IndraLab
Statements
sparser
"Besides, we found that oeMYSM1 only promoted the mRNA expression of necroptosis-related genes ( Mlkl / Ripk3 ) rather than other PCD-related genes ( Ripk1 / Fas / Zbp1 / Casp3 ) in H/R-induced HL-1 cells ( xref B-G), indicating that MYSM1-STAT1 axis up-regulated the transcription and expression of necroptosis-related genes."
reach
"These data indicated that MYSM1 interacts with STAT1 through the SWIRM domain and deubiquitinates STAT1 through the MPN domain.According to our ubiquitinomics, the K379 residue of STAT1, located in the DNA binding domain (DBD) of STAT1 (Figure 6K), was the most significantly reduced deubiquitination residue of STAT1 after MYSM1 overexpression (Figure 5E)."
reach
"These data indicated that MYSM1 interacts with STAT1 through the SWIRM domain and deubiquitinates STAT1 through the MPN domain.According to our ubiquitinomics, the K379 residue of STAT1, located in the DNA binding domain (DBD) of STAT1 (Figure 6K), was the most significantly reduced deubiquitination residue of STAT1 after MYSM1 overexpression (Figure 5E)."
reach
"In addition to STAT1, we also screen out some potential substrates from our comprehensive proteome-wide quantitative analysis, including Actn4, Aldoa, Isg15, S100a4, Cct7 and Lgals8, which is worthy of further exploration.In conclusion, we showed for the first time that MYSM1 deubiquitinates and stabilizes STAT1 to increase the transcription of necroptosis-related genes in cardiomyocyte under I/R injury."
reach
"In summary, our results demonstrate novel roles for Mysm1 in osteoblast differentiation and osteoclast formation, resulting in osteopenia in Mysm1 deficient mice that could be abrogated by the loss of p53 from increased osteogenic differentiation of Mysm1 -/- p53 -/- MSCs.-Haffner-Luntzer, M., Kovtun, A., Fischer, V., Prystaz, K., Hainzl, A., Kroeger, C. M., Krikki, I., Brinker, T. J., Ignatius, A., Gatzka, M. Loss of p53 compensates osteopenia in murine Mysm1 deficiency."
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"As increased p19 ARF / p53 activation in developing Mysm1 deficient mice could be a consequence of checkpoint activation, a default pathway, or be induced as a result of a lack of 2A-DUB/Mysm1 action in regulatory complexes involved in repression of the Cdkn2a (Ink4 and Arf) locus, we next set out to explore Mysm1 binding to fragments of the p19 ARF promoter in activated thymocytes."
reach
"Mysm1-deficiency is known to result in p53 activation in hematopoietic cells [XREF_BIBR, XREF_BIBR, XREF_BIBR], indicating that MYSM1 normally represses p53 activation, and suggesting it as a possible target for therapeutic p53 activation in hematological malignancies that retain wild type p53 function."
eidos
"Mysm1-deficiency is known to result in p53-activation in hematopoietic cells [ 19,44,45 ] , indicating that MYSM1 normally represses p53 activation , and suggesting it as a possible target for therapeutic p53-activation in hematological malignancies that retain wild type p53 function ."
reach
"Overall, we demonstrate that the loss of MYSM1 in mouse B cell lymphoma represses the induction of ribosomal protein genes, reduces cellular protein synthesis rate, promotes p53 activation and potently inhibits cMYC oncogenic functions.To compare the location of the genomic binding sites of MYSM1 and cMYC, we consolidated the ChIP‐Seq datasets for cMYC and its dimerization partner MAX from multipotent haematopoietic progenitor cells HPC7
12
,
13
with the MYSM1 ChIP‐Seq acquired in our recent work in a B cell progenitor cell line Ba/F3."
MYSM1 affects cell population proliferation
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MYSM1 activates cell population proliferation.
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MYSM1 activates cell population proliferation. 10 / 12
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"On the other hand, our results also demonstrated that MYSM1 accelerates cell proliferation even in the absence of E2, suggesting that MYSM1 may also participate in regulating non-canonic ERα signaling pathway independent on E2 treatment to participate in promoting breast cancer process (Fig. 5A,B)."
reach
"In a separate study, Mysm1 -/- macrophages were confirmed to have elevated production of pro inflammatory cytokines in response to stimulation, as well as increased proliferation, increased apoptosis, and enhanced capacity to control melanoma tumor growth in vivo in mouse models [XREF_BIBR]."
reach
"As a deubiquitinase, MYSM1 stabilizes ERα protein through its MPN enzyme catalytic domain and is recruited with ERα at the promoters of E2-induced genes, thereby triggering transcription initiation and subsequent acceleration in cell proliferation and suppression of antiestrogen sensitivity."
reach
"Above all, the results indicate that MYSM1 promotes cell proliferation and G1-S phase transition in BCa, and the effect of MYSM1 on cell growth is partially related to ERα pathway.To test the functional of MYSM1 on BCa cell growth in vivo, MCF-7 cells infected with shMYSM1 or negative control lentivirus (shCtrl) were individually implanted subcutaneously into flank sides of 4-week-old female BALB/c nude mice (n = 7) armpit."
MYSM1 inhibits cell population proliferation.
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"One of these proteins, Ppp2ca (PP2Ac), functions as a serine/threonine protein phosphatase responsible for a significant portion of eukaryotic protein dephosphorylation events (Fig. xref ). xref The PP2A core enzyme comprises a scaffold subunit (A or PR65 subunit) and a catalytic subunit (C subunit, PP2Ac). xref We observed that PP2Ac interacted with RIPK2, but this interaction was abolished upon IL-1β treatment, and the binding of MYSM1 to RIPK2 was also disrupted under IL-1β stimulation (Fig. xref )."
reach
"Dephosphorylated and deubiquitinated RIPK2 downstream of MYSM1 maintains articular cartilage homeostasis by antagonizing NF-κB and MAPK signaling in OA.As a deubiquitinase, MYSM1 may not directly dephosphorylate RIPK2; instead, it likely recruits other phosphatases during inflammation."
sparser
"Mechanistically, MYSM1 deubiquitinates and dephosphorylates RIPK2 S176 by recruiting PP2A. These findings offer unprecedented evidence of the MYSM1/PP2A/RIPK2 axis’s role in preserving cartilage homeostasis, indicating that targeting MYSM1 and downstream RIPK2 could be therapeutically beneficial for OA treatment."
