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BRCC3 deubiquitinates NLRP3. 33 / 33
| 33
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"Lys-63-specific deubiquitinase BRCC36 (BRCC3), a JAMM domain containing Zn 2+ metalloprotease, promotes NLRP3 deubiquitination during priming and regulates NLRP3 activation [26]."
27669650
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"Viral RNA (vRNA) molecule-induced NLRP3 inflammasome activation also comes about by post-translational priming, but involving the RIP1/caspase 8/RIP3 signaling pathway (29, 45), which may ultimately result in the deubiquitination of NLRP3 protein by BRCC3 (46, 47)."
29163496
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"The K-63-specific deubiquitinating enzyme BRCC3 mediates the deubiquitylation of NLRP3, which has recently been shown to occur in response to pattern recognition receptor stimulation [XREF_BIBR]."
29120406
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"BRCC3 inhibition promotes NLRP3 ubiquitination and blocks inflammasome assembly but does not target NLRP3 for degradation."
30288079
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"By screening a deubiquitinating enzyme (DUB) library, they recognized that BRCC3 (BRCA1, BRCA2, and containing complex subunit 3) deubiquitinates the LRR domain of NLRP3, which then proceeds NLRP3 activation 59."
30755589
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"A posttranscriptional modification, such as NLRP3 deubiquitination mediated by BRCA1/BRCA2-containing complex subunit 3 (BRCC3), is required for NLRP3 activation (signal 2) [67, 68]."
31687078
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"For example, breast cancer 1 (BRCA1)/breast cancer 2 (BRCA2)-containing complex subunit 3 (BRCC3) deubiquitinates NLRP3, and pharmaceutical inhibition of DUBs restricts inflammasome activation [79,112,113], whereas E3 ubiquitin ligases LUBAC and TRIM33 promote inflammasome assembly [114,115]."
27783058
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"Py et al. found that BRCC3 promotes NLRP3 inflammasome activation by deubiquitinating the LRR domain of NLRP3 50."
25762778
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"Recently, BRCC3 in the cytosol has been reported to promote the inflammasome activation by deubiquitinating NLRP3 in LPS primed macrophages [XREF_BIBR]."
25337721
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"A subsequent study identified that the deubiquitinating enzyme, BRCC3, mediates the deubiquitination of NLRP3 [27]."
32545355
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"Inhibition of CD82 improves colitis by increasing NLRP3 deubiquitination by BRCC3."
36600050
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"The mechanism behind this observation is likely TLR4-MyD88-dependent deubiquitination of NLRP3 by BRCC3, which is essential for its activation."
24367371
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"Altogether, these results demonstrate that BRCC3 mediates the deubiquitination of the LRR domain of NLRP3, an important regulatory mechanism in the activation of NLRP3 inflammasome by its cognate stim[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23246432
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"BRCC3, a JAMM domain containing Zn2+ metalloprotease, promotes NLRP3 deubiquitination during priming and regulates NLRP3 activation [XREF_BIBR]."
27669650
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"Moreover, BRCC3 [18], STING [19] and ABRO1 [20] can be activated by NLRP3 agonists, such as ATP, to promote the deubiquitination and sensitivity of NLRP3."
| PMC
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"A previous study has demonstrated that BRCC3, a K63 specific deubiquitinase, enhances NLRP3 inflammasome activity by deubiquitinating NLRP3 35."
30315153
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"NLRP3 deubiquitination is mediated by BRCC3, a member of JAMM domain containing Zn 2+ metalloprotease deubiquitinating enzyme family, therefore providing a novel therapeutic target for IL-1beta-associated inflammatory diseases."
24054327
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"For example, breast cancer 1 (BRCA1)/breast cancer 2 (BRCA2) and containing complex subunit 3 (BRCC3) deubiquitinates NLRP3, and pharmaceutical inhibition of DUBs restricts inflammasome activation [XREF_BIBR, XREF_BIBR, XREF_BIBR], whereas E3 ubiquitin ligases LUBAC and TRIM33 promote inflammasome assembly [XREF_BIBR, XREF_BIBR]."
27783058
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"Deubiquitination of NLRP3 by BRCC3 critically regulates inflammasome activity."
23246432
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"For example, deubiquitination of the LRR domain of NLRP3 by BRCC3, a JAMM domain containing Zn 2+ metalloprotease deubiquitinating enzyme, leads to activation of the inflammasome."
25879280
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"For instance, ubiquitination of NLRP3 by FBXL12, TRIM1, ARIH2 or the dopamine induced E3 ligase MARCH7 promotes the proteasomal degradation of NLRP3 in resting macrophages, whereas deubiquitylation of NLRP3 LRR domain on K63 by BRCC3 triggers ASC oligomerization and inflammasome activation (XREF_FIG)."
33716981
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"BRCA1-BRCA2-containing complex subunit 3 (BRCC3), a deubiquitinating enzyme, can deubiquitinate the NLRP3 LRR domain and promote NLRP3 inflammasome activation [60] ."
35365780
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"Besides phosphorylation, the deubiquitinating enzyme BRCA1/BRCA2-containing complex subunit 3 (BRCC3) promotes an inflammasome activation by deubiquitinating NLRP3 at its LRR domain153."
32550001
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"It has been reported that deubiquitination of NLRP3, mediated by a DUB BRCC3, is a required step for activation of the NLRP3 inflammasome."
26620909
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"In addition, NLRP3-NEK7 binding is also essential for NLRP3 deubiquitination by BRCC3 and subsequently inflammasome assembly, with NLRP3 phosphomimetic mutants showing enhanced ubiquitination and degradation than wildtype NLRP3."
34615873
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"Moreover, BRCC3 knockdown induced ubiquitination of Flag-NLRP3 in NG5 cells and of endogenous NLRP3 in LPS primed inflammatory peritoneal macrophages."
23246432
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"The deubiquitination of NLRP3 by the BRCC3 complex is required for NLRP3 activation, and the K63 linked ubiquitination of ASC targets the AIM2-ASC inflammasome complex for destruction in autophagosomes."
24958845
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"To identify the DUB associated with NALP7, we over-expressed plasmids expressing several candidate DUBs including BRCC3, which deubiquitinates NALP3, COPS5, STAMBPL1, USP7 and the endosome associated DUBs, STAMBP and USP8."
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"Knockdown of the deubiquitinase BRCC3 increases NLRP3 ubiquitination and inhibits inflammasome activity (25), opposite of our observed phenotype with STAMBP knockout."
33253913
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"NLRP3 deubiquitylation is mediated by the K63 specific deubiquitinase BRCC3."
23702978
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"TLR and ROS signaling can increase the levels of NLRP3 via BRCA1/BRCA2-containing complex subunit 3 (BRCC3) which mediates deubiquitination of the LRR domain of NLRP3 and such modification is essential for its activation (Py et al., 2013)."
30405440
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"The deubiquitination of NLRP3 by the BRCC3 complex is required for NLRP3 inflammasome activation XREF_BIBR XREF_BIBR XREF_BIBR."
27929086
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"Song et al. found that NLRP3 S194 phosphorylation promotes its interaction with the deubiquitinase BRCC3, which in turn induces the deubiquitination of NLRP3 and its subsequent activation."
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