach
"Furthermore, TNFα and phospho-P65 was decreased while the level of IκBα was increased in the BRCC3 group, which confirmed that the abolition of BRCC3 inhibited the NF-κB signaling pathway (Figure 6E)."
34604222
BRCC3 affects SHMT2
2 | 3
SHMT2 binds BRCC3. 5 / 5
2 | 3
biogrid
No evidence text available
28514442
reach
"Interestingly, we revealed that BRCC36 knockdown decreased beta-catenin expression in CRC cells, suggesting that binding between SHMT2 and BRCC36 may direct BRCC36 activity towards K63-Ub chains conjugated to beta-catenin in CRC cells."
33456583
reach
"SHMT2 reportedly binds to BRCC36 and acts as an apparent competitive inhibitor for BRCC36 XREF_BIBR."
33456583
biogrid
No evidence text available
19615732
reach
"Given that SHMT2 and BRCC36 complexes work together to promote K-63 ubiquitin deubiquitination XREF_BIBR, we investigated whether BRCC36 is involved in beta-catenin deubiquitination."
33456583
BRCC3 affects IL1B
| 5
BRCC3 activates IL1B.
| 4
BRCC3 activates IL1B. 4 / 4
| 4
reach
"Besides, inhibition of BRCC3 blocked the increased secretion of IL-1beta."
31787240
reach
"Since transduction of wild-type BRCC3, but not of the inactive mutant BRCC3 H122Q, rescued caspase-1 cleavage and IL-1beta secretion inhibited by BRCC3 KD, we conclude that BRCC3 regulates NLRP3 throu[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23246432
reach
"Particularly, Benedicte et al. found that, knockdown of BRCC3 (a component of the BRISC complex) completely inhibited caspase-1 cleavage and IL-1beta secretion."
33627128
reach
"Furthermore, BRCC3 knockdown was shown to reduce the ATP induced secretion of mature IL-1beta by in macrophages."
33603747
BRCC3 inhibits IL1B.
| 1
BRCC3 inhibits IL1B. 1 / 1
| 1
reach
"Since transduction of wild-type BRCC3, but not of the inactive mutant BRCC3 H122Q, rescued caspase-1 cleavage and IL-1beta secretion inhibited by BRCC3 KD, we conclude that BRCC3 regulates NLRP3 throu[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23246432
BRCC3 affects DNA repair
| 3
BRCC3 activates DNA repair.
| 2
BRCC3 activates DNA repair. 2 / 4
| 2
reach
"Thus, the inhibition of BRCC3 expression may impair DNA repair mechanism in U251 and A172 cells, which can promotes sensitization of the two glioma cell lines to TMZ."
25337721
reach
"Altogether, results suggest that BRCC3 may play a role in B7-H3-induced 5-Fu resistance, such that B7-H3 upregulates BRCC3 expression, enhancing DNA repair in colorectal cancer cells."
27175567
BRCC3 inhibits DNA repair.
| 1
BRCC3 inhibits DNA repair. 1 / 1
| 1
reach
"In addition, the deficiency of BRCC3 gene expression reduced the levels of DNA repair associated genes (i.e. BRCA1, BRCA2, RAD51 and FANCD2) in TMZ treated U251 and A172 cells, when compared to those detected in TMZ treated mock cells."
25337721
BRCC3 affects DNA Damage
| 5
BRCC3 inhibits DNA Damage.
| 4
BRCC3 inhibits DNA Damage. 4 / 4
| 4
reach
"B7-H3 upregulates BRCC3 expression, antagonizing DNA damage caused by 5-Fu."
27175567
reach
"Knockdown of BRCC3 increased the cell survival fraction, attenuated DNA damage repair and resulted in G2/M cell cycle arrest in radioresistant NPC cells."
26024915
reach
"In addition, a few other mechanisms may also underlie B7H3 mediated chemoresistance : (1) B7H3 induces oxaliplatin resistance by increasing the expression of XRCC1 via PI3K and AKT pathway; (2) B7H3 also enhances cell resistance to chemotherapy by increasing the expression of BRCC3, which antagonizes DNA damage caused by 5-FU; (3) or via the activation of the PI3K and AKT pathway."
30035102
reach
"Moreover, B7-H3 could upregulate BRCC3 or XRCC1 expression to antagonize DNA damage caused by 5-FU or L-OHP in CRC XREF_BIBR, XREF_BIBR."
32127943
BRCC3 activates DNA Damage.
| 1
BRCC3 activates DNA Damage. 1 / 1
| 1
reach
"Given the fact that BRCC3 (BRCC36) is essential for the protection of breast cancer cells from ionizing radiation induced DNA damage [XREF_BIBR], a high level of BRCC3 could protect U251 and A172 cells from TMZ induced cytotoxicity."
25337721
BRCC3 affects CASP1
| 5
BRCC3 activates CASP1.
| 4
BRCC3 activates CASP1. 4 / 4
| 4
reach
"Since transduction of wild-type BRCC3, but not of the inactive mutant BRCC3 H122Q, rescued caspase-1 cleavage and IL-1beta secretion inhibited by BRCC3 KD, we conclude that BRCC3 regulates NLRP3 throu[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23246432
reach
"In addition, BRCC3 knockdown inhibited NLRP3 dependent, TLR independent cleaved caspase-1 secretion triggered by ATP in NG5 cells."
23246432
reach
"Particularly, Benedicte et al. found that, knockdown of BRCC3 (a component of the BRISC complex) completely inhibited caspase-1 cleavage and IL-1beta secretion."
33627128
reach
"Therefore, we conclude that BRCC3 might be involved in regulating deubiquitination of NLRP3.Consistent with an activator of NLRP3 activity, knockdown of BRCC3 inhibited mature IL-1beta and activated c[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23246432
BRCC3 inhibits CASP1.
| 1
BRCC3 inhibits CASP1. 1 / 1
| 1
reach
"Since transduction of wild-type BRCC3, but not of the inactive mutant BRCC3 H122Q, rescued caspase-1 cleavage and IL-1beta secretion inhibited by BRCC3 KD, we conclude that BRCC3 regulates NLRP3 throu[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23246432
BRCA2 affects BRCC3
4 |
BRCA2 binds BRCC3. 4 / 5
4 |
biogrid
No evidence text available
14636569
biogrid
No evidence text available
14636569
biogrid
No evidence text available
14636569
biogrid
No evidence text available
17664283
Hsa-miR-223-5p affects BRCC3
4 |
Hsa-miR-223-5p decreases the amount of BRCC3. 4 / 4
4 |
biopax:mirtarbase
No evidence text available
27418678
biopax:mirtarbase
No evidence text available
23824327
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-190a-3p affects BRCC3
4 |
Hsa-miR-190a-3p decreases the amount of BRCC3. 4 / 4
4 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
27418678
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
23824327
BRCC3 affects tat
| 4
BRCC3 activates tat.
| 3
BRCC3 activates tat. 3 / 3
| 3
reach
"Further analysis showed that knockdown of SHMT1,2 or BRCC36 reduced Tat protein stability without affecting mRNA levels (XREF_SUPPLEMENTARY, XREF_SUPPLEMENTARY)."
29791506
reach
"Moreover, point mutation of multiple lysines in Tat, or knockdown of BRCC36 or SHMT1,2, was sufficient to prevent destruction of Tat by JIB-04."
29791506
reach
"Taken together, these data strongly suggest that SHMT2 and BRCC36 and BRISC cooperate to rescue Tat from destruction through removal of K63Ub."
29791506
BRCC3 inhibits tat.
| 1
BRCC3 inhibits tat. 1 / 1
| 1
reach
"Taken together, these data suggested a model through which SHMT2 and BRCC36 act to reverse K63Ub of Tat, thereby preventing its destruction by autophagy (XREF_FIG)."
29791506
BRCC3 affects angiogenesis
| 4
BRCC3 activates angiogenesis.
| 3
BRCC3 activates angiogenesis. 3 / 3
| 3
reach
"Knockdown of this gene resulted in angiogenesis defects, which were also rescued by endothelium specific expression of BRCC3."
24517974
reach
"Here, we showed that most RNF213- and BRCC3 associated miRNAs were elevated in serum of MMD patients, repressed RNF213 and BRCC3 protein expression in HBMVEC, and modulated HBMVEC angiogenesis."
25093848
reach
"We also show that brcc3 morphant zebrafish display angiogenesis defects that are rescued by endothelium specific expression of brcc3."
21596366
BRCC3 inhibits angiogenesis.
| 1
BRCC3 inhibits angiogenesis. 1 / 1
| 1
reach
"Morpholino mediated knockdown of the BRCC3 ortholog in zebrafish led to defective angiogenesis that was rescued by endothelial specific expression of brcc3, strongly suggesting that this deubiquitinat[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21596366
BRCC3 affects TP53
3 | 1
BRCC3 binds TP53.
3 |
TP53 binds BRCC3. 3 / 3
3 |
biogrid
No evidence text available
14636569
biogrid
No evidence text available
14636569
biogrid
No evidence text available
14636569
BRCC3 ubiquitinates TP53.
| 1
BRCC3 leads to the ubiquitination of TP53. 1 / 1
| 1
reach
"Further, BRCC36 and BRCC45 enhance the E3 ubiquitin ligase activity of the multiprotein complex BRCA1, BARD1, and BRCA2 and ubiquitination of p53 in vitro."
16854521
BRCC3 affects STAT1
| 4
BRCC3 activates STAT1.
| 3
BRCC3 activates STAT1. 3 / 3
| 3
reach
"BRCC36 functions noncatalytically to promote antiviral response by maintaining STAT1 protein stability."
32673428
reach
"For example, BRCC36 functions noncatalytically by recruiting USP13 to counteract the SMURF1-mediated degradation of STAT1, and this effect enhances the stability of STAT1 and improves host antiviral efficiency (110)."
34707613
reach
"Supplementing BRCC36 enhanced antiviral response of allo-HSCT mice by maintaining STAT1 stability."
32673428
BRCC3 decreases the amount of STAT1.
| 1
BRCC3 decreases the amount of STAT1. 1 / 1
| 1
reach
"More specifically, BRCC36 deficiency leads to a rapid downregulation of STAT1 during viral infection, whereas complementation by BRCC36 can rescue the STAT1 expression levels and suppress virus infection (110)."
34707613
BRCC3 affects Interferon
| 4
BRCC3 deubiquitinates Interferon.
| 3
BRCC3 deubiquitinates Interferon. 3 / 3
| 3
reach
"Dr. Greenberg group from University of Pennsylvania showed that BRCC36 containing deubiquitinating complex BRISC which is also a sister protein complex of nuclear RAP80-BRCA1 complex, deubiquitinates type I interferon receptor (IFNAR1), resulting in its delayed lysosomal dependent degradation."
27211605
reach
"In the BRCC36 isopeptidase complex, BRCC36 promotes interferon dependent responses by deubiquitinating and stabilizing the type I interferon receptor XREF_BIBR."
27774986
reach
"The Abraxas complex (ARISC) functions in DNA repair and breast cancer suppression, while the BRCC36 isopeptidase complex (BRISC) promotes interferon dependent responses by deubiquitinating and stabilizing the type I interferon receptor, IFNAR1."
26344097
BRCC3 activates Interferon.
| 1
BRCC3 activates Interferon. 1 / 1
| 1
reach
"Unlike USP2A, the deubiquitinating enzymes BRCC36, USP13, and USP39 positively regulate IFN activities by attenuating the polyubiquitination level of STAT1, and this process is independent of IFN treatment, which suggests divergent functional roles of these DUBs under differential contexts.Additionally, ATXN3 does not affect IFN-I production during viral infection but positively regulates IFNAR1-mediated downstream signaling by targeting HDAC3 (108)."
34707613
reach
"Supporting this model, BRCC36 depletion increases DSB-associated conjugated ubiquitin and 53BP1 accumulation at DSB sites [189]."
21056014
reach
"BRCC36 downregulates DSB signaling by removing K63 linked polyubiquitin."
23845989
reach
"Supporting this model, BRCC36 depletion increases DSB associated conjugated ubiquitin and 53BP1 accumulation at DSB sites [189]."
21056014
reach
"Supporting this model, BRCC36 depletion increases DSB associated conjugated ubiquitin and 53BP1 accumulation at DSB sites XREF_BIBR."
21056014
BABAM2 affects BABAM1
| 4
BABAM2 binds BRCC3 and BABAM1. 4 / 4
| 4
reach
"Our LC-MS analysis and immunoprecipitation data showed that tankyrase was associated with the BRE-BRCC36-MERIT40 complex (or the BRCA1-A complex) via MERIT40."
30533199
reach
"In this study, we performed liquid chromatography-mass spectrometry (LC-MS) analysis and identified the MERIT40-BRE-BRCC36 complex as tankyrase-binding proteins."
30533199
reach
"To explore the novel functions of tankyrase, we performed liquid chromatography-mass spectrometry analysis and identified the BRE, BRCC36, and MERIT40 complex, a regulator of homologous recombination, as tankyrase binding proteins."
30533199
reach
"To explore the novel functions of tankyrase, we performed liquid chromatography-mass spectrometry analysis and identified the BRE-BRCC36-MERIT40 complex, a regulator of homologous recombination, as tankyrase-binding proteins."
