IndraLab

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MYSM1 activates CD34. 1 / 1

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"Though iron transport, storage, and metabolism as well as antioxidant genes were transcriptionally upregulated or remained unchanged, the levels of key proteins including GPX4, SLC7A11, and FTH1 were all significantly reduced in HSPCs and most profoundly reduced in the primitive HSC-enriched CD34 CD45RA CD90 compartment, which could be rescued by re-expressing WT MYSM1, but not the disease-associated loss-of-function mutants (Figure 6A–B, S6A–B)."

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IndraLab

Statements

MYSM1 activates CD34. 1 / 1

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