sparser
"To identify new candidate MYSM1 interaction partners and further investigate the molecular function of MYSM1 in DNA damage responses (DDR), we subsequently performed co-immunoprecipitation (co-IP) experiments in 293T cells transiently overexpressing MYSM1-Flag or GFP-Flag upon treatment with etoposide, followed by an SCX-HPLC MS/MS mass spectrometry proteomics approach [ xref , xref ]."
sparser
"Besides, we found that oeMYSM1 only promoted the mRNA expression of necroptosis-related genes ( Mlkl / Ripk3 ) rather than other PCD-related genes ( Ripk1 / Fas / Zbp1 / Casp3 ) in H/R-induced HL-1 cells ( xref B-G), indicating that MYSM1-STAT1 axis up-regulated the transcription and expression of necroptosis-related genes."
reach
"These data indicated that MYSM1 interacts with STAT1 through the SWIRM domain and deubiquitinates STAT1 through the MPN domain.According to our ubiquitinomics, the K379 residue of STAT1, located in the DNA binding domain (DBD) of STAT1 (Figure 6K), was the most significantly reduced deubiquitination residue of STAT1 after MYSM1 overexpression (Figure 5E)."
reach
"Taken together, these results demonstrated that MYSM1 depletion suppressed the breast cancer cell growth in mice.Given its pleiotropic biological functions, MYSM1 may be a potential therapeutic target for drug development against breast cancer, especially in endocrine resistant ERα-positive breast cancer."
reach
"All this highlights the importance of MYSM1 in mammalian development and hematopoiesis, and the biomedical significance of understanding its functions.Monoubiquitinated histone H2A-K119ub was the first MYSM1 substrate to be discovered, and MYSM1 was shown to promote the expression of androgen receptor target genes in prostate cancer cell lines through H2A-K119ub deubiquitination ."
reach
"27 In prostate cancer cells, Mysm1 activates transcription of androgen receptor regulated genes as part of a co and regulatory complex with histone acetyltransferase p300 and CBP associated factor by coordinating histone acetylation and deubiquitination, and by destabilizing the association of linker histone H1 with nucleosomes."
MYSM1 affects DNA-templated transcription
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MYSM1 activates DNA-templated transcription. 10 / 14
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sparser
"The histone H2A deubiquitinase 2A-DUB or Mysm1/Kiaa1915 (Myb-like SWIRM and MPN domain containing1) is a nuclear protein of 828 amino acids containing a SWIRM domain, a SANT (SWI-SNF, ADA N-CoR, TFIIIB) domain with DNA-binding activity and a JAMN/MPN domain with intrinsic metalloprotease-like activity. xref In prostate cancer cells, Mysm1 activates transcription of androgen receptor-regulated genes as part of a co-regulatory complex with histone acetyltransferase p300/CBP-associated factor by coordinating histone acetylation and deubiquitination, and by destabilizing the association of linker histone H1 with nucleosomes. xref More recently, analysis of Mysm1 knockout mice revealed additional functions of the H2A-DUB in regulation of hematopoietic development as Mysm1 deficiency resulted in – among other abnormalities – severe depletion of B cells and T cells, anemia, and thrombocytosis. xref , xref Comparable with the pathophysiology of mice lacking PRC1 component Bmi1, xref postnatal lymphopenia in Mysm1-deficient mice correlated with a depletion of HSC likely resulting from activation of the DDR and uncontrolled production of reactive oxygen species (ROS). xref In murine skin, Mysm1 deficiency was associated with atrophy (present article and own unpublished observations) and malformation of the tail. xref "
reach
"As a deubiquitinase, MYSM1 stabilizes ERα protein through its MPN enzyme catalytic domain and is recruited with ERα at the promoters of E2-induced genes, thereby triggering transcription initiation and subsequent acceleration in cell proliferation and suppression of antiestrogen sensitivity."
reach
"Additionally, MYSM1 initiates the expression of necroptosis-related genes by promoting the transcription factor function of STAT1.Conclusion: This study illustrated a MYSM1-STAT1 axis in regulating myocardial I/R injury and identified MYSM1 as a pharmacological target for myocardial I/R injury."
MYSM1 affects Cardiotoxicity
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MYSM1 activates Cardiotoxicity.
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MYSM1 inhibits Cardiotoxicity.
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"Overall, this suggested a possible cooperation between cMYC and MYSM1 in the transcriptional regulation of genes encoding ribosomal proteins and translation factors.We have previously validated MYSM1 binding to the promoters of RP genes in Ba/F3 cells by ChIP‐qPCR, and also demonstrated a reduction in RP‐gene expression in Mysm1‐shRNA knockdown Ba/F3 cells and in Mysm1‐deficient primary haematopoietic stem and progenitor cells."
reach
"This firmly establishes that loss of MYSM1 inhibits the oncogenic activity of cMYC, and protects against B cell lymphoma onset and progression in mouse models.To understand the mechanisms underlying the protective activity of MYSM1‐loss in B cell lymphoma, EuMyc tumours were harvested from Mysm1
and control mice, and lymphoma cells isolated by cell‐sorting as live B220 cells, for ex vivo analyses with qRT‐PCR and intracellular flow cytometry."
sparser
"One of these proteins, Ppp2ca (PP2Ac), functions as a serine/threonine protein phosphatase responsible for a significant portion of eukaryotic protein dephosphorylation events (Fig. xref ). xref The PP2A core enzyme comprises a scaffold subunit (A or PR65 subunit) and a catalytic subunit (C subunit, PP2Ac). xref We observed that PP2Ac interacted with RIPK2, but this interaction was abolished upon IL-1β treatment, and the binding of MYSM1 to RIPK2 was also disrupted under IL-1β stimulation (Fig. xref )."
MYSM1 affects ferroptosis
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MYSM1 activates ferroptosis.
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MYSM1 activates ferroptosis. 7 / 7
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"Consequently, we propose that MYSM1 may serve as a more viable therapeutic target than TRIM21 for addressing DOX-induced cardiotoxicity.In conclusion, our results showed that MYSM1 plays a deubiquitination role in regulating TRIM21 stability and mediating DOX-induced cardiomyocyte ferroptosis."
MYSM1 inhibits ferroptosis.
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MYSM1 affects cell differentiation
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MYSM1 inhibits cell differentiation.
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MYSM1 activates cell differentiation.
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MYSM1 activates cell differentiation. 1 / 1
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MYSM1 affects apoptotic process
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MYSM1 inhibits apoptotic process.
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MYSM1 activates apoptotic process.