30533199
Hsa-miR-6867-5p affects BRCC3
3 |
Hsa-miR-6867-5p decreases the amount of BRCC3. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
27418678
Hsa-miR-574-5p affects BRCC3
3 |
Hsa-miR-574-5p decreases the amount of BRCC3. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
27418678
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-511-3p affects BRCC3
3 |
Hsa-miR-511-3p decreases the amount of BRCC3. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
27418678
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-5011-5p affects BRCC3
3 |
Hsa-miR-5011-5p decreases the amount of BRCC3. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
23824327
biopax:mirtarbase
No evidence text available
27418678
Hsa-miR-3121-5p affects BRCC3
3 |
Hsa-miR-3121-5p decreases the amount of BRCC3. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
23446348
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-1277-5p affects BRCC3
3 |
Hsa-miR-1277-5p decreases the amount of BRCC3. 3 / 3
3 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
27418678
biopax:mirtarbase
No evidence text available
23824327
UBC affects BRCC3
3 |
UBC binds BRCC3. 3 / 3
3 |
biogrid
No evidence text available
28190767
biogrid
No evidence text available
19261749
biogrid
No evidence text available
19202061
TP53 affects BRCC3
3 |
TP53 binds BRCC3. 3 / 3
3 |
biogrid
No evidence text available
14636569
biogrid
No evidence text available
14636569
biogrid
No evidence text available
14636569
RAD51 affects BRCC3
3 |
BRCC3 binds RAD51. 3 / 3
3 |
biogrid
No evidence text available
14636569
biogrid
No evidence text available
14636569
biogrid
No evidence text available
14636569
NUMA1 affects BRCC3
2 |
BRCC3 binds NUMA1. 2 / 3
2 |
biogrid
No evidence text available
26195665
biogrid
No evidence text available
26195665
BRCC3
1 | 1
BRCC3 binds.
1 |
BRCC3 binds BRCC3. 1 / 2
1 |
biogrid
No evidence text available
21282113
BRCC3 translocates.
| 1
BRCC3 translocates. 1 / 1
| 1
reach
"However, we can not exclude that additional unknown mechanisms are involved in BRCC3 recruitment to telomeres."
23389450
BRCC3 affects temozolomide
| 3
BRCC3 activates temozolomide. 3 / 3
| 3
reach
"Our data showed that BRCC3 gene knockdown reduced the cell viability of TMZ treated U251 and A172 cells when compared to the relative TMZ treated mock cells."
25337721
reach
"BRCC3 gene knockdown through lentivirus mediated gene knockdown approach not only significantly reduced the clonogenic and migratory abilities of U251 and A172 cells, but also enhanced their sensitization to TMZ."
25337721
reach
"Accordingly, we examined if the depletion of BRCC3 promotes TMZ induced cytotoxicity in U251 and A172 cells."
25337721
BRCC3 affects interferon receptor
| 3
BRCC3 deubiquitinates interferon receptor. 3 / 3
| 3
reach
"The Abraxas complex (ARISC) functions in DNA repair and breast cancer suppression, while the BRCC36 isopeptidase complex (BRISC) promotes interferon dependent responses by deubiquitinating and stabilizing the type I interferon receptor, IFNAR1."
26344097
reach
"In the BRCC36 isopeptidase complex, BRCC36 promotes interferon dependent responses by deubiquitinating and stabilizing the type I interferon receptor XREF_BIBR."
27774986
reach
"Dr. Greenberg group from University of Pennsylvania showed that BRCC36 containing deubiquitinating complex BRISC which is also a sister protein complex of nuclear RAP80-BRCA1 complex, deubiquitinates type I interferon receptor (IFNAR1), resulting in its delayed lysosomal dependent degradation."
27211605
BRCC3 affects UBC
3 |
UBC binds BRCC3. 3 / 3
3 |
biogrid
No evidence text available
28190767
biogrid
No evidence text available
19261749
biogrid
No evidence text available
19202061
BRCC3 affects TP53BP1
| 3
BRCC3 activates TP53BP1.
| 2
BRCC3 activates TP53BP1. 2 / 2
| 2
reach
"XREF_BIBR Importantly co-depletion of POH1 and BRCC36 did not elicit 53BP1 foci larger than POH1 depletion alone, suggesting these DUBs act in the same mechanistic pathway to restrict 53BP1 assemblies."
23075493
reach
"Co-depletion of POH1 and RAP80, BRCC36 or ABRAXAS allows establishment of the 53BP1 and ubiquitin chain-devoid core."
24013561
BRCC3 decreases the amount of TP53BP1.
| 1
BRCC3 decreases the amount of TP53BP1. 1 / 1
| 1
reach
"This complex also contains K63-Ub-specific DUB, BRCC36, able to hydrolyse K63-chains and restrict the amount of 53BP1 at damaged chromatin."
23075493
BRCC3 affects RNF8
| 3
BRCC3 inhibits RNF8.
| 2
BRCC3 inhibits RNF8. 2 / 2
| 2
reach
"In this complex, BRCC36 works together with the proteins NBA1, ABRO1, ABRA1 and BRCC45 in cleaving K63 linked ubiquitin chains and therefore seems to antagonize the ubiquitinating function of UBC13, RNF8 and RNF168."
20817926
reach
"BRCC36 and POH1 antagonize the actions of RNF8 and RNF168, hydrolyzing the K63 linkages that promote 53BP1 recruitment."
23554604
BRCC3 deubiquitinates RNF8.
| 1
BRCC3 deubiquitinates RNF8. 1 / 1
| 1
reach
"This suggests that BRCC36 normally deubiquitylates the substrate of RNF8 and UBC13 at DSBs."
20029420
BRCC3 affects RAD51
3 |
BRCC3 binds RAD51. 3 / 3
3 |
biogrid
No evidence text available
14636569
biogrid
No evidence text available
14636569
biogrid
No evidence text available
14636569
BRCC3 affects PYCARD
| 2 1
BRCC3 phosphorylates PYCARD.
| 1
BRCC3 leads to the phosphorylation of PYCARD. 1 / 1
| 1
reach
"Priming requires IRAK1 activation and proteasome dependent ERK activation (with downstream MEK1/2 activation), and it involves post-translational modifications including : (i) BRCC3 mediated NLRP3 deubiquitination, (ii) LUBAC mediated ASC ubiquitination, and (iii) SYK- and JNK dependent ASC phosphorylation."
25879282
BRCC3 deubiquitinates PYCARD.
| 1
BRCC3 leads to the deubiquitination of PYCARD. 1 / 1
| 1
reach
"Priming requires IRAK1 activation and proteasome dependent ERK activation (with downstream MEK1/2 activation), and it involves post-translational modifications including : (i) BRCC3 mediated NLRP3 deubiquitination, (ii) LUBAC mediated ASC ubiquitination, and (iii) SYK- and JNK dependent ASC phosphorylation."
25879282
BRCC3 binds PYCARD.
| 1
PYCARD binds BRCC3. 1 / 1
| 1
isi
"Mechanism study revealed that celastrol could interdict K63 deubiquitination of NLRP3, which may concern interaction of celastrol and BRCA1/BRCA2-containing complex subunit 3 (BRCC3), and thereby prohibited the formation of NLRP3, ASC and pro-caspase-1 complex to block the generation of mature IL-1beta."
33130474
BRCC3 activates Neoplasm Invasiveness.
| 2
BRCC3 activates Neoplasm Invasiveness. 2 / 2
| 2
reach
"The cell migration and invasion of U251 and A172 cells are also impaired by BRCC3 knockdown."
25337721
reach
"The cell invasion of the two cell lines was also diminished by the inhibition of BRCC3 expression."
25337721
reach
"Furthermore, BRCC3 interference inhibited the cell viability, invasion and migration abilities of HeLa and SiHa cells via regulation of EMT progression and expression levels of Snai family members."
30272359
BRCC3 affects NACHT
| 3
BRCC3 leads to the deubiquitination of NACHT on K64. 1 / 1
| 1
reach
"Recently, Py and colleagues demonstrated that BRCC3, a JAMM domain containing zinc metalloprotease DUB, promotes NLRP3 inflammasome activation by deubiquitinating the mixed K64 and K48 ubiquitin chains on both the NACHT and LRR domains of NLRP3 [XREF_BIBR]."
25698849
BRCC3 leads to the deubiquitination of NACHT. 1 / 1
| 1
reach
"Recently, Py and colleagues demonstrated that BRCC3, a JAMM domain containing zinc metalloprotease DUB, promotes NLRP3 inflammasome activation by deubiquitinating the mixed K64 and K48 ubiquitin chains on both the NACHT and LRR domains of NLRP3 [XREF_BIBR]."
25698849
BRCC3 leads to the deubiquitination of NACHT on K48. 1 / 1
| 1
reach
"Recently, Py and colleagues demonstrated that BRCC3, a JAMM domain containing zinc metalloprotease DUB, promotes NLRP3 inflammasome activation by deubiquitinating the mixed K64 and K48 ubiquitin chains on both the NACHT and LRR domains of NLRP3 [XREF_BIBR]."
25698849
BRCC3 affects FANCG
2 1 |
BRCC3 binds FANCG.
2 |
BRCC3 binds FANCG. 2 / 2
2 |
biogrid
No evidence text available
25132264
biogrid
No evidence text available
25132264
BRCC3 deubiquitinates FANCG.
1 |
BRCC3 deubiquitinates FANCG. 1 / 1
1 |
ubibrowser
"?we demonstrated that K63Ub-modified FANCG was deubiquitinated by BRCC36 complex in vitro and in vivo"
25132264
BRCC3 affects E3_Ub_ligase
| 3
BRCC3 activates E3_Ub_ligase. 2 / 2
| 2
reach
"But beside the canonical role of deubiquitinating enzymes in antagonizing ubiquitin ligase activity, BRCC36 also enhances BRCA1 and BARD1 E3 ubiquitin ligase activity."
20817926
reach
"These results indicate that the two new subunits, BRCC36 and BRE, potentiate the E3 ligase activity of BRCA1 and BARD1."
14636569
BRCC3 bound to BABAM2 activates E3_Ub_ligase. 1 / 1
| 1
reach
"The interaction between BRE and BRCC36 has been reported to enhance the E3 ligase activity of BRCA1-BARD1 in a BRCC complex XREF_BIBR."
27001068
BRCC3 affects BRCC3
| 2
BRCC3 decreases the amount of BRCC3. 2 / 3
| 2
reach
"Consistently, BRCC3 siRNA treatment of MDA-MB 231 cells caused decreased expression of BRCC3 and p-ERK."
17143545
reach
"Here, we showed that most RNF213- and BRCC3 associated miRNAs were elevated in serum of MMD patients, repressed RNF213 and BRCC3 protein expression in HBMVEC, and modulated HBMVEC angiogenesis."
25093848
BRCC3 affects ABRAXAS
| 3
BRCC3 binds UIMC1 and ABRAXAS. 2 / 2
| 2
reach
"The requirement for POH1 for generation of a devoid core can be relieved by depletion of any member of the RAP80, BRCC36, and ABRAXAS complex."
24013561
reach
"MERIT40 knockdown unravel the negative effect on the RAP80, BRCC36 and ABRAXAS complex irrespective of BRCA1."
24667604
BRCC3 binds ABRAXAS. 1 / 1
| 1
reach
"BRCA1 is found in several different complexes that have opposite roles in DNA end resection : MRN/CtIP/BRCA1 favors resection whereas the BRCA1 and RAP80 / BRCC36 and ABRAXAS complex inhibits resection and promotes C-NHEJ."
27308383
BARD1 affects Abraxas
| 3
BRCA1 binds BRCC3, BARD1, and Abraxas. 3 / 3
| 3
reach
"Interactions of Abraxas, BACH1 and CtIP with the BRCT domain of BRCA1 are mutually exclusive, suggesting that the three proteins compete for the same binding site to form distinct BRCA1 containing complexes, of which only the Abraxas, BRCC36, BRCA1, and BARD1 complex is recruited to sites of DNA damage by RAP80 [XREF_BIBR]."
19473884
reach
"Receptor associated protein 80 (RAP80) plays a key role in recruiting the Abraxas, BRCC36, BRCA1, and BARD1 complex to DNA damage foci for DNA repair by possessing an Abraxas interacting region."
20357899
reach
"RAP80 has a key role in the recruitment of the Abraxas, BRCC36, BRCA1, and BARD1 complex to DNA-damage foci for DNA repair through specific recognition of Lys 63 linked polyubiquitinated proteins by its tandem ubiquitin interacting motifs (UIMs)."
19536136
ABRAXAS affects BRCC3
| 3
BRCC3 binds UIMC1 and ABRAXAS. 2 / 2
| 2
reach
"The requirement for POH1 for generation of a devoid core can be relieved by depletion of any member of the RAP80, BRCC36, and ABRAXAS complex."
24013561
reach
"MERIT40 knockdown unravel the negative effect on the RAP80, BRCC36 and ABRAXAS complex irrespective of BRCA1."
24667604
BRCC3 binds ABRAXAS. 1 / 1
| 1
reach
"BRCA1 is found in several different complexes that have opposite roles in DNA end resection : MRN/CtIP/BRCA1 favors resection whereas the BRCA1 and RAP80 / BRCC36 and ABRAXAS complex inhibits resection and promotes C-NHEJ."
27308383
Hsa-miR-567 affects BRCC3
2 |
Hsa-miR-567 decreases the amount of BRCC3. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
23446348
Hsa-miR-297 affects BRCC3
2 |
Hsa-miR-297 decreases the amount of BRCC3. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
23446348
Dibutyl phthalate affects BRCC3
2 |
Dibutyl phthalate decreases the amount of BRCC3. 2 / 2
2 |
ctd
No evidence text available
21266533
ctd
No evidence text available
17361019
Bisphenol A affects BRCC3
2 |
Bisphenol A increases the amount of BRCC3.
1 |
Bisphenol A increases the amount of BRCC3. 1 / 1
1 |
ctd
No evidence text available
22576693
Bisphenol A decreases the amount of BRCC3.
1 |
Bisphenol A decreases the amount of BRCC3. 1 / 1
1 |
ctd
No evidence text available
30816183
Benzo[a]pyrene affects BRCC3
2 |
Benzo[a]pyrene increases the amount of BRCC3.
1 |
Benzo[a]pyrene increases the amount of BRCC3. 1 / 1
1 |
ctd
No evidence text available
22228805
Benzo[a]pyrene decreases the amount of BRCC3.
1 |
Benzo[a]pyrene decreases the amount of BRCC3. 1 / 1
1 |
ctd
No evidence text available
19770486
Aflatoxin B1 affects BRCC3
2 |
Aflatoxin B1 increases the amount of BRCC3.
1 |
Aflatoxin B1 increases the amount of BRCC3. 1 / 1
1 |
ctd
No evidence text available
19770486
Aflatoxin B1 demethylates BRCC3.
