IndraLab

Statements

BRCC3 activates BARD1. 4 / 4
| 4
reach
"But beside the canonical role of deubiquitinating enzymes in antagonizing ubiquitin ligase activity, BRCC36 also enhances BRCA1 and BARD1 E3 ubiquitin ligase activity."
20817926
reach
"Brcc36 stimulates the catalytic activity of Brca1/Bard1 and cooperates with Brca1/Bard1 in mediating a G2/M-checkpoint arrest."
18346885
reach
"It is tempting to speculate that Brcc36 increases Brca1/Bard1 activity by protecting it from non-productive or even inhibitory autoubiquitination at sites required for substrate binding or E2 binding."
18346885
reach
"These results indicate that the two new subunits, BRCC36 and BRE, potentiate the E3 ligase activity of BRCA1 and BARD1."
14636569