IndraLab
Statements
reach
"BRCA1 binds with its BRCT domain to phosphorylated ABRA1, which acts as a scaffold and binds BRCC36 (BRCA1 and BRCA2 containing complex subunit 36, also known as BRCC3), a deubiquitinating enzyme, BRCC45 (BRCA1 and BRCA2 containing complex subunit 45, also known as BRE), and RAP80, which is essential for the recruitment of BRCA1."
reach
"Conversely, one may conclude that an increase of K63 linked ubiquitin conjugation by other means, such as treatments that increase nuclear Ubc13 function or by interference with the competing ubiquitin hydrolase complex Rap80 and BRCC36, may shift the balance in favour of exactly those processes that are most sensitive to gradual interference with Ubc13 levels."