IndraLab

Statements

BRCA1 binds BRCC3, BARD1, and Abraxas. 3 / 3
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"Interactions of Abraxas, BACH1 and CtIP with the BRCT domain of BRCA1 are mutually exclusive, suggesting that the three proteins compete for the same binding site to form distinct BRCA1 containing complexes, of which only the Abraxas, BRCC36, BRCA1, and BARD1 complex is recruited to sites of DNA damage by RAP80 [XREF_BIBR]."
19473884
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"Receptor associated protein 80 (RAP80) plays a key role in recruiting the Abraxas, BRCC36, BRCA1, and BARD1 complex to DNA damage foci for DNA repair by possessing an Abraxas interacting region."
20357899
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"RAP80 has a key role in the recruitment of the Abraxas, BRCC36, BRCA1, and BARD1 complex to DNA-damage foci for DNA repair through specific recognition of Lys 63 linked polyubiquitinated proteins by its tandem ubiquitin interacting motifs (UIMs)."
19536136