IndraLab

Statements

BRCC3 activates cell differentiation. 6 / 6
| 6
reach
"XAV939 reversed the BRCC3 siRNA induced osteogenic differentiation."
30834083
reach
"BRCC3 siRNA promoted differentiation of osteoblasts and up-regulated beta-catenin After transfected with BRCC3 siRNA and cultured for 21 days, the cells were stained with ALP and ARS (XREF_FIG)."
30834083
reach
"Results showed that XAV939 inhibited the ALP activation and formation of calcified nodules induced by BRCC3 siRNA, suggesting that beta-catenin signaling mediated the BRCC3 siRNA induced osteogenic differentiation (XREF_FIG)."
30834083
reach
"Moreover, depletion of BRCC3 promoted osteogenic differentiation of osteoblast through up-regulated beta-catenin expression, whereas opposite effects were observed after BRCC3 overexpression."
30834083
reach
"In this study, we found depletion of BRCC36 promoted the differentiation and activation of osteoblast, and beta-catenin mediated this effect."
30834083
reach
"In contrast, the knockdown of BRCC3 (BRCC3-KD) through the application of lentivirus mediated shRNA delivery system into OPCs suppressed OL differentiation by decreasing MBP expression and PLP production."
31184779