IndraLab

Statements

MYSM1 increases the amount of EBF1. 4 / 4
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"Similarly, in mouse hematopoietic stem or progenitor cells (HSPCs) MYSM1 was shown to promote the expression of Gfi1, Flt3, Id2, Ebf1 and Pax5 genes, important for the normal progression of hematopoiesis, also via H2A-K119ub deubiquitination of their promoters and other regulatory elements ."
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"In early B cells, MYSM1 promotes expression of Ebf1, a critical transcriptional regulator of B-cell differentiation."
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"In an attempt to investigate how MYSM1 activates Ebf1 transcription, we first determined whether MYSM1 deubiquitinates ubH2A at the Ebf1 promoter locus of B-cell precursors."
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"MYSM1 was shown to promote expression of Ebf1, Pax5, and Id2, key transcriptional regulators of B-cell commitment and differentiation."
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