IndraLab

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BRCC3 activates NLRP3. 12 / 12
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"Here, we also obtained consistent results with shRNA-BRCC3 lentivirus in the MPP + -induced PD model, demonstrated that inhibiting BRCC3 obviously attenuates NLRP3 inflammasome.The NLRP3 inflammasome [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"A study found that BRCC3 expression is increased in PD models, whereas knocking it down with shRNA lentivirus decreases the NLRP3 inflammasome activity."
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"Thus, BRCC3 may contribute to regulating the NLRP3 inflammasome in PD [72]."
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"The authors further suggested that the deubiquitylation of NLRP3 was critical for the inflammasome activation based on the facts that inhibiting BRCC3 could abolish NLRP3 inflammasome activation under a diverse range of classic " activation signals, " including K + efflux, ROS overproduction, and lysosomal destabilization."
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"Deficiency of either the catalytic subunit BRCC3 or the scaffold subunit ABRO1 blocks NLRP3 activation in both mouse and human macrophages ."
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"Regulation of oxidized LDL induced inflammatory process through NLRP3 inflammasome activation by the deubiquitinating enzyme BRCC36."
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"BRCC3, a deubiquitinase for NLRP3, increases NLRP3 activation through the removal of ubiquitin chains from NLRP3 [84, 85]."
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"Deubiquitinase BRCC3 enhances NLRP3 activation via cleaving the ubiquitin chains of NLRP3 [26]."
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"Moreover, inhibition of BRCC3 reduces neuronal NLRP3 inflammasome in PD model induced by MPP + ."
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"Our collective data supported the requirement of the VDR‐BRCC3 signaling pathway for VD3‐induced inactivation of the NLRP3 inflammasome and subsequent inhibition of hyperinflammation in HBE‐N cells.2.4 VD3 attenuated N protein-induced hyperinflammation by inactivating the NLRP3 inflammasome through the VDR-BRCC3 signaling pathway in vivo."
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"Deubiquitination of NLRP3 by the BRCA1 / BRCA2 containing complex subunit 3 (BRCC3) promoted NLRP3 inflammasome activity by preventing its degradation 39."
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"Moreover, USP7, USP47, and BRCC3 and ABRO can activate the NLRP3 inflammasome."
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