IndraLab

Statements

BRCC3 activates DNA repair. 3 / 5
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"B7-H3 upregulated BRCC3 expression, enhancing DNA repair in CRC cells and BRCC3 may play a role in B7-H3-induced 5-Fu resistance [88] ."
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"Thus, the inhibition of BRCC3 expression may impair DNA repair mechanism in U251 and A172 cells, which can promotes sensitization of the two glioma cell lines to TMZ."
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"Altogether, results suggest that BRCC3 may play a role in B7-H3-induced 5-Fu resistance, such that B7-H3 upregulates BRCC3 expression, enhancing DNA repair in colorectal cancer cells."
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