IndraLab

Statements


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"The co‐IP analysis revealed that inhibiting BRCC36 with the inhibitor or siRNA induced an increase in K63‐Ub chains in ITD cells compared to control cells, while no significant changes were observed in TKD cells (Figure 5E)."

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"Co-depletion of POH1 and RAP80, BRCC36 or ABRAXAS allows establishment of the 53BP1 and ubiquitin chain-devoid core."

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"However, interestingly, inhibition of RAP80, in addition to BRCC36, a DUB subunit in BRCA1-A complex, remarkably enhances the accumulation of conjugated ubiquitin at DSBs [75] ."