IndraLab

Statements

BRCC3 inhibits NLRP3. 3 / 3
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"Functionally, we show that lentivirus mediated overexpression of WWP2 in murine macrophages inhibits NLRP3 inflammasome activation by decreasing BRCC3 protein level."
33107021
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"Knock-down of BRCC3 with shRNA lentivirus decreased NLRP3 neuronal inflammasome."
31787240
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"BRCC3 knockdown leads to an increase in NLRP3 ubiquitination, and the DUB activity of BRCC3 is required for caspase-1 activation and IL-1beta processing, but not for LPS induced transcription of pro-IL-1beta or of NLRP3 itself XREF_BIBR."
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