IndraLab

Statements

BRCC3 inhibits DNA Damage. 4 / 4
| 4
reach
"B7-H3 upregulates BRCC3 expression, antagonizing DNA damage caused by 5-Fu."
27175567
reach
"Knockdown of BRCC3 increased the cell survival fraction, attenuated DNA damage repair and resulted in G2/M cell cycle arrest in radioresistant NPC cells."
26024915
reach
"In addition, a few other mechanisms may also underlie B7H3 mediated chemoresistance : (1) B7H3 induces oxaliplatin resistance by increasing the expression of XRCC1 via PI3K and AKT pathway; (2) B7H3 also enhances cell resistance to chemotherapy by increasing the expression of BRCC3, which antagonizes DNA damage caused by 5-FU; (3) or via the activation of the PI3K and AKT pathway."
30035102
reach
"Moreover, B7-H3 could upregulate BRCC3 or XRCC1 expression to antagonize DNA damage caused by 5-FU or L-OHP in CRC XREF_BIBR, XREF_BIBR."
32127943