1 |
Aflatoxin B1 demethylates BRCC3. 1 / 1
1 |
ctd
No evidence text available
27153756
WWP2 affects BRCC3
1 | 1
WWP2 ubiquitinates BRCC3.
| 1
WWP2 leads to the ubiquitination of BRCC3. 1 / 1
| 1
reach
"The HECT-type E3 ubiquitin ligase WWP2 modulates BRCC3 ubiquitination and degradation."
33107021
WWP2 binds BRCC3.
1 |
WWP2 binds BRCC3. 1 / 1
1 |
biogrid
No evidence text available
25071155
USP14 affects TRIM14
| 2
USP14 binds TRIM14 and BRCC3. 2 / 2
| 2
reach
"The TRIM14-USP14-BRCC3 complex epigenetically regulates inflammation through inhibiting OPTN-mediated autophagic degradation of KDM4D."
35311471
reach
"The TRIM14-USP14-BRCC3 complex epigenetically regulates inflammation through inhibiting OPTN-mediated autophagic degradation of KDM4D."
35311471
UIMC1 affects ABRAXAS
| 2
BRCC3 binds UIMC1 and ABRAXAS. 2 / 2
| 2
reach
"The requirement for POH1 for generation of a devoid core can be relieved by depletion of any member of the RAP80, BRCC36, and ABRAXAS complex."
24013561
reach
"MERIT40 knockdown unravel the negative effect on the RAP80, BRCC36 and ABRAXAS complex irrespective of BRCA1."
24667604
TRIM14 affects USP14
| 2
USP14 binds TRIM14 and BRCC3. 2 / 2
| 2
reach
"The TRIM14-USP14-BRCC3 complex epigenetically regulates inflammation through inhibiting OPTN-mediated autophagic degradation of KDM4D."
35311471
reach
"The TRIM14-USP14-BRCC3 complex epigenetically regulates inflammation through inhibiting OPTN-mediated autophagic degradation of KDM4D."
35311471
TRAF2 affects BRCC3
| 2
TRAF2 binds BRCC3. 2 / 2
| 2
reach
"We identified BRCC3 bound to TRAF2 to activate NF-κB signaling."
34604222
reach
"Through co-transfecting of the node protein of the NF-κB pathway, we reported that BRCC3 maximizes the potential of TRAF2 to activate the NF-κB pathway, and further exploration showed that BRCC3 binds to TRAF2."
34604222
TMPO-AS1 affects BRCC3
| 1 1
TMPO-AS1 increases the amount of BRCC3. 1 / 1
| 1
reach
"Furthermore, it was found that TMPO-AS1 acted as a ceRNA for miR-126-5p to upregulate BRCC3 expression."
33295056
TMPO-AS1 increases the amount of BRCC3. 1 / 1
| 1
isi
"Furthermore, it was found that TMPO-AS1 acted as a ceRNA for miR-126-5p to upregulate BRCC3 expression."
33295056
TCHH affects BRCC3
| 2
TCHH inhibits BRCC3.
| 1
TCHH inhibits BRCC3. 1 / 1
| 1
reach
"Thiolutin also inhibits the JAMM metalloproteases Csn5, the deneddylase of the COP9 signalosome, Associated-molecule-with-the-SH3-Domain-of-STAM (AMSH), which regulates ubiquitin dependent sorting of cell-surface receptors, and Brcc36, a K63 specific deubiquitnase of BRCC36 containing isopeptidase complex (BRISC) and BRCA1, BRCA2, and containing complex (BRCC)."
28459440
TCHH activates BRCC3.
| 1
TCHH activates BRCC3. 1 / 1
| 1
reach
"We showed here that the reduced forms of THL and other DTPs act as Zn 2+ chelators to inhibit the JAMM metalloproteases Rpn11, Csn5 AMSH, and Brcc36."
28459440
SYVN1 affects BRCC3
| 2
SYVN1 inhibits BRCC3.
| 1
SYVN1 inhibits BRCC3. 1 / 1
| 1
reach
"SYVN1-mediated BRCC3 down-regulation promoted NLRP3 ubiquitination and reduced pro-inflammatory cytokine secretion."
34874278
SYVN1 deubiquitinates BRCC3.
| 1
SYVN1 leads to the deubiquitination of BRCC3. 1 / 1
| 1
reach
"Overexpressing SYVN1 promoted the ubiquitination and degradation of BRCC3 and reduced the secretion of pro-inflammatory cytokines in HG-induced Müller cells."
34874278
SUMO2 affects BRCC3
2 |
SUMO2 binds BRCC3. 2 / 2
2 |
biogrid
No evidence text available
22689573
biogrid
No evidence text available
23211528
SNAPC5 affects BRCC3
1 1 |
SNAPC5 binds BRCC3. 2 / 2
1 1 |
hprd
No evidence text available
16189514
biogrid
No evidence text available
16189514
Plant Extracts affects BRCC3
2 |
Plant Extracts increases the amount of BRCC3.
1 |
Plant Extracts increases the amount of BRCC3. 1 / 1
1 |
ctd
No evidence text available
23557933
Plant Extracts decreases the amount of BRCC3.
1 |
Plant Extracts decreases the amount of BRCC3. 1 / 1
1 |
ctd
No evidence text available
15465739
Phosphatase affects BRCC3
| 2
Phosphatase dephosphorylates BRCC3 on tyrosine. 1 / 1
| 1
reach
"Dephosphorylation of Y859p by protein tyrosine phosphatase non receptor 22 (PTPN22) 45 and BRCC3 deubiquitination of LRR domain 46 are also missing in miniNLRP3."
30518920
Phosphatase dephosphorylates BRCC3. 1 / 1
| 1
reach
"Dephosphorylation of Y859p by protein tyrosine phosphatase non receptor 22 (PTPN22) 45 and BRCC3 deubiquitination of LRR domain 46 are also missing in miniNLRP3."
30518920
PWWP2B affects BRCC3
| 2
PWWP2B binds BRCC3.
| 1
BRCC3 binds PWWP2B. 1 / 1
| 1
reach
"BRCC3 interacts and stabilizes HDAC1 or PWWP2B individually (Figure S7c,d, Supporting Information), and the presence of PWWP2B could further augment the BRCC3 interacting with and stabilizing HDAC1 protein (Figure S7c,d, Supporting Information, see the last lane in each Figure)."
34180153
PWWP2B activates BRCC3.
| 1
PWWP2B activates BRCC3. 1 / 1
| 1
reach
"BRCC3 interacts and stabilizes HDAC1 or PWWP2B individually (Figure S7c,d, Supporting Information), and the presence of PWWP2B could further augment the BRCC3 interacting with and stabilizing HDAC1 protein (Figure S7c,d, Supporting Information, see the last lane in each Figure)."
34180153
K63-Ub 2 affects BRCC3
| 2
BRCC3 binds K63-Ub 2. 2 / 2
| 2
reach
"Thus, it is likely that BRCC36 and AMSH-LP bind K63-Ub 2 similarly."
28587922
reach
"Thus, it is likely that BRCC36 and AMSH-LP bind K63-Ub 2 similarly.Comparison of the BRCC36 homodimer and heterodimer structures suggests an explanation for the loss of catalytic activity in the homod[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28587922
ICP0 affects BRCC3
| 2
ICP0 inhibits BRCC3. 2 / 2
| 2
reach
"HSV-1-encoded ICP0 degrades the host deubiquitinase BRCC36 to antagonize interferon antiviral response."
33857816
reach
"HSV is particularly effective in this antagonism, with HSV ICP0 promoting degradation of the host deubiquitinase BRCC36, resulting in downregulation of IFNAR1 in a variety of human and mouse cell lines in vitro [140]."
34629295
HDAC1 affects BRCC3
1 | 1
BRCC3 binds HDAC1. 2 / 2
1 | 1
biogrid
No evidence text available
22863883
reach
"BRCC3 interacts and stabilizes HDAC1 or PWWP2B individually (Figure S7c,d, Supporting Information), and the presence of PWWP2B could further augment the BRCC3 interacting with and stabilizing HDAC1 protein (Figure S7c,d, Supporting Information, see the last lane in each Figure)."
34180153
GABPB2 affects BRCC3
2 |
GABPB2 decreases the amount of BRCC3. 2 / 2
2 |
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
GABPA affects BRCC3
2 |
GABPA decreases the amount of BRCC3. 2 / 2
2 |
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
FANCG affects BRCC3
2 |
BRCC3 binds FANCG. 2 / 2
2 |
biogrid
No evidence text available
25132264
biogrid
No evidence text available
25132264
DEF6 affects BRCC3
2 |
BRCC3 binds DEF6. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
BRISC deubiquitase affects BRCC3
| 2
BRCC3 binds BRISC deubiquitase. 2 / 2
| 2
reach
"Although Sagnier et al. [XREF_BIBR] suggested that autophagy selectively degrades HIV-1 Tat through a ubiquitin independent interaction with SQSTM1, Xu et al. demonstrated that HIV-1 Tat undergoes K63 polyubiquitination, a mark recognised by SQSTM1 and the NBR1 autophagy cargo receptor [XREF_BIBR, XREF_BIBR, XREF_BIBR], complexes with the CMA specific chaperone HSPA8 and is subjected to K63Ub selective autophagy mediated by serine hydroxymethyltransferase (SHMT) 1, SHMT2 and the BRCC36 and BRISC deubiquitase complex [XREF_BIBR]."
| PMC
reach
"Here we show that SHMT1,2 and the BRCC36 and BRISC deubiquitase complex are novel and selective regulators of Tat K63, but not K48, ubiquitylation, and its degradation through selective autophagy in T cells."
29791506
reach
"Although the suppressive role of BRCC36 in RNF8 dependent DDR suggests that BRCC36 promotes HR, the depletion of BRCC36 increases HR efficiency [XREF_BIBR]."
26983989
reach
"Interestingly, the depletion of BRCC36 increases HR, which goes against the suppressive role of BRCC36 in RNF8 dependent DDR that should suggest that BRCC36 promotes HR."
30831436
BRCC3 affects cell growth
| 1
BRCC3 inhibits cell growth. 1 / 2
| 1
reach
"Moreover, the depletion of BRCC3 gene expression decreases the cell growth and clonogenic ability of U251 and A172 cells."
25337721
BRCC3 affects cell death
| 2
BRCC3 inhibits cell death.
| 1
BRCC3 inhibits cell death. 1 / 1
| 1
reach
"Moreover, BRCC3 gene knockdown promoted the cell death of U251 and A172 cells in response to BCNU (XREF_SUPPLEMENTARY)."
25337721
BRCC3 activates cell death.
| 1
BRCC3 activates cell death. 1 / 1
| 1
reach
"Furthermore, exogenous BRCC3 expression was associated with a delay in etoposide induced cell death and an increase in cell proliferation."
17143545
BRCC3 affects USP7
1 | 1
BRCC3 deubiquitinates USP7.
| 1
BRCC3 deubiquitinates USP7. 1 / 1
| 1
reach
"To identify the DUB associated with NALP7, we over-expressed plasmids expressing several candidate DUBs including BRCC3, which deubiquitinates NALP3, COPS5, STAMBPL1, USP7 and the endosome associated DUBs, STAMBP and USP8."
28492230
BRCC3 binds USP7.
1 |
USP7 binds BRCC3. 1 / 1
1 |
biogrid
No evidence text available
19615732
BRCC3 affects USP14
| 2
USP14 binds TRIM14 and BRCC3. 2 / 2
| 2
reach
"The TRIM14-USP14-BRCC3 complex epigenetically regulates inflammation through inhibiting OPTN-mediated autophagic degradation of KDM4D."
35311471
reach
"The TRIM14-USP14-BRCC3 complex epigenetically regulates inflammation through inhibiting OPTN-mediated autophagic degradation of KDM4D."
35311471
BRCC3 affects UBE2N
| 2
BRCC3 inhibits UBE2N.
| 1
BRCC3 inhibits UBE2N. 1 / 1
| 1
reach
"In this complex, BRCC36 works together with the proteins NBA1, ABRO1, ABRA1 and BRCC45 in cleaving K63 linked ubiquitin chains and therefore seems to antagonize the ubiquitinating function of UBC13, RNF8 and RNF168."
20817926
BRCC3 deubiquitinates UBE2N.
| 1
BRCC3 deubiquitinates UBE2N. 1 / 1
| 1
reach
"This suggests that BRCC36 normally deubiquitylates the substrate of RNF8 and UBC13 at DSBs."
20029420
BRCC3 affects TRIM14, and USP14
| 2
USP14 binds TRIM14 and BRCC3. 2 / 2
| 2
reach
"The TRIM14-USP14-BRCC3 complex epigenetically regulates inflammation through inhibiting OPTN-mediated autophagic degradation of KDM4D."
35311471
reach
"The TRIM14-USP14-BRCC3 complex epigenetically regulates inflammation through inhibiting OPTN-mediated autophagic degradation of KDM4D."
35311471
BRCC3 affects TNKS
1 | 1
BRCC3 ubiquitinates TNKS.
| 1
BRCC3 ubiquitinates TNKS. 1 / 1
| 1
reach
"Cell cycle regulated ubiquitination of tankyrase 1 by RNF8 and ABRO1 and BRCC36 controls the timing of sister telomere resolution."
27993934
BRCC3 deubiquitinates TNKS.
1 |
BRCC3 deubiquitinates TNKS. 1 / 1
1 |
ubibrowser
"Cell cycle-regulated ubiquitination of tankyrase 1 by RNF8 and ABRO1/BRCC36 controls the timing of sister telomere resolution"
27993934
BRCC3 affects TNF
| 2
BRCC3 inhibits TNF.
| 1
BRCC3 inhibits TNF. 1 / 1
| 1
reach
"In addition, Real-time PCR analyses indicated that the ablation of BRCC3 reduced the expression of the NF-κB signaling down-stream genes including cIAP2, TNFα, and ICAM (Figure 4F)."
