IndraLab

Statements

BRCC3 activates cell differentiation. 6 / 6
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"In contrast, the knockdown of BRCC3 (BRCC3-KD) through the application of lentivirus mediated shRNA delivery system into OPCs suppressed OL differentiation by decreasing MBP expression and PLP production."
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"Results showed that XAV939 inhibited the ALP activation and formation of calcified nodules induced by BRCC3 siRNA, suggesting that beta-catenin signaling mediated the BRCC3 siRNA induced osteogenic differentiation (XREF_FIG)."
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"In this study, we found depletion of BRCC36 promoted the differentiation and activation of osteoblast, and beta-catenin mediated this effect."
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"BRCC3 siRNA promoted differentiation of osteoblasts and up-regulated beta-catenin After transfected with BRCC3 siRNA and cultured for 21 days, the cells were stained with ALP and ARS (XREF_FIG)."
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"Moreover, depletion of BRCC3 promoted osteogenic differentiation of osteoblast through up-regulated beta-catenin expression, whereas opposite effects were observed after BRCC3 overexpression."
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"XAV939 reversed the BRCC3 siRNA induced osteogenic differentiation."
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