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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

SHMT2 activates BRCC3. 2 / 2

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"Cytosolic SHMT2 was known to direct the BRCC36 containing complex (BRISC, a complex with deubiquitination activity) to deubiquitinate type I IFN receptor chain 1 (IFNalphaR1) and thus decrease the internalization and increase the stability of IFNalphaR1."

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"Cytoplasmic SHMT2 directs BRCC36 isopeptidase complex (BRISC) activity at K63-Ub chains combined with the type 1 interferon receptor chain 1 (IFNAR1)."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...