IndraLab

Statements

MYSM1 activates MYC. 3 / 3
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reach
"This indicates that the loss of MYSM1 can inhibit the oncogenic activity of cMYC and delay the onset of fatal lymphoma.To further establish the protective effect of MYSM1‐loss on lymphoma disease progression, we employed an adoptive lymphoma cell transfer model."
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reach
"This firmly establishes that loss of MYSM1 inhibits the oncogenic activity of cMYC, and protects against B cell lymphoma onset and progression in mouse models.To understand the mechanisms underlying the protective activity of MYSM1‐loss in B cell lymphoma, EuMyc tumours were harvested from Mysm1 and control mice, and lymphoma cells isolated by cell‐sorting as live B220 cells, for ex vivo analyses with qRT‐PCR and intracellular flow cytometry."
34114734
reach
"Loss of MYSM1 inhibits the oncogenic activity of cMYC in B cell lymphoma."
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