IndraLab

Statements


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"BRCA1 encodes a protein forming the Rap80, Abraxas, Brca1, and Brcc36 complex in response to DNA damage XREF_BIBR."

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"UBC13 and RNF8 ubiquitin ligases control focus formation of the Rap80, Abraxas, Brca1, and Brcc36 complex in response to DNA damage."

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"It was proposed that the role of the BRCA1, Abraxas, RAP80, and BRCC36 complex is to limit DSB resection."

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"This activity and histone modification is required for the recruitment of other DDR proteins, specifically 53BP1 and the Rap80, Abraxas, Brca1, and Brcc36 complex to DSBs [167,168]."

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"Ubc13 and Rnf8 ubiquitin ligases control foci formation of the Rap80, Abraxas, Brca1, and Brcc36 complex in response to DNA damage."

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"Recruitment of the 53BP1 and Rif1 complex to DSBs promotes NHEJ repair and prevents the HR promoting BRCA1 and CtIP complex from binding to DSB sites (Chapman et al., 2013; Di Virgilio et al., 2013; F[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"