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MYSM1 activates ESR. 10 / 10
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"Consistent with these studies, our results indicate that MYSM1 enhances ERα-induced transactivation by eliminating H2Aub deposition."
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"In addition, the results showed that the association between HATs co-regulatory complex and ERα were diminished after MYSM1 knockdown, suggesting that MYSM1 may potentially associate with the HATs complex to up-regulate ERα action (Fig. 4C)."
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"On the other hand, ectopic expression of MYSM1enhanced ERα expression in MCF-7 and HEK293 (Fig. 3D), indicating that MYSM1 up-regulates ERα protein itself at the post-transcriptional level."
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"MYSM1 up-regulated ERα downstream genes, such as c-Myc, VEGF, and CCND1, which play crucial roles in endocrine resistance, suggesting that MYSM1 may act as an ERα co-activator to be involved in conferring endocrine resistance in BCa (Fig. 2)."
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"When cycloheximide (CHX) was applied at specified time points to inhibit protein synthesis, depletion of MYSM1 significantly accelerated ERα degradation and ectopic expression of wild-type MYSM1 plasmid (MYSM1-FL) ameliorated ERα degradation process (Fig. 3C,E)."
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"Taken together, these results demonstrated that MYSM1 depletion suppressed the breast cancer cell growth in mice.Given its pleiotropic biological functions, MYSM1 may be a potential therapeutic target for drug development against breast cancer, especially in endocrine resistant ERα-positive breast cancer."
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"To confirm this result, we further generated transgenic Drosophila with human homolog of CG4751 (MYSM1), the results demonstrated that MYSM1 increased ERα-mediated transactivation, suggesting that MYSM1 may be a co-activator of ERα (Fig. EV1A)."
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"Thus, MYSM1 enhances ERα action via histone and non-histone deubiquitination to promote cell proliferation and antiestrogen insensitivity in breast cancer progression."
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"Meanwhile, MYSM1 knockdown inhibits ERα action in T47D cells, indicating that MYSM1 is a novel co-activator of ERα (Fig. EV2D)."
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"The results showed that MYSM1 simultaneously increased ERα-AF1 and AF2 actions (Figs."
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