IndraLab

Statements

BRCC3 activates NLRP3. 5 / 5
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"Regulation of oxidized LDL induced inflammatory process through NLRP3 inflammasome activation by the deubiquitinating enzyme BRCC36."
31485755
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"The authors further suggested that the deubiquitylation of NLRP3 was critical for the inflammasome activation based on the facts that inhibiting BRCC3 could abolish NLRP3 inflammasome activation under a diverse range of classic " activation signals, " including K + efflux, ROS overproduction, and lysosomal destabilization."
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"Moreover, USP7, USP47, and BRCC3 and ABRO can activate the NLRP3 inflammasome."
32850399
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"The BRCC3 regulated by Cdk5 promotes the activation of neuronal NLRP3 inflammasome in Parkinson 's disease models."
31787240
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"Deubiquitination of NLRP3 by the BRCA1 / BRCA2 containing complex subunit 3 (BRCC3) promoted NLRP3 inflammasome activity by preventing its degradation 39."
32424362