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MYSM1 affects translation
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MYSM1 activates translation. 8 / 8
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"Given that prior studies have shown that HSCs have a characteristically low level of protein synthesis and we have demonstrated how reduced protein synthesis due to MYSM1 loss can induce ferroptosis, we wondered if overexpression of MYSM1 could augment protein synthesis in healthy HSCs and thereby protect the cells from ferroptosis."
reach
"Recently, Zhao et al. demonstrated that histone deubiquitinase MYSM1 (Myb-like, SWIRM and MPN domains 1) deficiency reduced the translation of ferroptosis-protective mRNAs, resulting in increased ferroptosis of human hematopoietic stem cells (HSCs), and HSC population maintenance was fully restored by the ferroptosis inhibitors (e.g., deferoxamine (DFO), ferrostatin-1 (Fer-1), and vitamin E)16."
reach
"Overall, we demonstrate that the loss of MYSM1 in mouse B cell lymphoma represses the induction of ribosomal protein genes, reduces cellular protein synthesis rate, promotes p53 activation and potently inhibits cMYC oncogenic functions.To compare the location of the genomic binding sites of MYSM1 and cMYC, we consolidated the ChIP‐Seq datasets for cMYC and its dimerization partner MAX from multipotent haematopoietic progenitor cells HPC7
12
,
13
with the MYSM1 ChIP‐Seq acquired in our recent work in a B cell progenitor cell line Ba/F3."
reach
"Similarly, in mouse hematopoietic stem or progenitor cells (HSPCs) MYSM1 was shown to promote the expression of Gfi1, Flt3, Id2, Ebf1 and Pax5 genes, important for the normal progression of hematopoiesis, also via H2A-K119ub deubiquitination of their promoters and other regulatory elements ."
reach
"Moreover, the results showed that MYSM1 depletion inhibited H3K4me3, H3K9ac and H3K27ac levels on ERE regions, suggesting that MYSM1 may crosstalk with the HATs complex to modulate histone modifications on ERE regions of ERα-regulatory genes in BCa-derived cells (Fig. 4D; Appendix Fig. S2A–C)."
reach
"These results suggest that Mysm1 exerts antidepressant effects by affecting ATP levels.Given that energy production in astrocytes is largely dependent on mitochondrial oxidative metabolism in response to neuronal activity,
20
we next tested whether Mysm1 knockdown in astrocytes could produce more ATP."
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"These results suggest that Mysm1 knockdown in astrocytes may upregulate TCA cycle process and mitochondrial oxidative phosphorylation levels to enhance mitochondrial function.Combined with the results that Mysm1 knockdown in astrocytes in vitro could produce more ATP, we explored whether Mysm1 knockdown in vivo could increase ATP in the interstitial space of the brain."
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"These results revealed that Mysm1 accumulation in astrocytes was involved in murine depressive‐like disorders.2.4
Downregulation of Mysm1 Enhanced Mitochondrial Oxidative Phosphorylation and ATP Levels in Astrocytes and Improved Mitochondrial Structure, Alleviating Depression-Like Behaviors in Mice."
reach
"These results revealed that Mysm1 accumulation in astrocytes was involved in murine depressive‐like disorders.2.4
Downregulation of Mysm1 Enhanced Mitochondrial Oxidative Phosphorylation and ATP Levels in Astrocytes and Improved Mitochondrial Structure, Alleviating Depression-Like Behaviors in Mice."
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"For tamoxifen induced Mysm1 gene inactivation in the Mysm1 flox and flox Gt (ROSA) 26Sor tm1 (cre and ERT2) mouse line, the mice were injected intraperitoneally with tamoxifen (T5648, Sigma, St. Louis, MO, USA) in sterilized corn oil (Sigma C8267) at 0.15 mg/g per injection, with eight doses in total administered over 16 days."
reach
"For tamoxifen-induced Mysm1-gene deletion, mice of Mysm1
Cre and control genotypes were injected intraperitoneally with tamoxifen (Sigma-Aldrich, T5648) in sterilized corn oil at 0.12 mg per gram body weight per injection, with 8 doses administered in total over 16 days, as in our previous work ."
Acetylsalicylic acid affects MYSM1
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Acetylsalicylic acid decreases the amount of MYSM1.
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Acetylsalicylic acid inhibits MYSM1.
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Acetylsalicylic acid inhibits MYSM1. 1 / 1
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Acetylsalicylic acid increases the amount of MYSM1.
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Acetylsalicylic acid increases the amount of MYSM1. 1 / 1
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MYSM1 affects Neoplasm Invasiveness
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MYSM1 activates Neoplasm Invasiveness.
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MYSM1 activates Neoplasm Invasiveness. 4 / 4
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"In the present study, we knocked down MYSM1 expression by transfecting siRNA for MYSM1 to CRC SW480 cells and found that MYSM1 silencing inhibited the migration and invasion of CRC cells, indicating that MYSM1 expression was positively associated with cell migration and invasion, which was identical to the clinicopathologic characteristics."
MYSM1 inhibits Neoplasm Invasiveness.
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MYSM1 inhibits Neoplasm Invasiveness. 3 / 3
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"These data exhibited the correlation between MYSM1 and CRC malignancy involving cell metastasis ability but not cell proliferation ability.However, it has been reported that MYSM1 suppressed cellular migration and invasion in renal carcinoma by inhibiting epithelial-mesenchymal transition [XREF_BIBR]."
reach
"Overall, this suggested a possible cooperation between cMYC and MYSM1 in the transcriptional regulation of genes encoding ribosomal proteins and translation factors.We have previously validated MYSM1 binding to the promoters of RP genes in Ba/F3 cells by ChIP‐qPCR, and also demonstrated a reduction in RP‐gene expression in Mysm1‐shRNA knockdown Ba/F3 cells and in Mysm1‐deficient primary haematopoietic stem and progenitor cells."
MYSM1 affects necroptotic process
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MYSM1 activates necroptotic process. 6 / 6
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"Additionally, MYSM1 initiates the expression of necroptosis-related genes by promoting the transcription factor function of STAT1.Conclusion: This study illustrated a MYSM1-STAT1 axis in regulating myocardial I/R injury and identified MYSM1 as a pharmacological target for myocardial I/R injury."
