IndraLab

Statements


BRCC3 increases the amount of CTNNB1. 3 / 3
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"Depletion of BRCC3 promoted the activation of alkaline phosphatase and formation of calcified nodules in osteoblasts isolated from osteoporosis patients and up-regulated beta-catenin expression."

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"Consistently, depletion of BRCC3 increased the level of beta-catenin and promoted osteogenic differentiation, and inhibitor XAV939 inhibited the BRCC3 induced osteogenic differentiation."

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"Interestingly, we revealed that BRCC36 knockdown decreased beta-catenin expression in CRC cells, suggesting that binding between SHMT2 and BRCC36 may direct BRCC36 activity towards K63-Ub chains conjugated to beta-catenin in CRC cells."