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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

BRCC3 ubiquitinates NLRP3. 3 / 3

1 | 2

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bel

" NLRP3 deubiquitylation is mediated by the K63-specific deubiquitinase BRCC3 (REF. 63)."

23702978

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reach

"Previous reports have described TRIM31, FBXL2, and MARCH7 to promote ubiquitination and degradation of NLRP3 XREF_BIBR - XREF_BIBR with de-ubiquitination by the BRCC3 complex facilitating activation of NLRP3 XREF_BIBR - XREF_BIBR."

29674674

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reach

"SYVN1-mediated BRCC3 down-regulation promoted NLRP3 ubiquitination and reduced pro-inflammatory cytokine secretion."

34874278

Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...