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NLRP3 inhibits BRCC3. 2 / 2

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"A recent paper described E3-ligase SYVN1 as a negative regulator of NLRP3 inflammasome, which causes proteasomal degradation of BRCC3 by attaching Ly48 poly-ubiquitin chains."

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"Another possibility is that because BRCC3 is the sole identified host deubiquitinase of NLRP3, the association of NleA and NLRP3 may impede the access of BRCC3 to the sensor protein."

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IndraLab

Statements

NLRP3 inhibits BRCC3. 2 / 2

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