IndraLab

"RAP80 facilitates the recruitment of the BRCA1, BARD1, Abraxas, CCDC98, MERIT, and BRCC36 complex to IRIF."

"Receptor associated protein 80 (RAP80 or UIMC1) is an ubiquitin interaction motif containing (UIMC) nuclear protein that facilitates the recruitment of the BRCA1, BARD1, Abraxas, CCDC98, MERIT, and BRCC36 complex to DNA damage sites, which initiates DDR.6, 7, 8, 9, 10, 11, 12, 13 Although previous studies indicate that defective RAP80 function and expression could lead to genomic instability and subsequent increased early stage cancer risk,14, 15, 16 the possible role of RAP80 on tumor progression and malignancy in later stages, including EMT derived metastasis, has not been investigated."