IndraLab

Statements

TRIM14 binds USP14 and BRCC3. 4 / 4
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"The TRIM14-USP14-BRCC3 complex epigenetically regulates inflammation through inhibiting OPTN-mediated autophagic degradation of KDM4D."
35311471
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"The TRIM14-USP14-BRCC3 complex epigenetically regulates inflammation through inhibiting OPTN-mediated autophagic degradation of KDM4D."
35311471
reach
"The TRIM14-USP14-BRCC3 complex inhibits OPTN-mediated autophagic degradation of KDM4D by reducing K63 ubiquitination on KDM4D, thereby removing the H3K9me3 modification from the promoters of IL-12 and IL-23, promoting the expression of the pro-inflammatory cytokines IL-12 and IL-23, and enhancing the inflammatory response [158]."
39806430
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"Additionally, the TRIM14-USP14-BRCC3 complex has been reported to alleviate inflammation by stabilizing KDM4D and preventing its degradation."
40200729