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BRCC3 leads to the deubiquitination of NACHT. 1 / 1
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"Recently, Py and colleagues demonstrated that BRCC3, a JAMM domain containing zinc metalloprotease DUB, promotes NLRP3 inflammasome activation by deubiquitinating the mixed K64 and K48 ubiquitin chains on both the NACHT and LRR domains of NLRP3 [XREF_BIBR]."