MYSM1 affects cellular senescence
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"In summary, our current results support a role of MYSM1 in DDR: (1) MYSM1 was recruited to DNA lesions induced by etoposide in vitro in human PBMC, KG-1a myeloid leukemia cells, and in melanoma cells. (2) In mass spectrometry analyses, known DNA repair and replication factors, including helicase HELLS and RFC4/5, were identified as novel candidate interaction partners of MYSM1 upon DNA damage induction in 293T cells. (3) The specificity of the interactions of MYSM1 with RFC5, HELLS, and PCNA could be verified by direct and reverse co-IP, and (4) correlated with accumulation of γH2AX in HSPC from aged Mysm1-deficient mice."
reach
"Similarly, in mouse hematopoietic stem or progenitor cells (HSPCs) MYSM1 was shown to promote the expression of Gfi1, Flt3, Id2, Ebf1 and Pax5 genes, important for the normal progression of hematopoiesis, also via H2A-K119ub deubiquitination of their promoters and other regulatory elements ."
sparser
"In summary, our current results support a role of MYSM1 in DDR: (1) MYSM1 was recruited to DNA lesions induced by etoposide in vitro in human PBMC, KG-1a myeloid leukemia cells, and in melanoma cells. (2) In mass spectrometry analyses, known DNA repair and replication factors, including helicase HELLS and RFC4/5, were identified as novel candidate interaction partners of MYSM1 upon DNA damage induction in 293T cells. (3) The specificity of the interactions of MYSM1 with RFC5, HELLS, and PCNA could be verified by direct and reverse co-IP, and (4) correlated with accumulation of γH2AX in HSPC from aged Mysm1-deficient mice."
MYSM1 affects propidium iodide
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MYSM1 increases the amount of propidium iodide.
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MYSM1 activates propidium iodide.
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MYSM1 activates propidium iodide. 1 / 1
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MYSM1 affects innate immune response
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MYSM1 affects aging process
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MYSM1 affects MAPK cascade
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MYSM1 affects DNA Damage
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MYSM1 inhibits DNA Damage.
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MYSM1 activates DNA Damage.
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SWIRM domain affects MYSM1
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MYSM1 affects cGAS-STING
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MYSM1 affects SWIRM domain
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MYSM1 activates MYSM1.
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MYSM1 dephosphorylates MYSM1.
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MYSM1 decreases the amount of MYSM1.
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MYSM1 affects Interferon
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MYSM1 inhibits Interferon.
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MYSM1 activates Interferon.
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reach
"Compared with the full length of MYSM1, the lack of SWIRM domain had little effect on ERα-induced transactivation, while MYSM1-ΔSANT or MYSM1-ΔMPN dramatically reduced ERα action (Fig. 2C), indicating that the SANT or MPN domain is required for the co-activation function of MYSM1 on ERα-mediated transactivation.Indeed, ERα behaves in numerous biological processes through its target genes."
MiR-129-5p affects MYSM1
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PU.1 affects MYSM1
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sparser
"Virtual screening identified Imatinib as a small molecule capable of interacting with the catalytic MPN domain of MYSM1, and this effectively inhibited breast cancer cell growth, highlighting the MYSM1-ERα axis as a promising target to overcome endocrine independence in breast cancer [ xref ]."
| PMC
reach
"Compared with the full length of MYSM1, the lack of SWIRM domain had little effect on ERα-induced transactivation, while MYSM1-ΔSANT or MYSM1-ΔMPN dramatically reduced ERα action (Fig. 2C), indicating that the SANT or MPN domain is required for the co-activation function of MYSM1 on ERα-mediated transactivation.Indeed, ERα behaves in numerous biological processes through its target genes."
MYSM1 affects polyubiquitin chains
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MYSM1 affects miR-200
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MYSM1 affects lifespan
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MYSM1 affects lifespan mice
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MYSM1 affects hemopoiesis
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MYSM1 affects PU.1
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MYSM1 affects MPN domain
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sparser
"These domains belong to the homeobox-like domain superfamily and can be categorized into three groups: the myb-like HTH domain, which binds DNA; the SANT domain, which functions as a protein–protein interaction module; and the myb-like domain, which can participate in either of these functions."
reach
"Similarly, in mouse hematopoietic stem or progenitor cells (HSPCs) MYSM1 was shown to promote the expression of Gfi1, Flt3, Id2, Ebf1 and Pax5 genes, important for the normal progression of hematopoiesis, also via H2A-K119ub deubiquitination of their promoters and other regulatory elements ."
sparser
"Virtual screening identified Imatinib as a small molecule capable of interacting with the catalytic MPN domain of MYSM1, and this effectively inhibited breast cancer cell growth, highlighting the MYSM1-ERα axis as a promising target to overcome endocrine independence in breast cancer [ xref ]."
| PMC
MYSM1 affects Cell Hypoxia
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3
reach
"Above all, the results indicate that MYSM1 promotes cell proliferation and G1-S phase transition in BCa, and the effect of MYSM1 on cell growth is partially related to ERα pathway.To test the functional of MYSM1 on BCa cell growth in vivo, MCF-7 cells infected with shMYSM1 or negative control lentivirus (shCtrl) were individually implanted subcutaneously into flank sides of 4-week-old female BALB/c nude mice (n = 7) armpit."
MPN domain affects MYSM1
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Infections affects MYSM1
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sparser
"These domains belong to the homeobox-like domain superfamily and can be categorized into three groups: the myb-like HTH domain, which binds DNA; the SANT domain, which functions as a protein–protein interaction module; and the myb-like domain, which can participate in either of these functions."
sparser
"Virtual screening identified Imatinib as a small molecule capable of interacting with the catalytic MPN domain of MYSM1, and this effectively inhibited breast cancer cell growth, highlighting the MYSM1-ERα axis as a promising target to overcome endocrine independence in breast cancer [ xref ]."
| PMC
2'-deoxyadenosine affects MYSM1
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Treatments DOX affects MYSM1
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OeMYSM1 affects MYSM1
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Ferrostatin-1 affects MYSM1
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Ferrostatin-1 activates MYSM1. 1 / 1
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reach
"Recently, Zhao et al. demonstrated that histone deubiquitinase MYSM1 (Myb-like, SWIRM and MPN domains 1) deficiency reduced the translation of ferroptosis-protective mRNAs, resulting in increased ferroptosis of human hematopoietic stem cells (HSCs), and HSC population maintenance was fully restored by the ferroptosis inhibitors (e.g., deferoxamine (DFO), ferrostatin-1 (Fer-1), and vitamin E)16."
reach
"Recently, Zhao et al. demonstrated that histone deubiquitinase MYSM1 (Myb-like, SWIRM and MPN domains 1) deficiency reduced the translation of ferroptosis-protective mRNAs, resulting in increased ferroptosis of human hematopoietic stem cells (HSCs), and HSC population maintenance was fully restored by the ferroptosis inhibitors (e.g., deferoxamine (DFO), ferrostatin-1 (Fer-1), and vitamin E)16."
Bentiromide affects MYSM1
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Bentiromide inhibits MYSM1.
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Bentiromide inhibits MYSM1. 1 / 1
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Bentiromide activates MYSM1.