34604222
BRCC3 activates TNF.
| 1
BRCC3 activates TNF. 1 / 1
| 1
reach
"We found that the downregulation of BRCC3 led to a specific and strong blockage of IL-1beta release triggered by ATP, while it had no effect on the NLRP3 independent TNF-alpha and IL-6 secretion induc[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23246432
BRCC3 affects SYK
| 2
BRCC3 phosphorylates SYK.
| 1
BRCC3 leads to the phosphorylation of SYK. 1 / 1
| 1
reach
"Priming requires IRAK1 activation and proteasome dependent ERK activation (with downstream MEK1/2 activation), and it involves post-translational modifications including : (i) BRCC3 mediated NLRP3 deubiquitination, (ii) LUBAC mediated ASC ubiquitination, and (iii) SYK- and JNK dependent ASC phosphorylation."
25879282
BRCC3 deubiquitinates SYK.
| 1
BRCC3 leads to the deubiquitination of SYK. 1 / 1
| 1
reach
"Priming requires IRAK1 activation and proteasome dependent ERK activation (with downstream MEK1/2 activation), and it involves post-translational modifications including : (i) BRCC3 mediated NLRP3 deubiquitination, (ii) LUBAC mediated ASC ubiquitination, and (iii) SYK- and JNK dependent ASC phosphorylation."
25879282
BRCC3 affects SUMO2
2 |
SUMO2 binds BRCC3. 2 / 2
2 |
biogrid
No evidence text available
22689573
biogrid
No evidence text available
23211528
BRCC3 affects STAMBPL1
| 2
BRCC3 deubiquitinates STAMBPL1.
| 1
BRCC3 deubiquitinates STAMBPL1. 1 / 1
| 1
reach
"To identify the DUB associated with NALP7, we over-expressed plasmids expressing several candidate DUBs including BRCC3, which deubiquitinates NALP3, COPS5, STAMBPL1, USP7 and the endosome associated DUBs, STAMBP and USP8."
28492230
BRCC3 binds STAMBPL1.
| 1
STAMBPL1 binds BRCC3. 1 / 1
| 1
reach
"Thus, it is likely that BRCC36 and AMSH-LP bind K63-Ub 2 similarly.Comparison of the BRCC36 homodimer and heterodimer structures suggests an explanation for the loss of catalytic activity in the homod[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28587922
BRCC3 affects SNAPC5
1 1 |
SNAPC5 binds BRCC3. 2 / 2
1 1 |
hprd
No evidence text available
16189514
biogrid
No evidence text available
16189514
BRCC3 affects RNF168
| 2
BRCC3 inhibits RNF168. 2 / 2
| 2
reach
"In this complex, BRCC36 works together with the proteins NBA1, ABRO1, ABRA1 and BRCC45 in cleaving K63 linked ubiquitin chains and therefore seems to antagonize the ubiquitinating function of UBC13, RNF8 and RNF168."
20817926
reach
"BRCC36 and POH1 antagonize the actions of RNF8 and RNF168, hydrolyzing the K63 linkages that promote 53BP1 recruitment."
23554604
BRCC3 affects K63Ub
| 2
BRCC3 bound to BRISC deubiquitase activates K63Ub. 1 / 1
| 1
reach
"Although Sagnier et al. [XREF_BIBR] suggested that autophagy selectively degrades HIV-1 Tat through a ubiquitin independent interaction with SQSTM1, Xu et al. demonstrated that HIV-1 Tat undergoes K63 polyubiquitination, a mark recognised by SQSTM1 and the NBR1 autophagy cargo receptor [XREF_BIBR, XREF_BIBR, XREF_BIBR], complexes with the CMA specific chaperone HSPA8 and is subjected to K63Ub selective autophagy mediated by serine hydroxymethyltransferase (SHMT) 1, SHMT2 and the BRCC36 and BRISC deubiquitase complex [XREF_BIBR]."
| PMC
BRCC3 activates K63Ub. 1 / 1
| 1
reach
"Importantly, depletion of either BRCC36 or SHMT1 in HeLa cells also selectively increased K63Ub, but not K48Ub, of the FLAG-Tat protein (XREF_FIG)."
29791506
BRCC3 affects K63-Ub 2
| 2
BRCC3 binds K63-Ub 2. 2 / 2
| 2
reach
"Thus, it is likely that BRCC36 and AMSH-LP bind K63-Ub 2 similarly."
28587922
reach
"Thus, it is likely that BRCC36 and AMSH-LP bind K63-Ub 2 similarly.Comparison of the BRCC36 homodimer and heterodimer structures suggests an explanation for the loss of catalytic activity in the homod[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28587922
BRCC3 affects JNK
| 2
BRCC3 phosphorylates JNK.
| 1
BRCC3 leads to the phosphorylation of JNK. 1 / 1
| 1
reach
"Priming requires IRAK1 activation and proteasome dependent ERK activation (with downstream MEK1/2 activation), and it involves post-translational modifications including : (i) BRCC3 mediated NLRP3 deubiquitination, (ii) LUBAC mediated ASC ubiquitination, and (iii) SYK- and JNK dependent ASC phosphorylation."
25879282
BRCC3 deubiquitinates JNK.
| 1
BRCC3 leads to the deubiquitination of JNK. 1 / 1
| 1
reach
"Priming requires IRAK1 activation and proteasome dependent ERK activation (with downstream MEK1/2 activation), and it involves post-translational modifications including : (i) BRCC3 mediated NLRP3 deubiquitination, (ii) LUBAC mediated ASC ubiquitination, and (iii) SYK- and JNK dependent ASC phosphorylation."
25879282
BRCC3 affects IFNAR1
| 2
BRCC3 inhibits IFNAR1.
| 1
BRCC3 inhibits IFNAR1. 1 / 1
| 1
reach
"Importantly, HSV-1-induced BRCC36 degradation promotes downmodulation of IFN-I receptor IFNAR1, thus restricting host IFN-I antiviral response to facilitate HSV-1 early infection."
33857816
BRCC3 deubiquitinates IFNAR1.
| 1
BRCC3 deubiquitinates IFNAR1. 1 / 1
| 1
reach
"Dr. Greenberg group from University of Pennsylvania showed that BRCC36 containing deubiquitinating complex BRISC which is also a sister protein complex of nuclear RAP80-BRCA1 complex, deubiquitinates type I interferon receptor (IFNAR1), resulting in its delayed lysosomal dependent degradation."
27211605
BRCC3 affects HDAC1
1 | 1
BRCC3 binds HDAC1. 2 / 2
1 | 1
biogrid
No evidence text available
22863883
reach
"BRCC3 interacts and stabilizes HDAC1 or PWWP2B individually (Figure S7c,d, Supporting Information), and the presence of PWWP2B could further augment the BRCC3 interacting with and stabilizing HDAC1 protein (Figure S7c,d, Supporting Information, see the last lane in each Figure)."
34180153
BRCC3 affects H2AX
1 | 1
BRCC3 deubiquitinates H2AX. 2 / 2
1 | 1
reach
"BRCC36 de-ubiquitinates H2A/H2AX and RAP80."
31769469
ubibrowser
"BRCA1/2-containing complex36 (BRCC36) is one of the DUBs which localizes at the site of DSBs as a part of the RAP80 complex and deubiquitinates RNF8-dependent γHA2X ubiquitination"
28778421
BRCC3 affects H2AC11
2 |
BRCC3 inhibits H2AC11.
1 |
BRCC3 inhibits H2AC11. 1 / 1
1 |
signor
"Brcc36 regulates the abundance of lys(63)-linked ubiquitin chains at chromatin and that one of its substrates is diubiquitinated histone h2a"
20656690
BRCC3 deubiquitinates H2AC11.
1 |
BRCC3 deubiquitinates H2AC11. 1 / 1
1 |
signor
"Brcc36 regulates the abundance of lys(63)-linked ubiquitin chains at chromatin and that one of its substrates is diubiquitinated histone h2a"
20656690
BRCC3 affects DEF6
2 |
BRCC3 binds DEF6. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
BRCC3 affects COPS5
1 | 1
BRCC3 deubiquitinates COPS5.
| 1
BRCC3 deubiquitinates COPS5. 1 / 1
| 1
reach
"To identify the DUB associated with NALP7, we over-expressed plasmids expressing several candidate DUBs including BRCC3, which deubiquitinates NALP3, COPS5, STAMBPL1, USP7 and the endosome associated DUBs, STAMBP and USP8."
28492230
BRCC3 binds COPS5.
1 |
COPS5 binds BRCC3. 1 / 1
1 |
biogrid
No evidence text available
19214193
BRCC3 affects BRISC deubiquitase
| 2
BRCC3 binds BRISC deubiquitase. 2 / 2
| 2
reach
"Although Sagnier et al. [XREF_BIBR] suggested that autophagy selectively degrades HIV-1 Tat through a ubiquitin independent interaction with SQSTM1, Xu et al. demonstrated that HIV-1 Tat undergoes K63 polyubiquitination, a mark recognised by SQSTM1 and the NBR1 autophagy cargo receptor [XREF_BIBR, XREF_BIBR, XREF_BIBR], complexes with the CMA specific chaperone HSPA8 and is subjected to K63Ub selective autophagy mediated by serine hydroxymethyltransferase (SHMT) 1, SHMT2 and the BRCC36 and BRISC deubiquitase complex [XREF_BIBR]."
| PMC
reach
"Here we show that SHMT1,2 and the BRCC36 and BRISC deubiquitase complex are novel and selective regulators of Tat K63, but not K48, ubiquitylation, and its degradation through selective autophagy in T cells."
29791506
BRCA1 affects BABAM2
| 2
BRCA1 binds BABAM2, BRCC3, and BARD1. 2 / 2
| 2
reach
"Furthermore, it has been demonstrated that in M-phase cells Rap80 exists in complex with the BRCA1, BARD1, BRCC36, and BRCC45 complex which is very abundant and its association is dependent on BRCC36 [XREF_BIBR]."
24832651
reach
"Fifth, through reconstitution of the BRCA1, BARD1, BRCC36, and BRE complex it demonstrates a role for BRCC36 and BRE in modulation of BRCA1 and BARD1 E3 ubiquitin ligase activity."
14636569
ANRIL affects BRCC3
| 2
ANRIL increases the amount of BRCC3.
| 1
ANRIL increases the amount of BRCC3. 1 / 1
| 1
reach
"Luciferase reporter assay and in vitro rescue experiment confirmed that ANRIL promoted NLRP3 inflammasome activation by up-regulating BRCC3 expression via sponging miR-122-5p."
30347231
ANRIL binds BRCC3.
| 1
BRCC3 binds ANRIL. 1 / 1
| 1
reach
"The interaction between ANRIL, miR-122-5p and BRCC3 were studied using luciferase reporter assay."
30347231
ABRAXAS1 affects Abraxas, BARD1, BRCA1, BRCC3, and MERIT
| 2
BRCA1 binds BRCC3, ABRAXAS1, BARD1, Abraxas, and MERIT. 2 / 2
| 2
reach
"RAP80 facilitates the recruitment of the BRCA1, BARD1, Abraxas, CCDC98, MERIT, and BRCC36 complex to IRIF."
22896338
reach
"Receptor associated protein 80 (RAP80 or UIMC1) is an ubiquitin interaction motif containing (UIMC) nuclear protein that facilitates the recruitment of the BRCA1, BARD1, Abraxas, CCDC98, MERIT, and BRCC36 complex to DNA damage sites, which initiates DDR.6, 7, 8, 9, 10, 11, 12, 13 Although previous studies indicate that defective RAP80 function and expression could lead to genomic instability and subsequent increased early stage cancer risk,14, 15, 16 the possible role of RAP80 on tumor progression and malignancy in later stages, including EMT derived metastasis, has not been investigated."
26748910
ABRAXAS affects UIMC1
| 2
BRCC3 binds UIMC1 and ABRAXAS. 2 / 2
| 2
reach
"The requirement for POH1 for generation of a devoid core can be relieved by depletion of any member of the RAP80, BRCC36, and ABRAXAS complex."
24013561
reach
"MERIT40 knockdown unravel the negative effect on the RAP80, BRCC36 and ABRAXAS complex irrespective of BRCA1."
24667604
Urethane affects BRCC3
1 |
Urethane decreases the amount of BRCC3. 1 / 1
1 |
ctd
No evidence text available
28818685
Tris(1,3-dichloro-2-propyl)phosphate decreases the amount of BRCC3. 1 / 1
1 |
ctd
No evidence text available
26179874
Torcetrapib affects BRCC3
1 |
Torcetrapib increases the amount of BRCC3. 1 / 1
1 |
ctd
No evidence text available
23228038
Thiolutin affects BRCC3
| 1
Thiolutin inhibits BRCC3. 1 / 1
| 1
reach
"Furthermore, it has recently been demonstrated that the zinc chelating activity of the antibiotic thiolutin inhibits the JAMM metalloprotease activity of the eukaryotic Rpn11 proteasome-complex homologues, the deNEDDylation function of the JAMM metalloproteases Csn5 (of the COP9 signalosome) and also the activities of the eukaryotic BRCC36 enzyme (a deubiquitylase specific to K63 linkages in the BRCA1 and BRCA2 complex) 54."
29066714
Sunitinib affects BRCC3
1 |
Sunitinib decreases the amount of BRCC3. 1 / 1
1 |
ctd
No evidence text available
31533062
Sodium dichromate affects BRCC3
1 |
Sodium dichromate increases the amount of BRCC3. 1 / 1
1 |
ctd
No evidence text available
22155349
Resveratrol affects BRCC3
1 |
Resveratrol decreases the amount of BRCC3. 1 / 1
1 |
ctd
No evidence text available
25905778
reach
"We further identified that the ROS overproduction and mtDNA oxidative damage with upregulated deubiquitinase BRCC36, a potential molecular mechanism by which ocular surface epithelium initiates innate immune response to the environmental stress."
28238526
Promethazine affects BRCC3
1 |
Promethazine decreases the amount of BRCC3. 1 / 1
1 |
ctd
No evidence text available
26011634
Pregnenolone 16alpha-carbonitrile decreases the amount of BRCC3. 1 / 1
1 |
ctd
No evidence text available
19162173
Potassium chromate decreases the amount of BRCC3. 1 / 1
1 |
ctd
No evidence text available
22714537
Polyubiquitin foci affects BRCC3
| 1
Polyubiquitin foci activates BRCC3. 1 / 1
| 1
reach
"K63-linked polyubiquitin foci are elevated both at baseline and post-IR in BRCC36 depleted cells and can be restored upon rescue with catalytically active BRCC36 [65,113,115,116]."
