IndraLab

Statements

TCHH inhibits BRCC3. 4 / 4
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"50 BRCC36 overexpression upregulates GSDMD expression and induces chronic pyroptosis, both of which deteriorate the tumor microenvironment (TME) over time and accelerate tumor growth, but this needs to be further studied.Furthermore, THL could inhibit the activity of the BRCC36 enzyme, reduce HMGCR protein levels, and suppress tumor growth."
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"These findings suggest that the inhibition of BRCC36 by THL provides a novel and effective therapeutic approach for liver cancer treatment by promoting ferroptosis."
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"We then explored whether THL could inhibit the deubiquitinase activity of BRCC36 against HMGCR."
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"Thiolutin also inhibits the JAMM metalloproteases Csn5, the deneddylase of the COP9 signalosome, Associated-molecule-with-the-SH3-Domain-of-STAM (AMSH), which regulates ubiquitin dependent sorting of cell-surface receptors, and Brcc36, a K63 specific deubiquitnase of BRCC36 containing isopeptidase complex (BRISC) and BRCA1, BRCA2, and containing complex (BRCC)."
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