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Bentiromide activates MYSM1. 1 / 1
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TRIM21 affects SWIRM domain
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TRIM21 affects MPN domain
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SWIRM domain affects TRIM21
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SWIRM domain affects STAT1
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STING1 affects K63
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STAT1 affects SWIRM domain
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sparser
"Our transcriptomic analyses, which show no effect of RBM10 downregulation on alternative splicing in GLC20 cells, are supported by (1) our RBM10-only targets ( xref ), which are involved in various aspects of gene expression regulation, excluding alternative splicing, (2) RBM10’s mRNA stabilization effect on its only identified direct RNA target, the AT1 receptor [ xref ], and (3) RBM10’s interaction with the 2A-DUB deubiquitinase protein complex [ xref ] and the Rac-specific GTPase-activitating protein FilGAP [ xref ]."
MYSM1 affects 𝛾 -H2AX
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MYSM1 decreases the amount of 𝛾 -H2AX.
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"However, MYSM1 knockdown did not influence DOX-induced 𝛾 -H2AX expression (Fig. S4C), suggesting that DNA damage might not be one of the pathological conditions in MYSM1-mediated cardiotoxicity.Analogous to the loss-of-function assessment of MYSM1, the gain-of-function of MYSM1 was evaluated by transfecting HL-1 cells with Flag-MYSM1 plasmid (oeMYSM1, Fig. S4D)."
MYSM1 activates 𝛾 -H2AX.
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MYSM1 affects ubH2A
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MYSM1 deubiquitinates ubH2A.
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MYSM1 decreases the amount of ubH2A.
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MYSM1 affects malonaldehyde
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MYSM1 affects histone H2AK119ub
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MYSM1 affects glutathione
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MYSM1 increases the amount of glutathione.
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MYSM1 increases the amount of glutathione. 1 / 1
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MYSM1 decreases the amount of glutathione.
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MYSM1 decreases the amount of glutathione. 1 / 1
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MYSM1 affects gene expression
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MYSM1 affects deoxyribonucleic acid
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MYSM1 affects cellular senescence aging process human mice primary cells mice organs
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MYSM1 affects cell quiescence
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MYSM1 affects Receptors, Pattern Recognition
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sparser
"Our transcriptomic analyses, which show no effect of RBM10 downregulation on alternative splicing in GLC20 cells, are supported by (1) our RBM10-only targets ( xref ), which are involved in various aspects of gene expression regulation, excluding alternative splicing, (2) RBM10’s mRNA stabilization effect on its only identified direct RNA target, the AT1 receptor [ xref ], and (3) RBM10’s interaction with the 2A-DUB deubiquitinase protein complex [ xref ] and the Rac-specific GTPase-activitating protein FilGAP [ xref ]."
sparser
"Virtual screening identified Imatinib as a small molecule capable of interacting with the catalytic MPN domain of MYSM1, and this effectively inhibited breast cancer cell growth, highlighting the MYSM1-ERα axis as a promising target to overcome endocrine independence in breast cancer [ xref ]."
| PMC
MYSM1 affects Osteoarthritis
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MYSM1 inhibits Osteoarthritis.
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MYSM1 inhibits Osteoarthritis. 1 / 1
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MYSM1 binds Osteoarthritis.
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MYSM1 binds Osteoarthritis. 1 / 1
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MYSM1 affects ISRE-Luc
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MYSM1 affects IKK_complex
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MYSM1 increases the amount of IKK_complex.
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MYSM1 increases the amount of IKK_complex. 1 / 1
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MYSM1 decreases the amount of IKK_complex.
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MYSM1 decreases the amount of IKK_complex. 1 / 1
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1
reach
"Similarly, in mouse hematopoietic stem or progenitor cells (HSPCs) MYSM1 was shown to promote the expression of Gfi1, Flt3, Id2, Ebf1 and Pax5 genes, important for the normal progression of hematopoiesis, also via H2A-K119ub deubiquitination of their promoters and other regulatory elements ."
MYSM1 affects Histone_H2A
|
2
MYSM1 deubiquitinates Histone_H2A. 2 / 2
|
2
MYSM1 affects Heart Failure
|
2
reach
"Similarly, in mouse hematopoietic stem or progenitor cells (HSPCs) MYSM1 was shown to promote the expression of Gfi1, Flt3, Id2, Ebf1 and Pax5 genes, important for the normal progression of hematopoiesis, also via H2A-K119ub deubiquitination of their promoters and other regulatory elements ."
sparser
"We recently identified mediator in Arabidopsis thaliana and we have also reported that the Med25 subunit in Arabidopsis interacts with three different transcription factors, Dreb2a, Zfhd1 and myb-like which all are involved in different stress response pathways ( xref , xref ) In this article, we use a set of biochemical and biophysical methods to study interaction between the Med25 mediator subunit and the transcription factor Dreb2a from A. thaliana ."
MYSM1 affects DNA accumulation
|
2
MYSM1 affects DDR-associated SASP
|
2
MYSM1 affects Cell Survival
|
2
sparser
"When we used all 2364 arrays, strong positive correlation between two Myb-like transcription factor genes, Circadian Clock Associated 1 ( CCA1 ) and Late Elongated Hypocotyl ( LHY ) was observed, as well as weak negative correlation between Timing Of Cab expression 1 ( TOC1 ) and LHY , and between TOC1 and CCA1 (Fig. xref A–C and Table xref )."
sparser
"In Arabidopsis, the first-identified clock genes function in a double negative feedback loop, with two morning-phased Myb-like transcription factors, CIRCADIAN CLOCK ASSOCIATED 1 (CCA1) and LATE ELONGATED HYPOCOTYL (LHY), repressing expression of an evening-phased pseudo-response regulator, TIMING OF CAB EXPRESSION 1 (TOC1 or PRR1), which in turn represses expression of CCA1 and LHY ( xref ; xref ; xref ; xref ; xref ; xref ; xref )."
