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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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Statements

BRCC3 activates deubiquitinate NLRP3. 1 / 1

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eidos

"There are two key steps between NLRP3 activation and inflammation : firstly priming , in which stimuli activate NF-kappaB signaling via Toll-like receptors , IL-1 receptors , TNFR1 and TNFR2 ; NF-kappaB improves the level of transcription of pro-IL-1beta , pro-IL-18 , and NLRP3 , and secondly , activation , in which DAMPs and other stimuli promote inflammasome assembly via activating BRCC3 to deubiquitinate NLRP3 [ 134 ] ."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...