IndraLab

Statements

BRCC3 activates tat. 3 / 3
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"Further analysis showed that knockdown of SHMT1,2 or BRCC36 reduced Tat protein stability without affecting mRNA levels (XREF_SUPPLEMENTARY, XREF_SUPPLEMENTARY)."
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"Moreover, point mutation of multiple lysines in Tat, or knockdown of BRCC36 or SHMT1,2, was sufficient to prevent destruction of Tat by JIB-04."
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"Taken together, these data strongly suggest that SHMT2 and BRCC36 and BRISC cooperate to rescue Tat from destruction through removal of K63Ub."
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