IndraLab

Statements

BRCC3 activates BRCA1. 4 / 5
| 4
reach
"The so called BRCA1-A complex comprises RAP80, Abraxas and CCDC98, the deubiquitinase BRCC36, BRCC45 and MERIT40, which are thought to target BRCA1 to IR induced foci through the interaction of RAP80 with polyubiquitin chains such as is thought to occur at histone gamma-H2AX [XREF_BIBR, XREF_BIBR] (see XREF_FIG)."
24278741
reach
"These results indicate that the two new subunits, BRCC36 and BRE, potentiate the E3 ligase activity of BRCA1 and BARD1."
14636569
reach
"But beside the canonical role of deubiquitinating enzymes in antagonizing ubiquitin ligase activity, BRCC36 also enhances BRCA1 and BARD1 E3 ubiquitin ligase activity."
20817926
reach
"Notably, BRCC36 depletion has been shown to impair activation of BRCA1 and to sensitise breast cancer cells to IR-induced apoptosis [146]."
23712866