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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

BRCC3 bound to BRISC deubiquitase activates K63Ub. 1 / 1

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"Although Sagnier et al. [XREF_BIBR] suggested that autophagy selectively degrades HIV-1 Tat through a ubiquitin independent interaction with SQSTM1, Xu et al. demonstrated that HIV-1 Tat undergoes K63 polyubiquitination, a mark recognised by SQSTM1 and the NBR1 autophagy cargo receptor [XREF_BIBR, XREF_BIBR, XREF_BIBR], complexes with the CMA specific chaperone HSPA8 and is subjected to K63Ub selective autophagy mediated by serine hydroxymethyltransferase (SHMT) 1, SHMT2 and the BRCC36 and BRISC deubiquitase complex [XREF_BIBR]."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...