IndraLab

Statements

ABRAXAS2 activates BRCC3. 9 / 11
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reach
"Mechanism by which KIAA0157 supports BRCC36 catalytic function."
26344097
reach
"We pursued crystallization of BRCC36-KIAA0157 subcomplexes from different species (H. sapiens, G. gallus, X. tropicalis, D. rerio, C. floridanus and A. thaliana) to determine the structural basis for (1) how KIAA0157 supports the catalytic function of BRCC36, and (2) how super dimerization of the minimally active BRCC36 and KIAA0157 heterodimer is mediated."
26344097
reach
"To understand how KIAA0157 supports the catalytic function of BRCC36, we set out to solve an inactive-state structure of BRCC36 in isolation."
26344097
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"Abraxas brother 1 (ABRO1), a subunit of the BRCA1/BRCA2-containing complex subunit 36 (BRCC36) isopeptidase complex (BRISC), impedes WW domain-containing E3 ubiquitin-protein ligase 2 (WWP2)-mediated BRCC3 ubiquitination and increases BRCC3 stability [69]."
37047097
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"Interestingly, although CCDC98 functions as an adaptor of BRCC36 and regulates BRCC36 activity in the nucleus, KIAA0157 mainly localizes in cytosol and activates BRCC36 in the cytoplasm."
20656690
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"This likely reflects the fact that the mechanism by which KIAA0157 and Abraxas support BRCC36 will differ from how CSN6 and RPN8 support and regulate the function of CSN5 and RPN11."
26344097
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"BRCC36 is activated in the BRCA1-A complex by the MPN domain protein ABRAXAS and in BRISC particles by the MPN domain protein ABRO1 (Rabl, 2020)."
39600336
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"Many studies have shown that deficiency of ABRO1 substantially reduced the protein levels of the other components of BRISC, especially BRCC3 [23–25]."
37968261
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"Previous structural studies have clearly shown how the BRISC subunit Abro1 binds to and allosterically activates the DUB activity of BRCC36 and how this heterodimer further self-associates to form a " superdimeric " assembly."
28009280