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BRCC3 activates deubiquitination such modification. 1 / 1
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eidos
"TLR and ROS signaling can increase the levels of NLRP3 via BRCA1 / BRCA2-containing complex subunit 3 ( BRCC3 ) which mediates deubiquitination of the LRR domain of NLRP3 and such modification is essential for its activation ( Py et al ., 2013 ) ."