IndraLab

Statements

BRCC3 deubiquitinates JNK. 3 / 3
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reach
"Our findings indicate that cholesterol trafficking from the plasma membrane (PM) to the endoplasmic reticulum (ER), via Aster-B leads to the activation of calcium/calmodulin-dependent kinase II (CaMKII) and JNK and subsequent NLRP3 deubiquitylation by BRCC3 to promote NLRP3 inflammasome activation."
38522750
reach
"Cholesterol trafficking from PM to ER, via Aster-B leads to activation of CaMKII/JNK and subsequent NLRP3 deubiquitylation by BRCC3 to promote NLRP3 inflammasome activation."
38522750
reach
"Priming requires IRAK1 activation and proteasome dependent ERK activation (with downstream MEK1/2 activation), and it involves post-translational modifications including : (i) BRCC3 mediated NLRP3 deubiquitination, (ii) LUBAC mediated ASC ubiquitination, and (iii) SYK- and JNK dependent ASC phosphorylation."
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