IndraLab

Statements

CD276 increases the amount of BRCC3. 5 / 5
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"In 2016, Sun et al[62] reported in their in vitro study that overexpression of B7-H3 upregulates BRCA1/BRCA2-containing complex subunit 3 (BRCC3) expression and antagonizes the anticancer activity of 5-fluorouracil (5-FU)."
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"Altogether, results suggest that BRCC3 may play a role in B7-H3-induced 5-Fu resistance, such that B7-H3 upregulates BRCC3 expression, enhancing DNA repair in colorectal cancer cells."
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"Moreover, B7-H3 could upregulate BRCC3 or XRCC1 expression to antagonize DNA damage caused by 5-FU or L-OHP in CRC XREF_BIBR, XREF_BIBR."
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"In addition, a few other mechanisms may also underlie B7H3 mediated chemoresistance : (1) B7H3 induces oxaliplatin resistance by increasing the expression of XRCC1 via PI3K and AKT pathway; (2) B7H3 also enhances cell resistance to chemotherapy by increasing the expression of BRCC3, which antagonizes DNA damage caused by 5-FU; (3) or via the activation of the PI3K and AKT pathway."
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"B7-H3 upregulates BRCC3 expression, antagonizing DNA damage caused by 5-Fu."
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