MYSM1 affects ARF
|
1
1
MPN domain affects TRIM21
|
2
K63 affects STING1
|
2
ISD 45 affects MYSM1
|
2
HSV120 affects MYSM1
|
2
sparser
"We recently identified mediator in Arabidopsis thaliana and we have also reported that the Med25 subunit in Arabidopsis interacts with three different transcription factors, Dreb2a, Zfhd1 and myb-like which all are involved in different stress response pathways ( xref , xref ) In this article, we use a set of biochemical and biophysical methods to study interaction between the Med25 mediator subunit and the transcription factor Dreb2a from A. thaliana ."
sparser
"When we used all 2364 arrays, strong positive correlation between two Myb-like transcription factor genes, Circadian Clock Associated 1 ( CCA1 ) and Late Elongated Hypocotyl ( LHY ) was observed, as well as weak negative correlation between Timing Of Cab expression 1 ( TOC1 ) and LHY , and between TOC1 and CCA1 (Fig. xref A–C and Table xref )."
sparser
"In Arabidopsis, the first-identified clock genes function in a double negative feedback loop, with two morning-phased Myb-like transcription factors, CIRCADIAN CLOCK ASSOCIATED 1 (CCA1) and LATE ELONGATED HYPOCOTYL (LHY), repressing expression of an evening-phased pseudo-response regulator, TIMING OF CAB EXPRESSION 1 (TOC1 or PRR1), which in turn represses expression of CCA1 and LHY ( xref ; xref ; xref ; xref ; xref ; xref ; xref )."
Transferase affects MYSM1
|
1
MYSM1 binds transferase. 1 / 1
|
1
Transcription regulator affects MYSM1
|
1
Transcription regulator activates MYSM1. 1 / 1
|
1
Polyubiquitin affects MYSM1
|
1
P53-target gene promoters affects MYSM1
|
1
P16 INK4a mRNA affects MYSM1
|
1
Dorsomorphin affects MYSM1
|
1
Dorsomorphin activates MYSM1. 1 / 1
|
1
C-MET promoter affects MYSM1
|
1
C-MET promoter region affects MYSM1
|
1
Vesicular Stomatitis affects MYSM1
|
1
Vesicular Stomatitis inhibits MYSM1. 1 / 1
|
1
TRF2 affects MYSM1
|
1
TP53 affects ARF
|
1
STING1 affects MPN domain
|
1
STAT1 affects MPN domain.According
|
1
reach
"These data indicated that MYSM1 interacts with STAT1 through the SWIRM domain and deubiquitinates STAT1 through the MPN domain.According to our ubiquitinomics, the K379 residue of STAT1, located in the DNA binding domain (DBD) of STAT1 (Figure 6K), was the most significantly reduced deubiquitination residue of STAT1 after MYSM1 overexpression (Figure 5E)."
Reperfusion Injury affects MYSM1
|
1
Reperfusion Injury activates MYSM1. 1 / 1
|
1
RT-qPCR affects MYSM1
|
1
RPL10 affects MYSM1
|
1
sparser
"In summary, our current results support a role of MYSM1 in DDR: (1) MYSM1 was recruited to DNA lesions induced by etoposide in vitro in human PBMC, KG-1a myeloid leukemia cells, and in melanoma cells. (2) In mass spectrometry analyses, known DNA repair and replication factors, including helicase HELLS and RFC4/5, were identified as novel candidate interaction partners of MYSM1 upon DNA damage induction in 293T cells. (3) The specificity of the interactions of MYSM1 with RFC5, HELLS, and PCNA could be verified by direct and reverse co-IP, and (4) correlated with accumulation of γH2AX in HSPC from aged Mysm1-deficient mice."
Phosphatase affects MYSM1
|
1
MYSM1 binds Phosphatase. 1 / 1
|
1
Petrov JC affects MYSM1
|
1
PROMO database affects MYSM1
|
1
sparser
"Proteins were transferred onto PVDF (polyvinylidene difluoride) membranes in cold buffer (25 m m Tris Base, 192 m m glycine) by electrotransfer for 1.5 h, which were incubated in TBS buffer containing 5% milk for 1 h at 22–24 °C. The membrane was probed at 4 °C overnight with the following primary antibodies: Rabbit anti‐Mysm1 (1:1000, Abcam), rabbit anti‐PGC1 α (1:1000, Cell Signaling Technology), rabbit anti‐p‐p53 (1:1000, Cell Signaling Technology), rabbit anti‐p53 (1:1000, Cell Signaling Technology), rabbit anti‐p‐AMPK (1:1000, Cell Signaling Technology), rabbit anti‐AMPK (1:1000, Cell Signaling Technology), rabbit anti‐Sirt1 (1:1000, Cell Signaling Technology), rabbit anti‐p‐mTOR (1:1000, Cell Signaling Technology), rabbit anti‐mTOR(1:1000, Cell Signaling Technology), rabbit anti‐p‐S6 (1:1000, Cell Signaling Technology), mouse anti‐S6 (1:1000, Cell Signaling Technology), rabbit anti‐GAPDH (1:1000, Abclonal), mouse anti‐ β ‐actin (1:1000, APPLYGEN or Cell Signaling Technology)."
sparser
"In summary, our current results support a role of MYSM1 in DDR: (1) MYSM1 was recruited to DNA lesions induced by etoposide in vitro in human PBMC, KG-1a myeloid leukemia cells, and in melanoma cells. (2) In mass spectrometry analyses, known DNA repair and replication factors, including helicase HELLS and RFC4/5, were identified as novel candidate interaction partners of MYSM1 upon DNA damage induction in 293T cells. (3) The specificity of the interactions of MYSM1 with RFC5, HELLS, and PCNA could be verified by direct and reverse co-IP, and (4) correlated with accumulation of γH2AX in HSPC from aged Mysm1-deficient mice."
Osteoarthritis affects MYSM1
|
1
MYSM1 binds Osteoarthritis. 1 / 1
|
1
Myocardial Ischemia affects MYSM1
|
1
Myocardial Ischemia activates MYSM1. 1 / 1
|
1
MiR-129-5p affects MYSM1
|
1
MYSM1 affects ubiquitination
|
1
MYSM1 affects transferase
|
1
MYSM1 binds transferase. 1 / 1
|
1
MYSM1 affects transcriptional regulator
|
1
MYSM1 increases the amount of transcriptional regulator. 1 / 1
|
1
MYSM1 affects tissue function
|
1
MYSM1 affects senescence cell accumulation mice tissues
|
1
MYSM1 affects response to stress
|
1
MYSM1 inhibits response to stress. 1 / 1
|
1
|
1
MYSM1 affects regulation of cell cycle
|
1
MYSM1 inhibits regulation of cell cycle. 1 / 1
|
1
MYSM1 affects recruitment hematopoietic transcription PU.1
|
1
MYSM1 affects recruitment PRC1 complex proteins RING1B
|
1
MYSM1 affects recruitment E4BP4 Id2 locus
|
1
MYSM1 affects processes senescence
|
1
MYSM1 affects potential primary osteoblasts differentiate mature osteoblasts
|
1
MYSM1 affects polyubiquitin
|
1
MYSM1 affects plasma cell differentiation
|
1
MYSM1 inhibits plasma cell differentiation. 1 / 1
|
1
MYSM1 affects pathways
|
1
MYSM1 affects pathway
|
1
MYSM1 affects pathogenesis
|
1
MYSM1 inhibits pathogenesis. 1 / 1
|
1
MYSM1 affects pathogen recognition receptor
|
1
MYSM1 affects pS2-Pol II
|
1
MYSM1 affects pS176
|
1
MYSM1 affects p53-target gene promoters
|
1
MYSM1 affects p53-activation
|
1
MYSM1 affects p53 pathways
|
1
MYSM1 affects oxidative phosphorylation
|
1
MYSM1 inhibits oxidative phosphorylation. 1 / 1
|
1
reach
"These results suggest that Mysm1 knockdown in astrocytes may upregulate TCA cycle process and mitochondrial oxidative phosphorylation levels to enhance mitochondrial function.Combined with the results that Mysm1 knockdown in astrocytes in vitro could produce more ATP, we explored whether Mysm1 knockdown in vivo could increase ATP in the interstitial space of the brain."
