IndraLab

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"We aimed to elucidate the possible role and underlying molecular mechanisms of BRCC36 in VC and revealed that BRCC36 attenuated VC in CKD mice and inhibited the osteogenic differentiation of VSMCs in calcifying medium (CM)."
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"These results indicated that BRCC36 prevents the osteogenic differentiation and calcium deposition of VSMCs."
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"In addition, we found that BRCC36 overexpression upregulated the expression of α-SMA protein, suggesting that BRCC36 attenuated the osteogenic differentiation of rat VSMCs ( Fig. 3 C)."
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"In addition, Cai et al. found that BRCC36 can regulate osteoblastic differentiation of osteoblasts, and the deletion of BRCC36 can promote the activation of alkaline phosphatase and the formation of c[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Inhibition of beta-catenin reversed BRCC3 siRNA induced osteogenic differentiation To test the role of beta-catenin in BRCC3 siRNA actions, cells were treated with XAV939 to inhibit the activation of beta-catenin signaling."
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"In addition, the β-catenin signalling inhibitor XAV939 can reverse the osteogenic differentiation induced by BRCC36 knockdown [ 14 ]."
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"Furthermore, BRCC36 inhibited the osteogenic differentiation of VSMCs in vitro."
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