IndraLab

Statements

BRCC3 binds NLRP3. 19 / 19
5 | 14
reach
"To investigate the expression of BRCC3 and the interaction between NLRP3 and BRCC3 in H/R-induced pyroptosis and cell damage, BRCC3 expression was depleted by the transfection of BRCC3-shRNA into cells prior to induction of hypoxia (Fig. 2A)."
34850961
reach
"Aberrant ubiquitination of NLRP3 in ABRAXAS2-deficient cells appears to limit interactions between NLRP3 and ASC, rather than target NLRP3 for degradation.Biochemical experiments suggest that ABRAXAS2 and BRCC3 associate with NLRP3 after priming."
35608338
reach
"We therefore examined whether NLRP3 phosphorylation regulates the interaction between BRCC3 and NLRP3."
28943315
reach
"The association between ABRAXAS2 and BRCC3 and NLRP3 depends on the phosphorylation of NLRP3 serine 194 and the NLRP3 interactor NIMA-related kinase 7 (NEK7), which acts as a scaffold for bridging adjacent NLRP3 subunits and requires proposed priming [124,125]."
36551253
reach
"BRCC3 binds directly to NLRP3 and promotes the NLRP3 inflammasome activation through its deubiquitination [13]."
37681916
reach
"Co-IP experiments confirmed the interaction between BRCC3 and NLRP3."
34874278
biogrid
No evidence text available
30787184
reach
"18 BRCC3 can directly bind to NLRP3 and favors NLRP3 inflammasome activation through its deubiquitination."
37506136
reach
"Furthermore, NLRP3 needs to be dephosphorylated at S806 to interact with and be deubiquitinated by BRCC3, and interaction of NLRP3 with NEK7 is required for subsequent BRCC3 recruitment and deubiquitylation of NLRP3 (49)."
38022631
reach
"To verify that NLRP3-BRCC3 complex formation is increased by cholesterol accumulation, we pulled down endogenous BRCC3 in acLDL-loaded BMDMs."
38522750
reach
"These findings suggest that increased NLRP3 deubiquitylation mediated through BRCC3/NLRP3 complex formation is a key mechanism underlying NLRP3 inflammasome activation in response to macrophage cholesterol loading.Recently, we showed that JNK was activated due to the decreased Dual-specificity phosphatase 10 (Dusp10) expression in Tet methylcytosine dioxygenase 2 (TET2) deficient macrophages (42)."
38522750
reach
"BRCC3 can directly bind to NLRP3 and favors NLRP3 inflammasome activation through its deubiquitination."
| PMC
biogrid
No evidence text available
31866999
reach
"Another study found that VDR interferes with NLRP3 activation by disrupting deubiquitinase BRCC3-NLRP3 complex to promote NLRP3 degradation in bone marrow-derived macrophage [49]."
38514643
biogrid
No evidence text available
37361896
biogrid
No evidence text available
34615873
biogrid
No evidence text available
32941940
reach
"This work suggested that BRCC3 directly interacted with NLRP3, and its presence was required for appropriate NLRP3 inflammasome formation."
31679183
reach
"VDR can bind to NLRP3 and prevent the process of deubiquitination (NLRP3 activation) mediated by the interaction between NLRP3 and BRCC3 [118]."
37175993