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MYSM1 deubiquitinates STAT1. 5 / 5
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"MYSM1 deubiquitinates STAT1 and maintains the stability of STAT1."
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"These data indicated that MYSM1 interacts with STAT1 through the SWIRM domain and deubiquitinates STAT1 through the MPN domain.According to our ubiquitinomics, the K379 residue of STAT1, located in the DNA binding domain (DBD) of STAT1 (Figure 6K), was the most significantly reduced deubiquitination residue of STAT1 after MYSM1 overexpression (Figure 5E)."
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"In this study, we demonstrated that MYSM1 deubiquitinates and stabilizes STAT1 through the MPN metalloprotease domain of MYSM1."
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"MYSM1 promotes the Mlkl and Ripk3 expression by deubiquitinating and stabilizing STAT1."
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"In addition to STAT1, we also screen out some potential substrates from our comprehensive proteome-wide quantitative analysis, including Actn4, Aldoa, Isg15, S100a4, Cct7 and Lgals8, which is worthy of further exploration.In conclusion, we showed for the first time that MYSM1 deubiquitinates and stabilizes STAT1 to increase the transcription of necroptosis-related genes in cardiomyocyte under I/R injury."
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