IndraLab

Statements


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"Knockdown of BRCC3 increased the cell survival fraction, attenuated DNA damage repair and resulted in G2/M cell cycle arrest in radioresistant NPC cells."

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"Our data showed that BRCC3 gene knockdown reduced the cell viability of TMZ treated U251 and A172 cells when compared to the relative TMZ treated mock cells."

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"Since BRCC 3 is one of most regulated molecules by miR-US25-1, we speculated that the cell viability reduction might be caused by the BRCC 3 blockage."

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"The inhibition of BRCC3 gene expression significantly reduces the cell viability and clonogenicity of U251 and A172 cells by TMZ treatment, indicating that BRCC3 can be treated as the target in order to enhance the sensitivity of glioma cells to TMZ."