IndraLab

Statements


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"SHMT2 reportedly binds to BRCC36 and acts as an apparent competitive inhibitor for BRCC36 XREF_BIBR."

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"Interestingly, we revealed that BRCC36 knockdown decreased beta-catenin expression in CRC cells, suggesting that binding between SHMT2 and BRCC36 may direct BRCC36 activity towards K63-Ub chains conjugated to beta-catenin in CRC cells."

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"Given that SHMT2 and BRCC36 complexes work together to promote K-63 ubiquitin deubiquitination XREF_BIBR, we investigated whether BRCC36 is involved in beta-catenin deubiquitination."