IndraLab

Statements


BRCC3 activates BRCA1. 6 / 7
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"These results indicate that the two new subunits, BRCC36 and BRE, potentiate the E3 ligase activity of BRCA1 and BARD1."

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"But beside the canonical role of deubiquitinating enzymes in antagonizing ubiquitin ligase activity, BRCC36 also enhances BRCA1 and BARD1 E3 ubiquitin ligase activity."

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"Brcc36 stimulates the catalytic activity of Brca1/Bard1 and cooperates with Brca1/Bard1 in mediating a G2/M-checkpoint arrest."

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"It is tempting to speculate that Brcc36 increases Brca1/Bard1 activity by protecting it from non-productive or even inhibitory autoubiquitination at sites required for substrate binding or E2 binding."

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"The so called BRCA1-A complex comprises RAP80, Abraxas and CCDC98, the deubiquitinase BRCC36, BRCC45 and MERIT40, which are thought to target BRCA1 to IR induced foci through the interaction of RAP80 with polyubiquitin chains such as is thought to occur at histone gamma-H2AX [XREF_BIBR, XREF_BIBR] (see XREF_FIG)."

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"BRCC36 was also shown to promote BRCA1 function in DNA damage response and played an instrumental role in limiting DNA end resection and fine-tuning homologous recombination (HR) repair [19]."