IndraLab

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"Here, we showed that most RNF213- and BRCC3 associated miRNAs were elevated in serum of MMD patients, repressed RNF213 and BRCC3 protein expression in HBMVEC, and modulated HBMVEC angiogenesis."

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"Knockdown of this gene resulted in angiogenesis defects, which were also rescued by endothelium specific expression of BRCC3."