32708614
Polyphenol affects BRCC3
1 |
Polyphenol decreases the amount of BRCC3. 1 / 1
1 |
ctd
No evidence text available
15465739
Piroxicam affects BRCC3
1 |
Piroxicam decreases the amount of BRCC3. 1 / 1
1 |
ctd
No evidence text available
21858171
Pentachlorophenol affects BRCC3
1 |
Pentachlorophenol increases the amount of BRCC3. 1 / 1
1 |
ctd
No evidence text available
23892564
Ochratoxin A affects BRCC3
1 |
Ochratoxin A decreases the amount of BRCC3. 1 / 1
1 |
ctd
No evidence text available
23358140
Nickel sulfate affects BRCC3
1 |
Nickel sulfate decreases the amount of BRCC3. 1 / 1
1 |
ctd
No evidence text available
22714537
Nickel monoxide affects BRCC3
1 |
Nickel monoxide decreases the amount of BRCC3. 1 / 1
1 |
ctd
No evidence text available
19167457
Mono(2-ethylhexyl) phthalate decreases the amount of BRCC3. 1 / 1
1 |
ctd
No evidence text available
31059758
MiR-122-5p affects BRCC3
| 1
BRCC3 binds miR-122-5p. 1 / 1
| 1
reach
"The interaction between ANRIL, miR-122-5p and BRCC3 were studied using luciferase reporter assay."
30347231
Methylmercury chloride decreases the amount of BRCC3. 1 / 1
1 |
ctd
No evidence text available
28001369
Methapyrilene affects BRCC3
1 |
Methapyrilene decreases the amount of BRCC3. 1 / 1
1 |
ctd
No evidence text available
30467583
reach
"miR-US25–1-5p also contributes to aggravation of the apoptosis promoted by oxidized low-density lipoprotein in infected endothelial cells by targeting the 5′UTR of BRCC3 (BRCA1/BRCA2-containing complex subunit 3) and down-regulating its expression [79]."
32164742
LncRNA ANRIL affects BRCC3
| 1
LncRNA ANRIL activates BRCC3. 1 / 1
| 1
reach
"It was proved that in UAN pathogenesis, lncRNA ANRIL sponged miR-122-5p thereby inhibiting the negative regulation of BRCC3 by miR-122-5p."
33101288
Hsa-miR-92a-3p affects BRCC3
1 |
Hsa-miR-92a-3p decreases the amount of BRCC3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Hsa-miR-7977 affects BRCC3
1 |
Hsa-miR-7977 decreases the amount of BRCC3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-7705 affects BRCC3
1 |
Hsa-miR-7705 decreases the amount of BRCC3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22100165
Hsa-miR-7162-5p affects BRCC3
1 |
Hsa-miR-7162-5p decreases the amount of BRCC3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-6849-3p affects BRCC3
1 |
Hsa-miR-6849-3p decreases the amount of BRCC3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-6715b-5p affects BRCC3
1 |
Hsa-miR-6715b-5p decreases the amount of BRCC3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-670-3p affects BRCC3
1 |
Hsa-miR-670-3p decreases the amount of BRCC3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-596 affects BRCC3
1 |
Hsa-miR-596 decreases the amount of BRCC3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-573 affects BRCC3
1 |
Hsa-miR-573 decreases the amount of BRCC3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22100165
Hsa-miR-516b-3p affects BRCC3
1 |
Hsa-miR-516b-3p decreases the amount of BRCC3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-516a-3p affects BRCC3
1 |
Hsa-miR-516a-3p decreases the amount of BRCC3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-4743-3p affects BRCC3
1 |
Hsa-miR-4743-3p decreases the amount of BRCC3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-4742-5p affects BRCC3
1 |
Hsa-miR-4742-5p decreases the amount of BRCC3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-4692 affects BRCC3
1 |
Hsa-miR-4692 decreases the amount of BRCC3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-4691-3p affects BRCC3
1 |
Hsa-miR-4691-3p decreases the amount of BRCC3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-4652-3p affects BRCC3
1 |
Hsa-miR-4652-3p decreases the amount of BRCC3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-4635 affects BRCC3
1 |
Hsa-miR-4635 decreases the amount of BRCC3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22100165
Hsa-miR-4514 affects BRCC3
1 |
Hsa-miR-4514 decreases the amount of BRCC3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-4269 affects BRCC3
1 |
Hsa-miR-4269 decreases the amount of BRCC3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-3616-5p affects BRCC3
1 |
Hsa-miR-3616-5p decreases the amount of BRCC3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22100165
Hsa-miR-3184-3p affects BRCC3
1 |
Hsa-miR-3184-3p decreases the amount of BRCC3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22100165
Hsa-miR-3157-5p affects BRCC3
1 |
Hsa-miR-3157-5p decreases the amount of BRCC3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-2115-5p affects BRCC3
1 |
Hsa-miR-2115-5p decreases the amount of BRCC3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-208b-5p affects BRCC3
1 |
Hsa-miR-208b-5p decreases the amount of BRCC3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22100165
Hsa-miR-208a-5p affects BRCC3
1 |
Hsa-miR-208a-5p decreases the amount of BRCC3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22100165
Hsa-miR-193b-3p affects BRCC3
1 |
Hsa-miR-193b-3p decreases the amount of BRCC3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Hsa-miR-1264 affects BRCC3
1 |
Hsa-miR-1264 decreases the amount of BRCC3. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22100165
Hexabromocyclododecane increases the amount of BRCC3. 1 / 1
1 |
ctd
No evidence text available
29177809
Formaldehyde affects BRCC3
1 |
Formaldehyde decreases the amount of BRCC3. 1 / 1
1 |
ctd
No evidence text available
23649840
Fenofibrate affects BRCC3
1 |
Fenofibrate increases the amount of BRCC3. 1 / 1
1 |
ctd
No evidence text available
21318169
Endosulfan affects BRCC3
1 |
Endosulfan increases the amount of BRCC3. 1 / 1
1 |
ctd
No evidence text available
29391264
Cyclosporin A affects BRCC3
1 |
Cyclosporin A decreases the amount of BRCC3. 1 / 1
1 |
ctd
No evidence text available
25562108
Copper(II) sulfate decreases the amount of BRCC3. 1 / 1
1 |
ctd
No evidence text available
19549813
Celastrol affects BRCC3
| 1
reach
"It was demonstrated that celastrol binds directly to BRCC3, a NLRP3 DUB that prevents further deubiquitination of NLRP3 and the formation of an NLRP3 inflammasome complex."
| PMC
Bortezomib affects BRCC3
1 |
Bortezomib decreases the amount of BRCC3. 1 / 1
1 |
ctd
No evidence text available
20977926
Benzo[a]pyrene diol epoxide I increases the amount of BRCC3. 1 / 1
1 |
ctd
No evidence text available
26238291
Amiodarone affects BRCC3
1 |
Amiodarone increases the amount of BRCC3. 1 / 1
1 |
ctd
No evidence text available
19774075
Acetamide affects BRCC3
1 |
Acetamide decreases the amount of BRCC3. 1 / 1
1 |
ctd
No evidence text available
31881176
Abrine affects BRCC3
1 |
Abrine decreases the amount of BRCC3. 1 / 1
1 |
ctd
No evidence text available
31054353
Zinc affects BRCC3
1 |
Zinc inhibits BRCC3. 1 / 1
1 |
drugbank
No evidence text available
26344097
Zinc chloride affects BRCC3
1 |
Zinc chloride activates BRCC3. 1 / 1
1 |
drugbank
No evidence text available
26344097
Zinc acetate affects BRCC3
1 |
Zinc acetate inhibits BRCC3. 1 / 1
1 |
drugbank
No evidence text available
26344097
WDHD1 affects BRCC3
1 |
WDHD1 binds BRCC3. 1 / 1
1 |
biogrid
No evidence text available
22863883
Vehicle Emissions affects BRCC3
1 |
Vehicle Emissions demethylates BRCC3. 1 / 1
1 |
ctd
No evidence text available
25560391
VDR affects BRCC3
| 1
VDR inhibits BRCC3. 1 / 1
| 1
eidos
"VD3-induced Ub-NLRP3 expression , NLRP3 inflammasome inactivation , and hyperinflammation inhibition were improved by the BRCC3 inhibitor or BRCC3 siRNA , which were attenuated by the vitamin D receptor ( VDR ) antagonist or VDR siRNA in HBE-N cells ."
37361896
VD3 affects BRCC3
| 1
VD3 increases the amount of BRCC3. 1 / 1
| 1
reach
"Moreover, VD3 increased NLRP3 ubiquitination (Ub-NLRP3) expression and the binding of the VDR with NLRP3, with decreased BRCA1/BRCA2-containing complex subunit 3 (BRCC3) expression and NLRP3-BRCC3 association."
37361896
USP7 affects BRCC3
1 |
USP7 binds BRCC3. 1 / 1
1 |
biogrid
No evidence text available
19615732
US26 affects BRCC3
1 |
BRCC3 binds US26. 1 / 1
1 |
virhostnet
No evidence text available
31873071
UIMC1 affects BARD1
| 1
reach
"As discussed in Section 5.7, SUMOylation of BRCA1 is a prerequisite for BRCA1 's efficient in vitro and in vivo ubiquitylation activity [602,603], and autoubiquitylation [1038,1039] may promote this a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22743550
UIMC1 affects 63
| 1
BRCC3 binds UIMC1 and 63. 1 / 1
| 1
reach
"The Rap80 and Brcc36 complex furthermore removes lysine 63 linked polyubiquitin chains from the chromatin and is thus also involved in the termination of RNF8-Ubc13-mediated polyubiquitination once the lesion has been repaired [XREF_BIBR]."
21037856
UBE2D1 affects BRCC3
1 |
UBE2D1 binds BRCC3. 1 / 1
1 |
biogrid
No evidence text available
14636569
Thiolutin affects BRCC3
| 1
Thiolutin inhibits BRCC3. 1 / 1
| 1
reach
"Thiolutin also inhibits the JAMM metalloproteases Csn5, the deneddylase of the COP9 signalosome; AMSH, which regulates ubiquitin dependent sorting of cell-surface receptors; and BRCC36, a K63 specific deubiquitinase of the BRCC36 containing isopeptidase complex and the BRCA1, BRCA2, and containing complex."
28459440
TRIM28 affects BRCC3
1 |
TRIM28 binds BRCC3. 1 / 1
1 |
biogrid
No evidence text available
22863883
TNS1 affects BRCC3
1 |
TNS1 binds BRCC3. 1 / 1
1 |
biogrid
No evidence text available
27880917
TFDP3 affects BRCC3
1 |
BRCC3 binds TFDP3. 1 / 1
1 |
biogrid
No evidence text available
26186194
TBPL1 affects BRCC3
| 1
TBPL1 binds BRCC3. 1 / 1
| 1
reach
"Exposure of ALT dependent tumor cells to a subset of PARPi induced a conformational change in PARP1 that limited binding to MRE11 and BRCC3 and delayed release of the TRF2 mediated block on lethal telomeric fusion."
33952676
SUPT16H affects BRCC3
1 |
SUPT16H binds BRCC3. 1 / 1
1 |
biogrid
No evidence text available
19615732
STAMBPL1 affects BRCC3
| 1
STAMBPL1 binds BRCC3. 1 / 1
| 1
reach
"Thus, it is likely that BRCC36 and AMSH-LP bind K63-Ub 2 similarly.Comparison of the BRCC36 homodimer and heterodimer structures suggests an explanation for the loss of catalytic activity in the homod[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28587922
SPAG9 affects BRCC3
1 |
SPAG9 binds BRCC3. 1 / 1
1 |
biogrid
No evidence text available
22863883
SMARCD1 affects BRCC3
1 |
SMARCD1 binds BRCC3. 1 / 1
1 |
biogrid
No evidence text available
26186194
SF3A1 affects BRCC3
1 |
SF3A1 binds BRCC3. 1 / 1
1 |
biogrid
No evidence text available
22863883
RP23-244N6.4 affects BRCC3
1 |
BRCC3 binds RP23-244N6.4. 1 / 1
1 |
biogrid
No evidence text available
26496610
RABEP2 affects BRCC3
1 |
BRCC3 binds RABEP2. 1 / 1
1 |
biogrid
No evidence text available
22863883
Proteasome affects BRCC3
| 1
Proteasome activates BRCC3. 1 / 1
| 1
reach
"Interestingly, MPN- subunits of the 26S proteasome lid and of BRCC36 containing complexes are able to activate their otherwise inactive catalytic subunits, Rpn11 and POH1 and BRCC36, respectively XREF_BIBR."
25144743
PYCARD affects BRCC3
| 1
PYCARD binds BRCC3. 1 / 1
| 1
isi
"Mechanism study revealed that celastrol could interdict K63 deubiquitination of NLRP3, which may concern interaction of celastrol and BRCA1/BRCA2-containing complex subunit 3 (BRCC3), and thereby prohibited the formation of NLRP3, ASC and pro-caspase-1 complex to block the generation of mature IL-1beta."
33130474
PRSS27 affects BRCC3
| 1
PRSS27 binds BRCC3. 1 / 1
| 1
reach
"The MPN + domain protein BRCC36 associates with pseudo-DUB MPN - proteins KIAA0157 or Abraxas, which are essential for BRCC36 enzymatic activity."
26344097
PPP4R3A affects BRCC3
1 |
PPP4R3A binds BRCC3. 1 / 1
1 |
biogrid
No evidence text available
22863883
PPAR affects BRCC3
| 1
PPAR activates BRCC3. 1 / 1
| 1
reach
"Our research found that BRCC36 aggravated intestinal mucosal barrier injury caused by BMP2 (Bone morphogenetic protein 2) after I/R by downregulating PPARγ (Peroxisome proliferator-activated receptor-γ) signaling."
