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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

Thiolutin inhibits BRCC3. 1 / 1

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"Furthermore, it has recently been demonstrated that the zinc chelating activity of the antibiotic thiolutin inhibits the JAMM metalloprotease activity of the eukaryotic Rpn11 proteasome-complex homologues, the deNEDDylation function of the JAMM metalloproteases Csn5 (of the COP9 signalosome) and also the activities of the eukaryotic BRCC36 enzyme (a deubiquitylase specific to K63 linkages in the BRCA1 and BRCA2 complex) 54."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...