IndraLab

Statements

MYSM1 inhibits TP53. 7 / 7
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"These results suggested that the decrease of Mysm1 reduces the threshold of calcium mobilization and makes astrocytes easier to release more ATP.2.5 Mysm1 Knockdown Activated the p53/AMPK Pathway."
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"As previously reported, Mysm1 deficiency could promote p53 pathway activation, thereafter, p53 could activate AMPK, which is involved in regulating the balance of energy metabolism."
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"22 , 23 We set out to verify whether Mysm1 knockdown can activate the p53/AMPK pathway in primary astrocytes and C8‐D1A cells and then to evaluate the ATP level."
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"53 Our work shows that MYSM1 represses p53 stress response genes by antagonizing other histone modifications (H3K27ac and H3K4me3)."
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"As Mysm1 generally functions as a transcription activator, it is rational to postulate that Mysm1 suppresses p53 or p19 ARF likely by activating expression of transcription repressors."
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"Mysm1-deficiency is known to result in p53 activation in hematopoietic cells [XREF_BIBR, XREF_BIBR, XREF_BIBR], indicating that MYSM1 normally represses p53 activation, and suggesting it as a possible target for therapeutic p53 activation in hematological malignancies that retain wild type p53 function."
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"Mysm1-deficiency is known to result in p53-activation in hematopoietic cells [ 19,44,45 ] , indicating that MYSM1 normally represses p53 activation , and suggesting it as a possible target for therapeutic p53-activation in hematological malignancies that retain wild type p53 function ."
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