MYSM1 affects organs
|
1
MYSM1 affects neurogenesis
|
1
MYSM1 inhibits neurogenesis. 1 / 1
|
1
MYSM1 affects miR-200 family members
|
1
MYSM1 affects miR-150 transcription
|
1
MYSM1 affects miR-129-5p
|
1
MYSM1 affects inflammatory response
|
1
MYSM1 inhibits inflammatory response. 1 / 1
|
1
MYSM1 affects immune response
|
1
MYSM1 activates immune response. 1 / 1
|
1
MYSM1 affects homeostatic process
|
1
MYSM1 activates homeostatic process. 1 / 1
|
1
reach
"Strong IL-15 receptor stimulation by IL-2 pre-ligated to an anti-IL-2 antibody, or SOCS-3 deficiency, partially restores homeostasis in Id2 deficient NK cells.In support of the role of ID2 in NK cell maturation, deficiency of MYSM1, which mediates the recruitment of E4BP4 to the Id2 locus, leads to defects in NK cell maturation, but not NK lineage specification or commitment (23)."
MYSM1 affects fat cell differentiation
|
1
MYSM1 activates fat cell differentiation. 1 / 1
|
1
|
1
MYSM1 inhibits epithelial to mesenchymal transition. 1 / 1
|
1
MYSM1 affects doxorubicin
|
1
MYSM1 activates doxorubicin. 1 / 1
|
1
MYSM1 affects development aging-associated diseases
|
1
MYSM1 affects defects
|
1
eidos
"Several studies have found that MYSM1 deficiency or mutation can lead to defects during the development and function of HSCs , B cells , natural killer ( NK ) cells and dendritic cells , and it also results in the development of lymphopenia , anemia , and thrombocytopenia , and low B-cell and NK-cell counts in both mice and humans [ 45,51,52,53,54,55 ] ."
MYSM1 affects defects NK cell maturation
|
1
MYSM1 affects decreased bone mass
|
1
MYSM1 activates decreased bone mass. 1 / 1
|
1
MYSM1 affects colony
|
1
MYSM1 affects c-MET promoter
|
1
MYSM1 affects c-MET promoter region
|
1
MYSM1 affects biosynthetic process
|
1
MYSM1 inhibits biosynthetic process. 1 / 1
|
1
MYSM1 affects binding PRC1 complex proteins
|
1
MYSM1 affects aging-related pathologies
|
1
MYSM1 affects aging aging-related pathologies
|
1
MYSM1 affects activation
|
1
MYSM1 affects activation p53 stress response
|
1
MYSM1 affects accumulation aged cells
|
1
MYSM1 affects TRF2
|
1
reach
"Though iron transport, storage, and metabolism as well as antioxidant genes were transcriptionally upregulated or remained unchanged, the levels of key proteins including GPX4, SLC7A11, and FTH1 were all significantly reduced in HSPCs and most profoundly reduced in the primitive HSC-enriched CD34 CD45RA CD90 compartment, which could be rescued by re-expressing WT MYSM1, but not the disease-associated loss-of-function mutants (Figure 6A–B, S6A–B)."
MYSM1 affects TEWL
|
1
MYSM1 affects STAT1.The JAMMs family
|
1
MYSM1 affects Reperfusion Injury
|
1
MYSM1 activates Reperfusion Injury. 1 / 1
|
1
MYSM1 affects RPL10
|
1
sparser
"In summary, our current results support a role of MYSM1 in DDR: (1) MYSM1 was recruited to DNA lesions induced by etoposide in vitro in human PBMC, KG-1a myeloid leukemia cells, and in melanoma cells. (2) In mass spectrometry analyses, known DNA repair and replication factors, including helicase HELLS and RFC4/5, were identified as novel candidate interaction partners of MYSM1 upon DNA damage induction in 293T cells. (3) The specificity of the interactions of MYSM1 with RFC5, HELLS, and PCNA could be verified by direct and reverse co-IP, and (4) correlated with accumulation of γH2AX in HSPC from aged Mysm1-deficient mice."
MYSM1 affects Phosphatase
|
1
MYSM1 binds Phosphatase. 1 / 1
|
1
MYSM1 affects Peritonitis
|
1
MYSM1 activates Peritonitis. 1 / 1
|
1
reach
"Furthermore, Mysm1 -/- plasma cells showed enhanced levels of antibody secretion in vitro and had altered gene expression profiles with downregulation of B cell lineage transcription factors Pax5 and Bach2, and increased expression of plasma cell transcription factors Blimp1 and Xbp1 [XREF_BIBR]."
MYSM1 affects PRC1_complex
|
1
MYSM1 inhibits PRC1_complex. 1 / 1
|
1
sparser
"Proteins were transferred onto PVDF (polyvinylidene difluoride) membranes in cold buffer (25 m m Tris Base, 192 m m glycine) by electrotransfer for 1.5 h, which were incubated in TBS buffer containing 5% milk for 1 h at 22–24 °C. The membrane was probed at 4 °C overnight with the following primary antibodies: Rabbit anti‐Mysm1 (1:1000, Abcam), rabbit anti‐PGC1 α (1:1000, Cell Signaling Technology), rabbit anti‐p‐p53 (1:1000, Cell Signaling Technology), rabbit anti‐p53 (1:1000, Cell Signaling Technology), rabbit anti‐p‐AMPK (1:1000, Cell Signaling Technology), rabbit anti‐AMPK (1:1000, Cell Signaling Technology), rabbit anti‐Sirt1 (1:1000, Cell Signaling Technology), rabbit anti‐p‐mTOR (1:1000, Cell Signaling Technology), rabbit anti‐mTOR(1:1000, Cell Signaling Technology), rabbit anti‐p‐S6 (1:1000, Cell Signaling Technology), mouse anti‐S6 (1:1000, Cell Signaling Technology), rabbit anti‐GAPDH (1:1000, Abclonal), mouse anti‐ β ‐actin (1:1000, APPLYGEN or Cell Signaling Technology)."
sparser
"In summary, our current results support a role of MYSM1 in DDR: (1) MYSM1 was recruited to DNA lesions induced by etoposide in vitro in human PBMC, KG-1a myeloid leukemia cells, and in melanoma cells. (2) In mass spectrometry analyses, known DNA repair and replication factors, including helicase HELLS and RFC4/5, were identified as novel candidate interaction partners of MYSM1 upon DNA damage induction in 293T cells. (3) The specificity of the interactions of MYSM1 with RFC5, HELLS, and PCNA could be verified by direct and reverse co-IP, and (4) correlated with accumulation of γH2AX in HSPC from aged Mysm1-deficient mice."
