IndraLab

Statements

BRCC3 activates CASP1. 4 / 4
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"Since transduction of wild-type BRCC3, but not of the inactive mutant BRCC3 H122Q, rescued caspase-1 cleavage and IL-1beta secretion inhibited by BRCC3 KD, we conclude that BRCC3 regulates NLRP3 throu[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In addition, BRCC3 knockdown inhibited NLRP3 dependent, TLR independent cleaved caspase-1 secretion triggered by ATP in NG5 cells."
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"Particularly, Benedicte et al. found that, knockdown of BRCC3 (a component of the BRISC complex) completely inhibited caspase-1 cleavage and IL-1beta secretion."
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"Therefore, we conclude that BRCC3 might be involved in regulating deubiquitination of NLRP3.Consistent with an activator of NLRP3 activity, knockdown of BRCC3 inhibited mature IL-1beta and activated c[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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