IndraLab

Statements

BRCA1 binds BRCC3. 19 / 22
8 1 | 1 9
reach
"Mutations that abolish the interaction between BRCA1 and BRCC36 reduce the association of BRCA2 and RAD51 to the complex, whereas mutations that abolish BARD1 interaction with BRCA1 had no effect on the association of the above proteins [XREF_BIBR]."
24832651
biogrid
No evidence text available
25184681
biogrid
No evidence text available
14636569
biogrid
No evidence text available
25252691
hprd
No evidence text available
14636569
reach
"BRCC3 directly interacts with BRCA1 at the region encompassing amino acids 502 to 1054 [XREF_BIBR], which falls within the BRCA1 DNA binding domain (amino acids 452-1079)."
26024915
reach
"Together these data indicate a direct interaction of BRCA1 and BRCC36 which is lost following cancer causing truncations of BRCA1.To directly address the role of BRE and BRCC36 in BRCC 's ubiquitin E3[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
14636569
reach
"BRCC36, one of the proteins in BRCC, directly interacts with BRCA1, and regulates the ubiquitin E3 ligase activity of BRCC."
16707425
reach
"The deubiquitinase BRCA1-BRCA2-containing complex subunit 3 (BRCC3)-mediated nucleotide-binding domain and leucine-rich repeat receptor containing a pyrin domain 3 (NLRP3) inflammasome activation participates in this progress."
34874278
trips
"Abraxas mainly localizes in the nucleus, mediating the interaction of BRCC36 with BRCA1."
21282113
biogrid
No evidence text available
14636569
reach
"These results correlate the loss of function of truncated BRCA1 protein with the loss of several key regulatory components of BRCC.To determine whether BRCC36 can directly interact with BRCA1, six fra[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
14636569
biogrid
No evidence text available
19305427
biogrid
No evidence text available
22990118
reach
"Here we demonstrate that the model plant Arabidopsis thaliana harbors two homologs of the mammalian BRCA1 interaction partner BRCC36, AtBRCC36A and AtBRCC36B."
20817926
biogrid
No evidence text available
14636569
reach
"MERIT40 appears to control the cell cycle checkpoint and resistance to DNA damaging agents by mediating interactions between the core BRCA1 and RAP80 complex and BRCC36, thus targeting lysine-63-ubiquitin (K63-Ub) deubiquitination activity to DNA damage sites [XREF_BIBR - XREF_BIBR]."
19572197
biogrid
No evidence text available
17664283
reach
"BRCA1 also forms a complex with RAP80, Abraxas, BRCA1 and BRCA2 containing complex subunit 36 (BRCC36), BRCC45 and mediator of RAP80 interactions and targeting subunit of 40 kDa (MERIT40) [XREF_BIBR - XREF_BIBR]."
26983989