MYSM1 affects OMIM #618116
|
1
MYSM1 affects Neoplasm Metastasis
|
1
MYSM1 inhibits Neoplasm Metastasis. 1 / 1
|
1
MYSM1 affects NK lineage specification
|
1
MYSM1 affects NF-κB-Luc
|
1
MYSM1 affects Mice Lifespan MYSM1
|
1
MYSM1 affects MiR-129-5p
|
1
MYSM1 affects Mcl-1 mRNA
|
1
MYSM1 affects MPN domain.According
|
1
reach
"These data indicated that MYSM1 interacts with STAT1 through the SWIRM domain and deubiquitinates STAT1 through the MPN domain.According to our ubiquitinomics, the K379 residue of STAT1, located in the DNA binding domain (DBD) of STAT1 (Figure 6K), was the most significantly reduced deubiquitination residue of STAT1 after MYSM1 overexpression (Figure 5E)."
MYSM1 affects Lymphoma, B-Cell
|
1
MYSM1 activates Lymphoma, B-Cell. 1 / 1
|
1
MYSM1 affects LSK
|
1
MYSM1 affects K63-
|
1
MYSM1 affects K48- linked polyubiquitins
|
1
MYSM1 affects IgM
|
1
MYSM1 affects IFN-I
|
1
MYSM1 affects Hypertrophy
|
1
MYSM1 activates Hypertrophy. 1 / 1
|
1
MYSM1 affects Histone_H2B
|
1
MYSM1 binds Histone_H2B. 1 / 1
|
1
MYSM1 affects HATs
|
1
reach
"Moreover, the results showed that MYSM1 depletion inhibited H3K4me3, H3K9ac and H3K27ac levels on ERE regions, suggesting that MYSM1 may crosstalk with the HATs complex to modulate histone modifications on ERE regions of ERα-regulatory genes in BCa-derived cells (Fig. 4D; Appendix Fig. S2A–C)."
MYSM1 affects H3K36M3
|
1
MYSM1 affects H2AK119
|
1
MYSM1 affects Figure 7J-K
|
1
MYSM1 affects Fig.
|
1
MYSM1 affects Ebf1beta promoter
|
1
MYSM1 affects Ebf1alpha promoter
|
1
MYSM1 affects DOX
|
1
MYSM1 affects DNA repair
|
1
MYSM1 activates DNA repair. 1 / 1
|
1
MYSM1 affects DNA damage-induced senescence
|
1
MYSM1 affects DNA Breaks, Double-Stranded
|
1
MYSM1 activates DNA Breaks, Double-Stranded. 1 / 1
|
1
MYSM1 affects DDR-Associated SASP
|
1
MYSM1 affects Cellularity
|
1
MYSM1 affects Cellular Senescence Aging Process Lifespan Abstract Aging
|
1
MYSM1 affects Cardiomyopathies
|
1
MYSM1 inhibits Cardiomyopathies. 1 / 1
|
1
MYSM1 affects Carcinogenesis
|
1
MYSM1 inhibits Carcinogenesis. 1 / 1
|
1
reach
"Though iron transport, storage, and metabolism as well as antioxidant genes were transcriptionally upregulated or remained unchanged, the levels of key proteins including GPX4, SLC7A11, and FTH1 were all significantly reduced in HSPCs and most profoundly reduced in the primitive HSC-enriched CD34 CD45RA CD90 compartment, which could be rescued by re-expressing WT MYSM1, but not the disease-associated loss-of-function mutants (Figure 6A–B, S6A–B)."
MYSM1 affects B1a
|
1
MYSM1 affects Autoimmunity
|
1
MYSM1 inhibits Autoimmunity. 1 / 1
|
1
MYSM1 affects Atrophy
|
1
MYSM1 affects Akt/c-Raf/GSK-3beta
|
1
MYSM1 affects AKT/c-Raf/GSK-3β
|
1
MPN domain.According affects STAT1
|
1
reach
"These data indicated that MYSM1 interacts with STAT1 through the SWIRM domain and deubiquitinates STAT1 through the MPN domain.According to our ubiquitinomics, the K379 residue of STAT1, located in the DNA binding domain (DBD) of STAT1 (Figure 6K), was the most significantly reduced deubiquitination residue of STAT1 after MYSM1 overexpression (Figure 5E)."
MPN domain affects STING1
|
1
K63- affects MYSM1
|
1
K48- linked polyubiquitins affects MYSM1
|
1
Histone_H2B affects MYSM1
|
1
MYSM1 binds Histone_H2B. 1 / 1
|
1
sparser
"In summary, our current results support a role of MYSM1 in DDR: (1) MYSM1 was recruited to DNA lesions induced by etoposide in vitro in human PBMC, KG-1a myeloid leukemia cells, and in melanoma cells. (2) In mass spectrometry analyses, known DNA repair and replication factors, including helicase HELLS and RFC4/5, were identified as novel candidate interaction partners of MYSM1 upon DNA damage induction in 293T cells. (3) The specificity of the interactions of MYSM1 with RFC5, HELLS, and PCNA could be verified by direct and reverse co-IP, and (4) correlated with accumulation of γH2AX in HSPC from aged Mysm1-deficient mice."
HATs affects MYSM1
|
1
E3_Ub_ligase affects MYSM1
|
1
E3_Ub_ligase activates MYSM1. 1 / 1
|
1
DOX affects MYSM1
|
1
DNA90 affects MYSM1
|
1
Adenoviridae Infections affects MYSM1
|
1
Adenoviridae Infections increases the amount of MYSM1. 1 / 1
|
1
ARF affects TP53
|
1
AAV9 affects MYSM1
|
1