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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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MYSM1 increases the amount of TP53. 3 / 3

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"To investigate the underlying mechanisms, we first confirmed that Mysm1 -/- mice had enhanced p53 levels in the Lin - HSCs and LSKs as determined by ICS assays (XREF_FIG)."

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"Nijnik et al. 15 demonstrated that Mysm1 -/- mice have enhanced levels of p53, which is a central regulator of cellular stress responses."

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"Further studies revealed that Mysm1 suppressed p53-target gene Bbc3 and PUMA for HSC maintenance 49 and Mysm1 -/- enhanced p53 levels by upregulation of p19 ARF."

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MYSM1 increases the amount of TP53. 3 / 3

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