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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

BRCC3 leads to the deubiquitination of JNK. 1 / 1

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reach

"Priming requires IRAK1 activation and proteasome dependent ERK activation (with downstream MEK1/2 activation), and it involves post-translational modifications including : (i) BRCC3 mediated NLRP3 deubiquitination, (ii) LUBAC mediated ASC ubiquitination, and (iii) SYK- and JNK dependent ASC phosphorylation."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...