IndraLab

Statements

MYSM1 increases the amount of PAX5. 4 / 4
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"MYSM1 was shown to promote expression of Ebf1, Pax5, and Id2, key transcriptional regulators of B-cell commitment and differentiation."
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"Similarly, in mouse hematopoietic stem or progenitor cells (HSPCs) MYSM1 was shown to promote the expression of Gfi1, Flt3, Id2, Ebf1 and Pax5 genes, important for the normal progression of hematopoiesis, also via H2A-K119ub deubiquitination of their promoters and other regulatory elements ."
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"Mechanistic studies revealed that MYSM1 activates Pax5 transcription by coordinating histone modifications and directing the recruitment of the transcription activators such as PU.1 to the Pax5 locus in B cells."
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"Further, we tested the possibility that MYSM1 may directly activate the transcription of Pax5 in mature B cells as well."
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