IndraLab

Statements

BRCC3 binds BRISC deubiquitase. 2 / 2
| 2
reach
"Although Sagnier et al. [XREF_BIBR] suggested that autophagy selectively degrades HIV-1 Tat through a ubiquitin independent interaction with SQSTM1, Xu et al. demonstrated that HIV-1 Tat undergoes K63 polyubiquitination, a mark recognised by SQSTM1 and the NBR1 autophagy cargo receptor [XREF_BIBR, XREF_BIBR, XREF_BIBR], complexes with the CMA specific chaperone HSPA8 and is subjected to K63Ub selective autophagy mediated by serine hydroxymethyltransferase (SHMT) 1, SHMT2 and the BRCC36 and BRISC deubiquitase complex [XREF_BIBR]."
| PMC
reach
"Here we show that SHMT1,2 and the BRCC36 and BRISC deubiquitase complex are novel and selective regulators of Tat K63, but not K48, ubiquitylation, and its degradation through selective autophagy in T cells."
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