34888627
PAXIP1 affects BRCC3
1 |
BRCC3 binds PAXIP1. 1 / 1
1 |
biogrid
No evidence text available
22990118
PARP1 affects BRCC3
| 1
PARP1 inhibits BRCC3. 1 / 1
| 1
reach
"By recruiting MRE11 and BRCC3 to stabilize TRF2 at the ends of telomeres, PARP1 blocked chromosomal fusion."
33952676
BRCC3 is modified
1 |
BRCC3 is phosphorylated on S231. 1 / 1
1 |
hprd
No evidence text available
20068231
NleA affects BRCC3
| 1
NleA inhibits BRCC3. 1 / 1
| 1
reach
"Another possibility is that because BRCC3 is the sole identified host deubiquitinase of NLRP3, the association of NleA and NLRP3 may impede the access of BRCC3 to the sensor protein."
27617233
NR3C1 affects BRCC3
1 |
BRCC3 binds NR3C1. 1 / 1
1 |
biogrid
No evidence text available
22863883
NLRP6 affects BRCC3
| 1
NLRP6 binds BRCC3. 1 / 1
| 1
reach
"Interestingly, the result of co-immunoprecipitation showed that the interaction between BRCC3 and NLRP6 was enhanced after model, and the result of immunofluorescence showed that the co-localization of BRCC3 and NLRP6 was increased."
33979701
NLRP3 agonists affects BRCC3
| 1
NLRP3 agonists activates BRCC3. 1 / 1
| 1
eidos
"Moreover , BRCC3 [ 18 ] , STING [ 19 ] and ABRO1 [ 20 ] can be activated by NLRP3 agonists , such as ATP , to promote the deubiquitination and sensitivity of NLRP3 ."
| PMC
NEAT1 affects BRCC3
| 1
NEAT1 increases the amount of BRCC3. 1 / 1
| 1
reach
"NEAT1 positively regulated BRCC3 expression via competitively binding with miR‑204."
34850961
NDUFA10 affects BRCC3
1 |
BRCC3 binds NDUFA10. 1 / 1
1 |
biogrid
No evidence text available
19615732
NAC affects BRCC3
| 1
NAC inhibits BRCC3. 1 / 1
| 1
reach
"Anti-oxidants L-carnitine and NAC significantly suppress ROS overproduction and BRCC36 production, block caspase-8 activation, and largely reverse or restore the imbalance of activated NLRP3 and suppressed NLRP6."
28238526
MTA2 affects BRCC3
1 |
BRCC3 binds MTA2. 1 / 1
1 |
biogrid
No evidence text available
22863883
MRPL1 affects BRCC3
1 |
MRPL1 binds BRCC3. 1 / 1
1 |
biogrid
No evidence text available
26496610
MRE11 affects BRCC3
| 1
BRCC3 binds MRE11. 1 / 1
| 1
reach
"MRE11 binds BRCC3, which in turn deubiquitinates γH2AX deposited at exposed telomeric DNA ends and limits RNF168 recruitment to the telomere."
34881184
MLN7243 affects BRCC3
1 |
MLN7243 desumoylates BRCC3. 1 / 1
1 |
ctd
No evidence text available
31285264
MDC1 affects BRCC3
1 |
MDC1 binds BRCC3. 1 / 1
1 |
biogrid
No evidence text available
22990118
MCM2 affects BRCC3
1 |
BRCC3 binds MCM2. 1 / 1
1 |
biogrid
No evidence text available
19615732
LARP7 affects BRCC3
1 |
BRCC3 binds LARP7. 1 / 1
1 |
biogrid
No evidence text available
22863883
K 7174 affects BRCC3
1 |
K 7174 decreases the amount of BRCC3. 1 / 1
1 |
ctd
No evidence text available
24086573
JOSD2 affects BRCC3
| 1
BRCC3 binds JOSD2. 1 / 1
| 1
isi
"This was mediated by enhanced deubiquitination of NLRP3 via binding with deubiquitinases BRCC3 and JOSD2, which are highly expressed in myeloid cells."
32941940
HUWE1 affects BRCC3
1 |
BRCC3 binds HUWE1. 1 / 1
1 |
biogrid
No evidence text available
22863883
HNRNPR affects BRCC3
1 |
BRCC3 binds HNRNPR. 1 / 1
1 |
biogrid
No evidence text available
22863883
GST affects BRCC3
| 1
GST binds BRCC3. 1 / 1
| 1
reach
"First, endogenous NuMA was immunoprecipitated from mitotic HeLa cells by using anti-NuMA antibody (XREF_FIG), and WT or DUB inactive mutant (QSQ) of GST and BRCC36 complex was purified from Sf9 insect cells (XREF_FIG)."
26195665
GRB2 affects BRCC3
1 |
BRCC3 binds GRB2. 1 / 1
1 |
biogrid
No evidence text available
19380743
GPHN affects BRCC3
1 |
GPHN binds BRCC3. 1 / 1
1 |
biogrid
No evidence text available
22863883
GGN1 affects BRCC3
| 1
BRCC3 binds GGN1. 1 / 1
| 1
reach
"We demonstrated that the largest isoform GGN1 interacts with DNA repair proteins FANCL, FANCD2 and BRCC36 (BRCA1 and BRCA2 containing complex, subunit 3, alias BRCC3) in the mouse testis."
23451117
Flavonoids affects BRCC3
1 |
Flavonoids decreases the amount of BRCC3. 1 / 1
1 |
ctd
No evidence text available
15465739
FANCI affects BRCC3
| 1
FANCI activates BRCC3. 1 / 1
| 1
eidos
"Our global proteomics experiment also revealed several commonly downregulated key DNA repair proteins ( Figure 5C ) such as ( i ) POLD1 which synthesizes DNA during repair ,26 ( ii ) USP47 which facilitates base-excision repair ,27 ( iii ) FANCI which mediates the repair of DNA double strand breaks and interstrand crosslinks ,28 and ( iv ) BRCC3 which stabilizes the accumulation of BRCA1 at DNA breaks ."
33705657
FANCA affects BRCC3
1 |
BRCC3 binds FANCA. 1 / 1
1 |
biogrid
No evidence text available
28215707
EXOC8 affects BRCC3
1 |
BRCC3 binds EXOC8. 1 / 1
1 |
biogrid
No evidence text available
19615732
ELP1 affects BRCC3
| 1
ELP1 inhibits BRCC3. 1 / 1
| 1
reach
"Moreover, in the absence of irradiation, knockout of Elp1 from MEFs caused more Babam1 and Brcc3 mRNA to be distributed in the LMW and non-polysomal fractions (Additional file 1: Fig. S11B)."
34819065
ELK1 affects BRCC3
1 |
ELK1 decreases the amount of BRCC3. 1 / 1
1 |
biopax:msigdb
No evidence text available
E3_Ub_ligase affects BRCC3
| 1
E3_Ub_ligase leads to the ubiquitination of BRCC3. 1 / 1
| 1
reach
"The HECT-type E3 ubiquitin ligase WWP2 modulates BRCC3 ubiquitination and degradation."
33107021
E2F5 affects BRCC3
1 |
BRCC3 binds E2F5. 1 / 1
1 |
biogrid
No evidence text available
19615732
Dietary Fats affects BRCC3
1 |
Dietary Fats increases the amount of BRCC3. 1 / 1
1 |
ctd
No evidence text available
19467301
Deletion BRCC3 affects BRCC3
| 1
Deletion BRCC3 inhibits BRCC3. 1 / 1
| 1
eidos
"Deletion of BRCC3 / MTCP1 ( Xq28 ) leads to loss of BRCC3 / MTCP1 gene expression ."
33776470
DDSB site affects BRCC3
| 1
BRCC3 binds DDSB site. 1 / 1
| 1
reach
"Alongside the E3 activity of BRCA1, the BRCA1 A-complex anchoring to the DDSB site binds BRCC36 deubiquitinylase [46]."
23416467
DDOST affects BRCC3
1 |
BRCC3 binds DDOST. 1 / 1
1 |
biogrid
No evidence text available
19615732
Cyclin affects BRCC3
| 1
Cyclin increases the amount of BRCC3. 1 / 1
| 1
reach
"Interestingly, upregulating cyclin dependent kinase 5 (Cdk5) increased the expression of BRCC3 in HEK293cell, while inhibition of Cdk5 decreased the upregulated BRCC3 level in MPP + -induced PD cell model."
31787240
CRISPR affects BRCC3
| 1
CRISPR inhibits BRCC3. 1 / 1
| 1
reach
"Inactivation of BRCC3 by CRISPR and Cas9 resulted in improved proliferation in t (8; 21) (q22; q22.1) positive AML cell lines and together with expression of AML1-ETO induced unlimited self-renewal in mouse hematopoietic progenitor cells in vitro."
31576005
COPS5 affects BRCC3
1 |
COPS5 binds BRCC3. 1 / 1
1 |
biogrid
No evidence text available
19214193
CENPA affects BRCC3
1 |
CENPA binds BRCC3. 1 / 1
1 |
biogrid
No evidence text available
26496610
CDC25A affects BRCC3
| 1
CDC25A binds BRCC3. 1 / 1
| 1
reach
"Furthermore, we failed to detect any interaction between BRCC36 and CDC25A making it unlikely to be involved in CDC25A regulation."
29416040
CD2AP affects BRCC3
1 |
CD2AP binds BRCC3. 1 / 1
1 |
biogrid
No evidence text available
22863883
CCDC6 affects BRCC3
1 |
CCDC6 binds BRCC3. 1 / 1
1 |
biogrid
No evidence text available
22863883
CAND1 affects BRCC3
1 |
BRCC3 binds CAND1. 1 / 1
1 |
biogrid
No evidence text available
19615732
C60 fullerene affects BRCC3
1 |
C60 fullerene decreases the amount of BRCC3. 1 / 1
1 |
ctd
No evidence text available
19167457
BRCC3-KD2 affects BRCC3
| 1
BRCC3-KD2 inhibits BRCC3. 1 / 1
| 1
reach
"Through QPCR and western blot analysis, we found that BRCC3-KD1 and BRCC3-KD2 suppressed the production of BRCC3 mRNA and protein production efficiently in U251 and A172 cells."
25337721
BRCC3-KD1 affects BRCC3
| 1
BRCC3-KD1 inhibits BRCC3. 1 / 1
| 1
reach
"Through QPCR and western blot analysis, we found that BRCC3-KD1 and BRCC3-KD2 suppressed the production of BRCC3 mRNA and protein production efficiently in U251 and A172 cells."
25337721
reach
"BRCC3 knockdown leads to an increase in NLRP3 ubiquitination, and the DUB activity of BRCC3 is required for caspase-1 activation and IL-1beta processing, but not for LPS induced transcription of pro-IL-1beta or of NLRP3 itself XREF_BIBR."
24375678
BRCC3 affects sub
| 1
BRCC3 activates sub. 1 / 1
| 1
reach
"Altogether, the counterbalance of the K63Ub machinery and BRCC3 triggered DUB machinery are important for the cellular trafficking of myelin proteins and OL differentiation."
31184779
BRCC3 affects rapid STAT1
| 1
BRCC3 activates rapid STAT1. 1 / 1
| 1
eidos
"More specifically , BRCC36 deficiency leads to a rapid downregulation of STAT1 during viral infection , whereas complementation by BRCC36 can rescue the STAT1 expression levels and suppress virus infection ( 110 ) ."
34707613
BRCC3 affects miR-122-5p
| 1
BRCC3 binds miR-122-5p. 1 / 1
| 1
reach
"The interaction between ANRIL, miR-122-5p and BRCC3 were studied using luciferase reporter assay."
30347231
BRCC3 affects mature IL-1beta
| 1
BRCC3 activates mature IL-1beta. 1 / 1
| 1
reach
"Therefore, we conclude that BRCC3 might be involved in regulating deubiquitination of NLRP3.Consistent with an activator of NLRP3 activity, knockdown of BRCC3 inhibited mature IL-1beta and activated c[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23246432
BRCC3 leads to the deubiquitination of lipopolysaccharide. 1 / 1
| 1
reach
"Recently, BRCC3 in the cytosol has been reported to promote the inflammasome activation by deubiquitinating NLRP3 in LPS primed macrophages [XREF_BIBR]."
25337721
BRCC3 affects intestinal mucosal injury caused BMP2 ischemia-reperfusion PPARgamma signaling
| 1
BRCC3 inhibits intestinal mucosal injury caused BMP2 ischemia-reperfusion PPARgamma signaling. 1 / 1
| 1
eidos
"BRCC36 promotes intestinal mucosal barrier injury caused by BMP2 after ischemia-reperfusion via inhibiting PPARgamma signaling ."
34888627
eidos
"Particularly , Benedicte et al. found that , knockdown of BRCC3 ( a component of the BRISC complex ) completely inhibited caspase-1 cleavage and IL-1beta secretion ."
33627128
BRCC3 activates innate immune response. 1 / 1
| 1
reach
"We further identified that the ROS overproduction and mtDNA oxidative damage with upregulated deubiquitinase BRCC36, a potential molecular mechanism by which ocular surface epithelium initiates innate immune response to the environmental stress."
28238526
reach
"BRCC3 siRNA could reduce nerve damage and inflammation."
33979701
BRCC3 affects downstream inflammasome
| 1
BRCC3 activates downstream inflammasome. 1 / 1
| 1
eidos
"Mechanistically , BRCC3 promotes downstream inflammasome activation through specifically interacting with and deubiquitinating LRR domain of NLRP3 [ 9 ] ."
33627128
BRCC3 affects deubiquitination such modification
| 1
BRCC3 activates deubiquitination such modification. 1 / 1
| 1
eidos
"TLR and ROS signaling can increase the levels of NLRP3 via BRCA1 / BRCA2-containing complex subunit 3 ( BRCC3 ) which mediates deubiquitination of the LRR domain of NLRP3 and such modification is essential for its activation ( Py et al ., 2013 ) ."
