IndraLab

Statements


BBC3 activates MYSM1. 3 / 3
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"XREF_BIBR, XREF_BIBR PUMA drives MPP cell depletion in Mysm1 deficiency."

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"The downregulation of cell-cycle progression genes, together with the upregulation of p53 effectors in Mysm1 −/− Puma −/− MPPs further supports persistent stress-response activation in these cells."

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"Considering that Mysm1 -/- p53 -/- mice displayed complete rescue of hematopoietic dysfunction, 38 the other p53 effectors identified in our Mysm1 -/- Puma -/- transcriptome analysis may contribute to the PUMA independent but p53 dependent Mysm1 -/- phenotypes."