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MYSM1 inhibits ferroptosis. 3 / 3
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"Knockdown of MYSM1 induced an increase in Nrf2 translocation from the cytosol to the nucleus (Fig. 7K), whereas overexpression of MYSM1 reversed this alteration (Fig. 7L), suggesting that MYSM1 may mediate ferroptosis through Nrf2."
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"4 , 6 The recent demonstration that MYSM1 deficiency causes proteostatic stress and ferroptosis in HSCs could explain why SGR provided such a benefit in patient' HSCs."
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"Recent studies have found that the loss of histone deubiquitinase MYSM1 can induce ferroptosis and affect the function of hematopoietic stem cell, providing a new clinical approach for treating complex blood diseases (Zhao et al., 2023)."
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