30405440
BRCC3 affects deubiquitination sensitivity NLRP3
| 1
BRCC3 activates deubiquitination sensitivity NLRP3. 1 / 1
| 1
eidos
"Moreover , BRCC3 [ 18 ] , STING [ 19 ] and ABRO1 [ 20 ] can be activated by NLRP3 agonists , such as ATP , to promote the deubiquitination and sensitivity of NLRP3 ."
| PMC
BRCC3 affects deubiquitinate NLRP3
| 1
BRCC3 activates deubiquitinate NLRP3. 1 / 1
| 1
eidos
"There are two key steps between NLRP3 activation and inflammation : firstly priming , in which stimuli activate NF-kappaB signaling via Toll-like receptors , IL-1 receptors , TNFR1 and TNFR2 ; NF-kappaB improves the level of transcription of pro-IL-1beta , pro-IL-18 , and NLRP3 , and secondly , activation , in which DAMPs and other stimuli promote inflammasome assembly via activating BRCC3 to deubiquitinate NLRP3 [ 134 ] ."
35046517
BRCC3 inhibits cytokine secretion. 1 / 1
| 1
reach
"SYVN1-mediated BRCC3 down-regulation promoted NLRP3 ubiquitination and reduced pro-inflammatory cytokine secretion."
34874278
BRCC3 affects cyclinB1
| 1
BRCC3 decreases the amount of cyclinB1. 1 / 1
| 1
reach
"The results of our study showed that BRCC3 knockdown upregulated cyclinB1 expression after irradiation compared to the control cells."
26024915
BRCC3 activates cell population proliferation. 1 / 1
| 1
reach
"Overexpression of BRCC3 Increased Cell Proliferation and Migration."
34604222
BRCC3 affects cell migration
| 1
reach
"The cell migration and invasion of U251 and A172 cells are also impaired by BRCC3 knockdown."
25337721
BRCC3 affects cell cycle
| 1
BRCC3 inhibits cell cycle. 1 / 1
| 1
reach
"This suggested that BRCC3 knockdown enhanced the G2/M cell cycle arrest induced by ionizing radiation."
26024915
BRCC3 affects celastrol
| 1
reach
"It was demonstrated that celastrol binds directly to BRCC3, a NLRP3 DUB that prevents further deubiquitination of NLRP3 and the formation of an NLRP3 inflammasome complex."
| PMC
BRCC3 affects caspase-1 cleavage
| 1
BRCC3 activates caspase-1 cleavage. 1 / 1
| 1
eidos
"Particularly , Benedicte et al. found that , knockdown of BRCC3 ( a component of the BRISC complex ) completely inhibited caspase-1 cleavage and IL-1beta secretion ."
33627128
BRCC3 affects carmustine
| 1
BRCC3 inhibits carmustine. 1 / 1
| 1
reach
"Moreover, BRCC3 gene knockdown promoted the cell death of U251 and A172 cells in response to BCNU (XREF_SUPPLEMENTARY)."
25337721
BRCC3 affects beta-catenin CRC cells
| 1
BRCC3 activates beta-catenin CRC cells. 1 / 1
| 1
eidos
"Interestingly , we revealed that BRCC36 knockdown decreased beta-catenin expression in CRC cells , suggesting that binding between SHMT2 and BRCC36 may direct BRCC36 activity towards K63-Ub chains conjugated to beta-catenin in CRC cells ."
33456583
BRCC3 affects autophagy
| 1
BRCC3 bound to BRISC deubiquitase activates autophagy. 1 / 1
| 1
reach
"Although Sagnier et al. [XREF_BIBR] suggested that autophagy selectively degrades HIV-1 Tat through a ubiquitin independent interaction with SQSTM1, Xu et al. demonstrated that HIV-1 Tat undergoes K63 polyubiquitination, a mark recognised by SQSTM1 and the NBR1 autophagy cargo receptor [XREF_BIBR, XREF_BIBR, XREF_BIBR], complexes with the CMA specific chaperone HSPA8 and is subjected to K63Ub selective autophagy mediated by serine hydroxymethyltransferase (SHMT) 1, SHMT2 and the BRCC36 and BRISC deubiquitase complex [XREF_BIBR]."
| PMC
BRCC3 affects activation BRCA1
| 1
BRCC3 activates activation BRCA1. 1 / 1
| 1
eidos
"Notably , BRCC36 depletion has been shown to impair activation of BRCA1 and to sensitise breast cancer cells to IR-induced apoptosis [ 146 ] ."
23712866
BRCC3 affects WWP2
1 |
WWP2 binds BRCC3. 1 / 1
1 |
biogrid
No evidence text available
25071155
BRCC3 affects WDHD1
1 |
WDHD1 binds BRCC3. 1 / 1
1 |
biogrid
No evidence text available
22863883
BRCC3 affects Ubiquitin
| 1
BRCC3 activates Ubiquitin. 1 / 1
| 1
reach
"Co-depletion of POH1 and RAP80, BRCC36 or ABRAXAS allows establishment of the 53BP1 and ubiquitin chain-devoid core."
24013561
BRCC3 affects US26
1 |
BRCC3 binds US26. 1 / 1
1 |
virhostnet
No evidence text available
31873071
BRCC3 affects UBE2D1
1 |
UBE2D1 binds BRCC3. 1 / 1
1 |
biogrid
No evidence text available
14636569
BRCC3 affects TYROSINE-KINASE
| 1
BRCC3 inhibits TYROSINE-KINASE. 1 / 1
| 1
trips
"Therefore, CIS3 and JAB inhibit JAK2 tyrosine kinase activity by an essentially similar mechanism."
10421843
BRCC3 affects TRIM28
1 |
TRIM28 binds BRCC3. 1 / 1
1 |
biogrid
No evidence text available
22863883
BRCC3 affects TNS1
1 |
TNS1 binds BRCC3. 1 / 1
1 |
biogrid
No evidence text available
27880917
BRCC3 affects TNFRSF
| 1
BRCC3 activates TNFRSF. 1 / 1
| 1
reach
"We found that BRCC3 increased the activation NF-κB signaling pathway together with the upstream molecules TNFR and TRAF2 (Figure 5A)."
34604222
BRCC3 affects TFDP3
1 |
BRCC3 binds TFDP3. 1 / 1
1 |
biogrid
No evidence text available
26186194
BRCC3 affects TBPL1
| 1
TBPL1 binds BRCC3. 1 / 1
| 1
reach
"Exposure of ALT dependent tumor cells to a subset of PARPi induced a conformational change in PARP1 that limited binding to MRE11 and BRCC3 and delayed release of the TRF2 mediated block on lethal telomeric fusion."
33952676
BRCC3 affects SUPT16H
1 |
SUPT16H binds BRCC3. 1 / 1
1 |
biogrid
No evidence text available
19615732
BRCC3 affects SPAG9
1 |
SPAG9 binds BRCC3. 1 / 1
1 |
biogrid
No evidence text available
22863883
BRCC3 affects SNAI2
| 1
BRCC3 increases the amount of SNAI2. 1 / 1
| 1
reach
"BRCC3 interference in HeLa and SiHa cells was revealed to suppress cell viability, invasion and migration abilities via upregulation of E-cadherin expression levels and downregulation of Vimentin, matrix metalloproteinase (MMP)-2, MMP-9, snail family transcriptional repressor (Snai) 1 and Snai2 expression levels."
30272359
BRCC3 affects SNAI
| 1
BRCC3 inhibits SNAI. 1 / 1
| 1
reach
"Furthermore, BRCC3 interference inhibited the cell viability, invasion and migration abilities of HeLa and SiHa cells via regulation of EMT progression and expression levels of Snai family members."
30272359
BRCC3 affects SMARCD1
1 |
SMARCD1 binds BRCC3. 1 / 1
1 |
biogrid
No evidence text available
26186194
BRCC3 affects SMAD3
| 1
BRCC3 leads to the deubiquitination of SMAD3. 1 / 1
| 1
reach
"BRCC36 may inhibit the activation of the TGF-beta1 signaling pathway by regulating the ubiquitination of smad3."
30834083
BRCC3 affects SLPI
| 1
BRCC3 activates SLPI. 1 / 1
| 1
reach
"Results showed that BRCC3 siRNA induced activation of ALP (XREF_FIG) and promoted the formation of calcified nodules (XREF_FIG)."
30834083
BRCC3 affects SGCG
| 1
BRCC3 deubiquitinates SGCG. 1 / 1
| 1
reach
"Dr. Greenberg group from University of Pennsylvania showed that BRCC36 containing deubiquitinating complex BRISC which is also a sister protein complex of nuclear RAP80-BRCA1 complex, deubiquitinates type I interferon receptor (IFNAR1), resulting in its delayed lysosomal dependent degradation."
27211605
BRCC3 affects SF3A1
1 |
SF3A1 binds BRCC3. 1 / 1
1 |
biogrid
No evidence text available
22863883
BRCC3 affects RPN11
| 1
BRCC3 activates RPN11. 1 / 1
| 1
reach
"Interestingly, MPN- subunits of the 26S proteasome lid and of BRCC36 containing complexes are able to activate their otherwise inactive catalytic subunits, Rpn11 and POH1 and BRCC36, respectively XREF_BIBR."
25144743
BRCC3 affects RP23-244N6.4
1 |
BRCC3 binds RP23-244N6.4. 1 / 1
1 |
biogrid
No evidence text available
26496610
BRCC3 affects RNF213
| 1
BRCC3 decreases the amount of RNF213. 1 / 1
| 1
reach
"Here, we showed that most RNF213- and BRCC3 associated miRNAs were elevated in serum of MMD patients, repressed RNF213 and BRCC3 protein expression in HBMVEC, and modulated HBMVEC angiogenesis."
25093848
BRCC3 affects RABEP2
1 |
BRCC3 binds RABEP2. 1 / 1
1 |
biogrid
No evidence text available
22863883
BRCC3 affects PWWP2B
| 1
BRCC3 binds PWWP2B. 1 / 1
| 1
reach
"BRCC3 interacts and stabilizes HDAC1 or PWWP2B individually (Figure S7c,d, Supporting Information), and the presence of PWWP2B could further augment the BRCC3 interacting with and stabilizing HDAC1 protein (Figure S7c,d, Supporting Information, see the last lane in each Figure)."
34180153
BRCC3 affects PSMD14
| 1
BRCC3 activates PSMD14. 1 / 1
| 1
reach
"Interestingly, MPN- subunits of the 26S proteasome lid and of BRCC36 containing complexes are able to activate their otherwise inactive catalytic subunits, Rpn11 and POH1 and BRCC36, respectively XREF_BIBR."
25144743
BRCC3 affects PRSS27
| 1
PRSS27 binds BRCC3. 1 / 1
| 1
reach
"The MPN + domain protein BRCC36 associates with pseudo-DUB MPN - proteins KIAA0157 or Abraxas, which are essential for BRCC36 enzymatic activity."
26344097
BRCC3 affects PPP4R3A
1 |
PPP4R3A binds BRCC3. 1 / 1
1 |
biogrid
No evidence text available
22863883
BRCC3 affects PAXIP1
1 |
BRCC3 binds PAXIP1. 1 / 1
1 |
biogrid
No evidence text available
22990118
BRCC3 affects OL
| 1
BRCC3 activates OL. 1 / 1
| 1
reach
"In contrast, the knockdown of BRCC3 (BRCC3-KD) through the application of lentivirus mediated shRNA delivery system into OPCs suppressed OL differentiation by decreasing MBP expression and PLP production."
31184779
BRCC3 affects NR3C1
1 |
BRCC3 binds NR3C1. 1 / 1
1 |
biogrid
No evidence text available
22863883
BRCC3 affects NOD
| 1
BRCC3 leads to the deubiquitination of NOD. 1 / 1
| 1
reach
"BRCC3 have been shown to promote the inflammasome activation by deubiquitinating NOD like receptor containing pyrin domain 3 (NLRP3)."
31787240
BRCC3 affects NLRP6
| 1
NLRP6 binds BRCC3. 1 / 1
| 1
reach
"Interestingly, the result of co-immunoprecipitation showed that the interaction between BRCC3 and NLRP6 was enhanced after model, and the result of immunofluorescence showed that the co-localization of BRCC3 and NLRP6 was increased."
33979701
BRCC3 affects NLRP3 inflammasome
| 1
BRCC3 activates NLRP3 inflammasome. 1 / 1
| 1
eidos
"BRCA1-BRCA2-containing complex subunit 3 ( BRCC3 ) , a deubiquitinating enzyme , can deubiquitinate the NLRP3 LRR domain and promote NLRP3 inflammasome activation [ 60 ] ."
35365780
BRCC3 affects NHEJ
| 1
BRCC3 inhibits NHEJ. 1 / 1
| 1
reach
"Depletion of BRCC36 resulted in enhanced DNA-end resection, increased HR and decreased NHEJ efficiency, phenocopying RAP80 depletion [92]."
28764946
BRCC3 affects NDUFA10
1 |
BRCC3 binds NDUFA10. 1 / 1
1 |
biogrid
No evidence text available
19615732
BRCC3 affects MTA2
1 |
BRCC3 binds MTA2. 1 / 1
1 |
biogrid
No evidence text available
22863883
BRCC3 affects MRPL1
1 |
MRPL1 binds BRCC3. 1 / 1
1 |
biogrid
No evidence text available
26496610
BRCC3 affects MRE11
| 1
BRCC3 binds MRE11. 1 / 1
| 1
reach
"MRE11 binds BRCC3, which in turn deubiquitinates γH2AX deposited at exposed telomeric DNA ends and limits RNF168 recruitment to the telomere."
34881184
BRCC3 affects MDC1
1 |
MDC1 binds BRCC3. 1 / 1
1 |
biogrid
No evidence text available
22990118
BRCC3 affects MCM2
1 |
BRCC3 binds MCM2. 1 / 1
1 |
biogrid
No evidence text available
19615732
BRCC3 affects LRR
| 1
BRCC3 ubiquitinates LRR. 1 / 1
| 1
reach
"Notably, G5 dramatically increased BRCC3 binding to high molecular weight ubiquitinated LRR, suggesting that BRCC3 specifically interacts with the ubiquitinated LRR domain."
23246432
BRCC3 affects LARP7
1 |
BRCC3 binds LARP7. 1 / 1
1 |
biogrid
No evidence text available
22863883
BRCC3 affects K48Ub
| 1
BRCC3 activates K48Ub. 1 / 1
| 1
reach
"Importantly, depletion of either BRCC36 or SHMT1 in HeLa cells also selectively increased K63Ub, but not K48Ub, of the FLAG-Tat protein (XREF_FIG)."
