IndraLab

"For example, Pellino2 activates NLRP3 through K63-linked ubiquitination during priming, while HUWE1A1 targets NLRP3, NLRC4, and AIM2 with K27-linked polyubiquitination, both boosting inflammasome assembly and pyroptosis.42, 43, 44Deubiquitylation is also crucial in inflammasome activation, with deubiquitinating enzymes (DUBs) like BRCC36 stimulating NLRP3 inflammasome activity and pyroptosis by reversing ubiquitination.45 USPs, a major DUB family regulating NLRP3 inflammasomes, such as USP9X, USP14, USP7, and USP47, promote NLRP3 activity, cytokine release, and pyroptosis through cleaving ubiquitin chains from NLRP3.46, 47, 48 Phosphorylation."

"A posttranscriptional modification, such as NLRP3 deubiquitination mediated by BRCA1/BRCA2-containing complex subunit 3 (BRCC3), is required for NLRP3 activation (signal 2) [67, 68]."

"NLRP3 activation requires a posttranscriptional alteration; NLRP3 deubiquitination mediates by BRCA1/BRCA2-containing complex subunit 3 (BRCC3) (2nd signaling)."