29791506
BRCC3 affects JOSD2
| 1
BRCC3 binds JOSD2. 1 / 1
| 1
isi
"This was mediated by enhanced deubiquitination of NLRP3 via binding with deubiquitinases BRCC3 and JOSD2, which are highly expressed in myeloid cells."
32941940
BRCC3 affects JAK2
1 |
BRCC3 deubiquitinates JAK2. 1 / 1
1 |
ubibrowser
"We show here that a LNK-associated lysine-63 (K63)-deubiquitinating enzyme complex, Brcc36 isopeptidase complex (BRISC), attenuates HSC expansion through control of JAK2 signaling."
30755420
BRCC3 affects IL6
| 1
BRCC3 activates IL6. 1 / 1
| 1
reach
"We found that the downregulation of BRCC3 led to a specific and strong blockage of IL-1beta release triggered by ATP, while it had no effect on the NLRP3 independent TNF-alpha and IL-6 secretion induc[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23246432
BRCC3 affects ICAM
| 1
BRCC3 inhibits ICAM. 1 / 1
| 1
reach
"In addition, Real-time PCR analyses indicated that the ablation of BRCC3 reduced the expression of the NF-κB signaling down-stream genes including cIAP2, TNFα, and ICAM (Figure 4F)."
34604222
BRCC3 affects Histone
| 1
BRCC3 deubiquitinates Histone. 1 / 1
| 1
reach
"There are many examples of HDACs being recruited to sites of DNA repair (as discussed above), and the BRCA-1A complex actually contains a DUB, Brcc36, that can deubiquitinate histones at least in vitro."
22249206
BRCC3 affects HUWE1
1 |
BRCC3 binds HUWE1. 1 / 1
1 |
biogrid
No evidence text available
22863883
BRCC3 affects HNRNPR
1 |
BRCC3 binds HNRNPR. 1 / 1
1 |
biogrid
No evidence text available
22863883
BRCC3 affects HBMVEC
| 1
BRCC3 activates HBMVEC. 1 / 1
| 1
reach
"Here, we showed that most RNF213- and BRCC3 associated miRNAs were elevated in serum of MMD patients, repressed RNF213 and BRCC3 protein expression in HBMVEC, and modulated HBMVEC angiogenesis."
25093848
BRCC3 affects H2AC17
1 |
BRCC3 deubiquitinates H2AC17. 1 / 1
1 |
BRCC3 affects Glioma
| 1
BRCC3 activates Glioma. 1 / 1
| 1
reach
"It was shown that the downregulation of BRCC3 expression caused glioma cells to become more sensitive to temozolomide, an alkylating agent[64]."
34457187
BRCC3 affects GST
| 1
GST binds BRCC3. 1 / 1
| 1
reach
"First, endogenous NuMA was immunoprecipitated from mitotic HeLa cells by using anti-NuMA antibody (XREF_FIG), and WT or DUB inactive mutant (QSQ) of GST and BRCC36 complex was purified from Sf9 insect cells (XREF_FIG)."
26195665
BRCC3 affects GRB2
1 |
BRCC3 binds GRB2. 1 / 1
1 |
biogrid
No evidence text available
19380743
BRCC3 affects GPHN
1 |
GPHN binds BRCC3. 1 / 1
1 |
biogrid
No evidence text available
22863883
BRCC3 affects GGN1
| 1
BRCC3 binds GGN1. 1 / 1
| 1
reach
"We demonstrated that the largest isoform GGN1 interacts with DNA repair proteins FANCL, FANCD2 and BRCC36 (BRCA1 and BRCA2 containing complex, subunit 3, alias BRCC3) in the mouse testis."
23451117
BRCC3 affects FLAG-Tat protein
| 1
BRCC3 activates FLAG-Tat protein. 1 / 1
| 1
reach
"Importantly, depletion of either BRCC36 or SHMT1 in HeLa cells also selectively increased K63Ub, but not K48Ub, of the FLAG-Tat protein (XREF_FIG)."
29791506
BRCC3 affects FANCA
1 |
BRCC3 binds FANCA. 1 / 1
1 |
biogrid
No evidence text available
28215707
BRCC3 affects EXOC8
1 |
BRCC3 binds EXOC8. 1 / 1
1 |
biogrid
No evidence text available
19615732
BRCC3 affects ERK
| 1
BRCC3 decreases the amount of phosphorylated ERK. 1 / 1
| 1
reach
"Consistently, BRCC3 siRNA treatment of MDA-MB 231 cells caused decreased expression of BRCC3 and p-ERK."
17143545
BRCC3 affects E2F5
1 |
BRCC3 binds E2F5. 1 / 1
1 |
biogrid
No evidence text available
19615732
BRCC3 affects DSB-associated conjugated ubiquitin
| 1
BRCC3 inhibits DSB-associated conjugated ubiquitin. 1 / 1
| 1
eidos
"Supporting this model , BRCC36 depletion increases DSB-associated conjugated ubiquitin and 53BP1 accumulation at DSB sites [ 189 ] ."
21056014
BRCC3 affects DSB-associated K63-Ub [
| 1
BRCC3 inhibits DSB-associated K63-Ub [. 1 / 1
| 1
reach
"Interestingly, the RAP80 complex also contains BRCA and BRCA2 containing complex subunit 36 (BRCC36), a deubiquitylating enzyme that specifically hydrolyzes K63-Ub chains, thus limiting the accumulation of DSB associated K63-Ub [XREF_BIBR, XREF_BIBR]."
22836122
BRCC3 affects DDSB site
| 1
BRCC3 binds DDSB site. 1 / 1
| 1
reach
"Alongside the E3 activity of BRCA1, the BRCA1 A-complex anchoring to the DDSB site binds BRCC36 deubiquitinylase [46]."
23416467
BRCC3 affects DDOST
1 |
BRCC3 binds DDOST. 1 / 1
1 |
biogrid
No evidence text available
19615732
BRCC3 affects CENPA
1 |
CENPA binds BRCC3. 1 / 1
1 |
biogrid
No evidence text available
26496610
BRCC3 affects CDK5
| 1
CDK5 binds BRCC3. 1 / 1
| 1
reach
"The interaction between Cdk5 and BRCC3 was further confirmed by immunoprecipitation."
31787240
BRCC3 affects CDC25A
| 1
CDC25A binds BRCC3. 1 / 1
| 1
reach
"Furthermore, we failed to detect any interaction between BRCC36 and CDC25A making it unlikely to be involved in CDC25A regulation."
29416040
BRCC3 affects CD2AP
1 |
CD2AP binds BRCC3. 1 / 1
1 |
biogrid
No evidence text available
22863883
BRCC3 affects CCDC6
1 |
CCDC6 binds BRCC3. 1 / 1
1 |
biogrid
No evidence text available
22863883
BRCC3 affects CAND1
1 |
BRCC3 binds CAND1. 1 / 1
1 |
biogrid
No evidence text available
19615732
BRCC3 affects BRCC
| 1
BRCC3 inhibits BRCC. 1 / 1
| 1
reach
"From these results, BRCC36 overexpression like C-terminal truncation of BRCA1 may disrupt the normal function of the BRCC complex in the DNA damage response pathway, thereby accelerating breast tumor [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16854521
BRCC3 affects BRCA1/BRCA2-containing
| 1
BRCA1/BRCA2-containing binds BRCC3. 1 / 1
| 1
isi
"Mechanism study revealed that celastrol could interdict K63 deubiquitination of NLRP3, which may concern interaction of celastrol and BRCA1/BRCA2-containing complex subunit 3 (BRCC3), and thereby prohibited the formation of NLRP3, ASC and pro-caspase-1 complex to block the generation of mature IL-1beta."
33130474
BRCC3 affects BRCA1-BARD1
| 1
BRCC3 bound to BABAM2 activates BRCA1-BARD1. 1 / 1
| 1
reach
"The interaction between BRE and BRCC36 has been reported to enhance the E3 ligase activity of BRCA1-BARD1 in a BRCC complex XREF_BIBR."
27001068
BRCC3 affects BIRC3
| 1
BRCC3 inhibits BIRC3. 1 / 1
| 1
reach
"In addition, Real-time PCR analyses indicated that the ablation of BRCC3 reduced the expression of the NF-κB signaling down-stream genes including cIAP2, TNFα, and ICAM (Figure 4F)."
34604222
BRCC3 affects BACH1
1 |
BRCC3 binds BACH1. 1 / 1
1 |
biogrid
No evidence text available
17664283
BRCC3 affects ATP5PO
1 |
BRCC3 binds ATP5PO. 1 / 1
1 |
biogrid
No evidence text available
19615732
BRCC3 affects ATP-induced secretion mature IL-1beta
| 1
BRCC3 activates ATP-induced secretion mature IL-1beta. 1 / 1
| 1
eidos
"Furthermore , BRCC3 knockdown was shown to reduce the ATP-induced secretion of mature IL-1beta by in macrophages ( 91 ) ."
33603747
BRCC3 affects ANRIL
| 1
BRCC3 binds ANRIL. 1 / 1
| 1
reach
"The interaction between ANRIL, miR-122-5p and BRCC3 were studied using luciferase reporter assay."
30347231
BRCC3 affects 63
| 1
BRCC3 binds UIMC1 and 63. 1 / 1
| 1
reach
"The Rap80 and Brcc36 complex furthermore removes lysine 63 linked polyubiquitin chains from the chromatin and is thus also involved in the termination of RNF8-Ubc13-mediated polyubiquitination once the lesion has been repaired [XREF_BIBR]."
21037856
BRCC3 affects 53BP1 accumulation
| 1
BRCC3 inhibits 53BP1 accumulation. 1 / 1
| 1
eidos
"Supporting this model , BRCC36 depletion increases DSB-associated conjugated ubiquitin and 53BP1 accumulation at DSB sites [ 189 ] ."
21056014
BRCC3 affects 5-fluorouracil
| 1
reach
"In 2016, Sun et al[62] reported in their in vitro study that overexpression of B7-H3 upregulates BRCA1/BRCA2-containing complex subunit 3 (BRCC3) expression and antagonizes the anticancer activity of 5-fluorouracil (5-FU)."
34457187
BRCA1/BRCA2-containing affects BRCC3
| 1
BRCA1/BRCA2-containing binds BRCC3. 1 / 1
| 1
isi
"Mechanism study revealed that celastrol could interdict K63 deubiquitination of NLRP3, which may concern interaction of celastrol and BRCA1/BRCA2-containing complex subunit 3 (BRCC3), and thereby prohibited the formation of NLRP3, ASC and pro-caspase-1 complex to block the generation of mature IL-1beta."
33130474
BRCA1 affects ABRAXAS1
| 1
reach
"As discussed in Section 5.7, SUMOylation of BRCA1 is a prerequisite for BRCA1 's efficient in vitro and in vivo ubiquitylation activity [602,603], and autoubiquitylation [1038,1039] may promote this a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22743550
BMP2 affects BRCC3
| 1
BMP2 activates BRCC3. 1 / 1
| 1
reach
"Our research found that BRCC36 aggravated intestinal mucosal barrier injury caused by BMP2 (Bone morphogenetic protein 2) after I/R by downregulating PPARγ (Peroxisome proliferator-activated receptor-γ) signaling."
34888627
BARD1 affects UIMC1
| 1
reach
"As discussed in Section 5.7, SUMOylation of BRCA1 is a prerequisite for BRCA1 's efficient in vitro and in vivo ubiquitylation activity [602,603], and autoubiquitylation [1038,1039] may promote this a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22743550
BACH1 affects BRCC3
1 |
BRCC3 binds BACH1. 1 / 1
1 |
biogrid
No evidence text available
17664283
Abraxas affects BRCC3, and UIMC1
| 1
BRCC3 binds UIMC1 and Abraxas. 1 / 1
| 1
reach
"In the proteomic analysis they performed they identified and confirmed that BRCC45 (BRE) and MERIT40 (Hspc142) are also part of this complex and that this heterodimer is responsible for the integrity of the Abraxas, Rap80, and BRCC36 complex [XREF_BIBR]."
24832651
ATP5PO affects BRCC3
1 |
BRCC3 binds ATP5PO. 1 / 1
1 |
biogrid
No evidence text available
19615732
ABRAXAS1 affects UIMC1
| 1
reach
"As discussed in Section 5.7, SUMOylation of BRCA1 is a prerequisite for BRCA1 's efficient in vitro and in vivo ubiquitylation activity [602,603], and autoubiquitylation [1038,1039] may promote this a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22743550
63 affects UIMC1
| 1
BRCC3 binds UIMC1 and 63. 1 / 1
| 1
reach
"The Rap80 and Brcc36 complex furthermore removes lysine 63 linked polyubiquitin chains from the chromatin and is thus also involved in the termination of RNF8-Ubc13-mediated polyubiquitination once the lesion has been repaired [XREF_BIBR]."
21037856
2,3,7,8-tetrachlorodibenzodioxine increases the amount of BRCC3. 1 / 1
1 |
ctd
No evidence text available
19465110
17alpha-ethynylestradiol decreases the amount of BRCC3. 1 / 1
1 |
ctd
No evidence text available
23129252
1,2-dithiol-3-thione decreases the amount of BRCC3. 1 / 1
1 |
ctd
No evidence text available
19162173
(S)-carnitine affects BRCC3
| 1
reach
"Anti-oxidants L-carnitine and NAC significantly suppress ROS overproduction and BRCC36 production, block caspase-8 activation, and largely reverse or restore the imbalance of activated NLRP3 and suppressed NLRP6."
28238526
(+)-catechin affects BRCC3
1 |
(+)-catechin decreases the amount of BRCC3. 1 / 1
1 |
ctd
No evidence text available
15465739
3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid decreases the amount of BRCC3. 1 / 1
1 |
ctd
No evidence text available
16788091
3,4,3',4'-tetrachlorobiphenyl increases the amount of BRCC3. 1 / 1
1 |
ctd
No evidence text available
19467301